(Q37739202)

22 August 2017

8 references

19 September 2019

28 November 2019

15 December 2019

22 July 2020

12 September 2020

3 November 2020

31 January 2021

22 August 2022

Mu-conotoxins as leads in the development of new analgesics (English)

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biomedical investigative technique

22 August 2017

main subject

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19 September 2019

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28 November 2019

1 reference

15 December 2019

2 references

22 July 2020

31 January 2021

1 reference

12 September 2020

voltage-gated sodium channel

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3 November 2020

1

Raymond S Norton

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22 August 2017

language of work or name

English

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publication date

19 April 2010

9 references

22 August 2017

19 September 2019

28 November 2019

15 December 2019

22 July 2020

12 September 2020

3 November 2020

31 January 2021

22 August 2022

8 references

22 August 2017

19 September 2019

28 November 2019

15 December 2019

22 July 2020

12 September 2020

3 November 2020

31 January 2021

15

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22 August 2017

issue

4

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22 August 2017

page(s)

2825-2844

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Creative Commons Attribution 3.0 Unported

22 August 2017

copyright license

8 references

19 September 2019

28 November 2019

15 December 2019

22 July 2020

12 September 2020

3 November 2020

31 January 2021

From genes to pain: Na v 1.7 and human pain disorders

22 August 2022

0 references

1 reference

12 December 2020

Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels

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12 December 2020

Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain

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12 December 2020

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

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12 December 2020

Molecular analysis of the sea anemone toxin Av3 reveals selectivity to insects and demonstrates the heterogeneity of receptor site-3 on voltage-gated Na+ channels

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12 December 2020

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels.

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12 December 2020

Incretin-based therapies in type 2 diabetes mellitus

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12 December 2020

Cloning and expression of wild-type and mutant forms of the cardiotonic polypeptide anthopleurin B.

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12 December 2020

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

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12 December 2020

Structural and functional diversities among mu-conotoxins targeting TTX-resistant sodium channels.

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12 December 2020

mu-Conotoxin PIIIA, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes.

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12 December 2020

Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA.

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12 December 2020

Synthesis, biological activity and conformational analysis of cyclic GRF analogs

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12 December 2020

Modulation of vascular calcium channel activity in response to acute volume expansion in rats

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12 December 2020

The M-superfamily of conotoxins: a review

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12 December 2020

Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists

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12 December 2020

Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion

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12 December 2020

Structure, dynamics, and selectivity of the sodium channel blocker mu-conotoxin SIIIA.

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12 December 2020

Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations

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12 December 2020

The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity.

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12 December 2020

Resurgence of sodium channel research

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12 December 2020

Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.

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12 December 2020

Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels

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12 December 2020

Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations.

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12 December 2020

Peptide toxins from venomous Conus snails

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12 December 2020

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation

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12 December 2020

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

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12 December 2020

Solution structure of recombinant somatomedin B domain from vitronectin produced inPichia pastoris

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12 December 2020

Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins.

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12 December 2020

Future potential and status of selective sodium channel blockers for the treatment of pain.

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12 December 2020

High-yield production and characterization of biologically active recombinant aprotinin expressed in Saccharomyces cerevisiae

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12 December 2020

Tertiary structure of conotoxin GIIIA in aqueous solution

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12 December 2020

Sequence-based design of alpha/beta-peptide foldamers that mimic BH3 domains.

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12 December 2020

Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.

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12 December 2020

Consecutive Cyclic Pentapeptide Modules Form Shortα-Helices that are Very Stable to Water and Denaturants

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12 December 2020

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization

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12 December 2020

Direct inhibition of the NOTCH transcription factor complex

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12 December 2020

Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA.

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12 December 2020

A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor

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12 December 2020

Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site

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12 December 2020

Conus geographus toxins that discriminate between neuronal and muscle sodium channels.

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12 December 2020

(alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions

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12 December 2020

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

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12 December 2020

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury.

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12 December 2020

Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels.

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12 December 2020

Therapeutic application of peptides and proteins: parenteral forever?

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12 December 2020

The glatiramoid class of immunomodulator drugs

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12 December 2020

Selecting an appropriate method for expressing a recombinant protein

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12 December 2020

Foldamers with heterogeneous backbones

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12 December 2020

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

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12 December 2020

Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins

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12 December 2020

Conotoxins containing nonnatural backbone spacers: cladistic-based design, chemical synthesis, and improved analgesic activity.

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12 December 2020

Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds

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12 December 2020

Voltage-gated ion channels and gating modifier toxins.

