(Q37750789)

22 August 2017

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title

Targeting telomerase in hematologic malignancy (English)

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22 August 2017

Michelle F Maritz

1

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22 August 2017

Christine E Napier

series ordinal

2

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22 August 2017

Victoria W Wen

series ordinal

3

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22 August 2017

Karen L MacKenzie

series ordinal

4

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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22 August 2017

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22 August 2017

6

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22 August 2017

5

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22 August 2017

769-789

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Extension of life-span by introduction of telomerase into normal human cells

22 August 2017

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

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A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes

21 January 2018

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Telomere fusions caused by mutating the terminal region of telomeric DNA

21 January 2018

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

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Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

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T-loops and the origin of telomeres

21 January 2018

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Telomeres do D-loop-T-loop

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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Telomere length homeostasis

21 January 2018

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Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

21 January 2018

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Origin of Concatemeric T7DNA

21 January 2018

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Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications

21 January 2018

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Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

21 January 2018

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A DNA damage checkpoint response in telomere-initiated senescence

21 January 2018

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The signals and pathways activating cellular senescence

21 January 2018

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Chromosome rearrangements resulting from telomere dysfunction and their role in cancer.

21 January 2018

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In situ analyses of genome instability in breast cancer

21 January 2018

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Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

21 January 2018

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Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

21 January 2018

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Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

21 January 2018

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Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 January 2018

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Telomere terminal transferase activity from Euplotes crassus adds large numbers of TTTTGGGG repeats onto telomeric primers

21 January 2018

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The RNA component of human telomerase

21 January 2018

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Protein composition of catalytically active human telomerase from immortal cells

21 January 2018

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A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

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A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

21 January 2018

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Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

21 January 2018

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Physiological assembly and activity of human telomerase complexes

21 January 2018

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A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis

21 January 2018

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Identification of ATPases pontin and reptin as telomerase components essential for holoenzyme assembly

21 January 2018

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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism

21 January 2018

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Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival

21 January 2018

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Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity

21 January 2018

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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.

21 January 2018

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Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

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Conditional telomerase induction causes proliferation of hair follicle stem cells

21 January 2018

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Telomerase modulates Wnt signalling by association with target gene chromatin

21 January 2018

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Human telomerase reverse transcriptase protects hematopoietic progenitor TF-1 cells from death and quiescence induced by cytokine withdrawal

21 January 2018

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A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis

21 January 2018

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Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

21 January 2018

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Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase

21 January 2018

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Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

21 January 2018

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Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow

21 January 2018

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Human short-term repopulating cells have enhanced telomerase reverse transcriptase expression.

21 January 2018

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Differentiation of immortal cells inhibits telomerase activity.

21 January 2018

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Epigenetic regulation of human telomerase reverse transcriptase promoter activity during cellular differentiation

21 January 2018

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Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity.

21 January 2018

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Telomerase activation by histone deacetylase inhibitor in normal cells

21 January 2018

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Epigenetic control of telomerase and modes of telomere maintenance in aging and abnormal systems

21 January 2018

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Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms

21 January 2018

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hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

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Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.

21 January 2018

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Reconstitution of human telomerase activity in vitro

21 January 2018

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Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells

21 January 2018

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Effects of telomerase modulation in human hematopoietic progenitor cells

21 January 2018

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Bypass of senescence, immortalization, and transformation of human hematopoietic progenitor cells

21 January 2018

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Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts

21 January 2018

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The rate of telomere sequence loss in human leukocytes varies with age.

21 January 2018

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Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals

21 January 2018

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Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.

21 January 2018

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

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Telomere length and replicative aging in human vascular tissues

21 January 2018

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Evidence for a critical telomere length in senescent human fibroblasts

21 January 2018

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The serial cultivation of human diploid cell strains

21 January 2018

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Replicative senescence: implications for in vivo aging and tumor suppression

21 January 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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Karyotypic and phenotypic changes during in vitro aging of human endothelial cells

21 January 2018

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21 January 2018

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Genetic regulation of primitive hematopoietic stem cell senescence

21 January 2018

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Development and aging of primitive hematopoietic stem cells in BALB/cBy mice

21 January 2018

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Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging

21 January 2018

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Long-term erythropoietic repopulating ability of old, young, and fetal stem cells

21 January 2018

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Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure

21 January 2018

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Patterns of occurrence of the leukaemias

21 January 2018

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Establishing the incidence of myelodysplastic syndrome

21 January 2018

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Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells

21 January 2018

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Essential role of mouse telomerase in highly proliferative organs

21 January 2018

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Evidence for a continuous decline in haemopoietic cell function from birth: application to evaluating bone marrow failure in children

21 January 2018

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Telomere Length in Subpopulations of Human Hematopoietic Cells

21 January 2018

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Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size

21 January 2018

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TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.

