(Q37714225)

English

Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance

scientific article published on 26 March 2014

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scholarly article

1 reference

Europe PubMed Central

22 August 2017

Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance (English)

1 reference

Europe PubMed Central

22 August 2017

0 references

object named as

Larisa Yeomans

2

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author name string

Henry I Mosberg

1

1 reference

Europe PubMed Central

22 August 2017

Jessica P Anand

3

1 reference

Europe PubMed Central

22 August 2017

Vanessa Porter

4

1 reference

Europe PubMed Central

22 August 2017

Katarzyna Sobczyk-Kojiro

5

1 reference

Europe PubMed Central

22 August 2017

John R Traynor

6

1 reference

Europe PubMed Central

22 August 2017

Emily M Jutkiewicz

7

1 reference

Europe PubMed Central

22 August 2017

language of work or name

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publication date

26 March 2014

1 reference

Europe PubMed Central

22 August 2017

Journal of Medicinal Chemistry

1 reference

Europe PubMed Central

22 August 2017

57

1 reference

Europe PubMed Central

22 August 2017

7

1 reference

Europe PubMed Central

22 August 2017

3148-3153

1 reference

Europe PubMed Central

22 August 2017

Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid Pharmacophore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Bi- or multifunctional opioid peptide drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Designing multiple ligands - medicinal chemistry strategies and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Cell-penetrating peptides: mechanisms and applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Designed multiple ligands. An emerging drug discovery paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Development of neuropeptide drugs that cross the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

From magic bullets to designed multiple ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 August 2017

Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

6 September 2017

Pentapeptides displaying mu opioid receptor agonist and delta opioid receptor partial agonist/antagonist properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

14 September 2017

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

14 September 2017

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

28 September 2017

Differential binding properties of oripavines at cloned mu- and delta-opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 June 2018

Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

23 June 2018

Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

The ambiguities of opioid tolerance mechanisms: barriers to pain therapeutics or new pain therapeutic possibilities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP[psi].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3993928

1 September 2018

Differential effects of naltrindole on morphine-induced tolerance and physical dependence in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/24641190

12 December 2020

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Identifiers

10.1021/JM5002088

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

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