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12 December 2020

The microI skeletal muscle sodium channel: mutation E403Q eliminates sensitivity to tetrodotoxin but not to mu-conotoxins GIIIA and GIIIB.

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12 December 2020

Polyethylene glycol modification of filgrastim results in decreased renal clearance of the protein in rats

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12 December 2020

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

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12 December 2020

Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA

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12 December 2020

Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion

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12 December 2020

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels

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12 December 2020

Lactam bridge stabilization of alpha-helical peptides: ring size, orientation and positional effects

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12 December 2020

Mu-conotoxin SmIIIA, a potent inhibitor of tetrodotoxin-resistant sodium channels in amphibian sympathetic and sensory neurons

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12 December 2020

mu-conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling, and receptor characterization

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12 December 2020

NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA

1 reference

12 December 2020

The roles of sodium channels in nociception: Implications for mechanisms of pain

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12 December 2020

Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels

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12 December 2020

A novel conotoxin from Conus striatus, mu-SIIIA, selectively blocking rat tetrodotoxin-resistant sodium channels

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12 December 2020

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

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12 December 2020

Synthesis and study of peptides with semirigid i and i + 7 side-chain bridges designed for alpha-helix stabilization

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12 December 2020

PEG-modified biopharmaceuticals

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12 December 2020

Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy

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12 December 2020

Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin

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12 December 2020

Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.

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12 December 2020

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

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12 December 2020

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

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12 December 2020

Recent advances in the treatment of acromegaly

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12 December 2020

Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

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12 December 2020

Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

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12 December 2020

Increased peripheral nerve excitability and local NaV1.8 mRNA up-regulation in painful neuropathy.

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12 December 2020

Solution structure of mu-conotoxin GIIIA analysed by 2D-NMR and distance geometry calculations

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12 December 2020

Chimeric study of sodium channels from rat skeletal and cardiac muscle

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12 December 2020

Helices and other secondary structures of beta- and gamma-peptides

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12 December 2020

Sodium channels and nociception: recent concepts and therapeutic opportunities

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12 December 2020

Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels

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12 December 2020

Expression and mutagenesis of the sea anemone toxin Av2 reveals key amino acid residues important for activity on voltage-gated sodium channels.

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12 December 2020

Stabilization of the helical structure of Y2-selective analogues of neuropeptide Y by lactam bridges

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12 December 2020

Identification of high-potency neuropeptide Y analogues through systematic lactamization

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12 December 2020

Forty years of publication of transplantation proceedings--the second decade: the cyclosporine revolution

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12 December 2020

Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue

1 reference

12 December 2020

Somatostatin analog octreotide LAR in gastro-entero-pancreatic tumors

1 reference

12 December 2020

An SCN9A channelopathy causes congenital inability to experience pain

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12 December 2020

Designed peptide analogues of the potassium channel blocker ShK toxin

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12 December 2020

Synthetic therapeutic peptides: science and market

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12 December 2020

Conus venoms: a rich source of novel ion channel-targeted peptides

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12 December 2020

beta-Peptides: from structure to function

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12 December 2020

Development of a bacterial cloning vector for expression of scorpion toxins for biotechnological studies

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12 December 2020

The synthesis and study of side-chain lactam-bridged peptides

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12 December 2020

Peptides as drugs: is there a market?

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12 December 2020

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

1 reference

12 December 2020

Design and synthesis of type-III mimetics of omega-conotoxin GVIA

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12 December 2020

Interactions between a pore-blocking peptide and the voltage sensor of the sodium channel: an electrostatic approach to channel geometry.

1 reference

12 December 2020

Design and synthesis of type-III mimetics of ShK toxin.

1 reference

12 December 2020

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

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12 December 2020

Conotoxins down under

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12 December 2020

Structurally minimized mu-conotoxin analogues as sodium channel blockers: implications for designing conopeptide-based therapeutics

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12 December 2020

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels.

1 reference

12 December 2020

Charge conversion enables quantification of the proximity between a normally-neutral mu-conotoxin (GIIIA) site and the Na+ channel pore

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12 December 2020

Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms

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12 December 2020

Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus

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12 December 2020

Sodium channel toxins--receptor targeting and therapeutic potential

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12 December 2020

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs

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12 December 2020

Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins

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12 December 2020

New reagents, reactions, and peptidomimetics for drug design

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12 December 2020

Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

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12 December 2020

10.3390/MOLECULES15042825

Identifiers

DOI

1 reference

22 August 2017

0 references

1 reference