21 January 2018

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

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Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita

21 January 2018

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Dyskeratosis congenita in all its forms

21 January 2018

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21 January 2018

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X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions

21 January 2018

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Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure

21 January 2018

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Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10

21 January 2018

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Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex

21 January 2018

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Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenita

21 January 2018

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Characterization of primitive hematopoietic cells from patients with dyskeratosis congenita

21 January 2018

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TINF2 mutations result in very short telomeres: analysis of a large cohort of patients with dyskeratosis congenita and related bone marrow failure syndromes

21 January 2018

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TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

21 January 2018

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Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

21 January 2018

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Inhibition of Vertebrate Telomerases by the Triphosphate Derivatives of Some Biologically Active Nucleosides

21 January 2018

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In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families

21 January 2018

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Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants.

21 January 2018

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Telomerase activity and telomere length in pediatric patients with malignancies undergoing chemotherapy.

21 January 2018

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In vivo telomere dynamics of human hematopoietic stem cells

21 January 2018

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Accelerated telomere shortening in hematological lineages is limited to the first year following stem cell transplantation.

21 January 2018

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

21 January 2018

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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

21 January 2018

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Significant telomere shortening in childhood leukemia

21 January 2018

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Telomeric DNA in normal and leukemic blood cells

21 January 2018

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Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations

21 January 2018

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Telomerase activity in normal and malignant hematopoietic cells

21 January 2018

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Telomerase and telomere length in multiple myeloma: correlations with disease heterogeneity, cytogenetic status, and overall survival

21 January 2018

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Critically short telomeres in acute myeloid leukemia with loss or gain of parts of chromosomes

21 January 2018

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Telomere shortening in leukemic cells is related to their genetic alterations but not replicative capability

21 January 2018

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hTERT gene amplification and increased mRNA expression in central nervous system embryonal tumors

21 January 2018

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The human telomerase RNA gene (hTERC) is regulated during carcinogenesis but is not dependent on DNA methylation

21 January 2018

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The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena

21 January 2018

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Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

21 January 2018

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Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence

21 January 2018

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A prospective phase II clinical trial with the use of zidovudine and interferon-alpha in the acute and lymphoma forms of adult T-cell leukemia/lymphoma.

21 January 2018

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Telomere shortening and apoptosis in telomerase-inhibited human tumor cells

21 January 2018

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Creation of human tumour cells with defined genetic elements

21 January 2018

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Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy

21 January 2018

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Telomerase is limiting the growth of acute myeloid leukemia cells.

21 January 2018

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Inhibition of human telomerase activity by peptide nucleic acids.

21 January 2018

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Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

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Telomerase inhibition, oligonucleotides, and clinical trials

21 January 2018

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Inhibition of human telomerase by 2'-O-methyl-RNA

21 January 2018

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Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

21 January 2018

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Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma

21 January 2018

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Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

21 January 2018

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Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer

21 January 2018

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Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo

21 January 2018

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Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase

21 January 2018

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Telomerase and cancer therapeutics

21 January 2018

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Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells.

21 January 2018

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Inhibition of telomerase activity with hTERT antisense increases the effect of CDDP-induced apoptosis in myeloid leukemia

21 January 2018

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Synthetic 2'-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity.

21 January 2018

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Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells

21 January 2018

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Telomerase maintains telomere structure in normal human cells.

21 January 2018

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Efficient RNA interference (RNAi) in Mamallian Cells

21 January 2018

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Telomerase inhibition by stable RNA interference impairs tumor growth and angiogenesis in glioblastoma xenografts.

21 January 2018

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Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

21 January 2018

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Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

21 January 2018

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Rapid inhibition of cancer cell growth induced by lentiviral delivery and expression of mutant-template telomerase RNA and anti-telomerase short-interfering RNA.

21 January 2018

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Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro

21 January 2018

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A highly selective telomerase inhibitor limiting human cancer cell proliferation

21 January 2018

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Screening of telomerase inhibitors

21 January 2018

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Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

21 January 2018

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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.

21 January 2018

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Inhibition of telomerase by G-quartet DNA structures

21 January 2018

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G-quadruplex preferentially forms at the very 3' end of vertebrate telomeric DNA

21 January 2018

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Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay

21 January 2018

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A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity

21 January 2018

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Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

21 January 2018

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Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma

21 January 2018

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Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

21 January 2018

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Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways

21 January 2018

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Frequency of telomerase-specific CD8+ T lymphocytes in patients with cancer.

21 January 2018

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Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy

21 January 2018

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The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

21 January 2018

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Telomerase as a universal tumor-associated antigen for cancer immunotherapy

21 January 2018

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Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

21 January 2018

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Identification of human telomerase reverse transcriptase-derived peptides that induce HLA-A24-restricted antileukemia cytotoxic T lymphocytes

21 January 2018

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Telomerase immunity from bench to bedside: round one.

21 January 2018

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Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients.

21 January 2018

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Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

21 January 2018

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Telomeres and telomerase in hematologic neoplasia

21 January 2018

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Recognition and elongation of telomeres by telomerase

21 January 2018

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Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa

21 January 2018

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Telomerase activity in chronic lymphoproliferative disorders of B-cell lineage

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.10.42

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22 August 2017

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