(Q37763886)

22 August 2017

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title

Neuroinflammation in Huntington's disease (English)

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22 August 2017

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Thomas Möller

1

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22 August 2017

publication date

10 June 2010

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Journal of Neural Transmission

22 August 2017

published in

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22 August 2017

volume

117

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22 August 2017

issue

8

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22 August 2017

page(s)

1001-1008

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Mouse models of Huntington's disease and methodological considerations for therapeutic trials

22 August 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

Expression of the kynurenine pathway enzymes in human microglia and macrophages

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

21 January 2018

12 December 2020

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

Neuroprotective effects of tetracyclines: molecular targets, animal models and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

Early and progressive accumulation of reactive microglia in the Huntington disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

The role of microglial cells in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00702-010-0430-7

HEAT repeats in the Huntington's disease protein

21 January 2018

1 reference

12 December 2020

Microglia and neuroprotection: implications for Alzheimer's disease

1 reference

12 December 2020

Activation and deactivation of gene expression by Ca2+/calcineurin-NFAT-mediated signaling.

1 reference

12 December 2020

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

12 December 2020

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

1 reference

12 December 2020

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12 December 2020

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

1 reference

12 December 2020

The kynurenine pathway of tryptophan degradation as a drug target

1 reference

12 December 2020

Cellular iron status influences the functional relationship between microglia and oligodendrocytes

1 reference

12 December 2020

The inflammatory response in Alzheimer's disease

1 reference

12 December 2020

Microglia biology in health and disease.

1 reference

12 December 2020

Huntington's disease: from pathology and genetics to potential therapies

1 reference

12 December 2020

Pathophysiology of Huntington's disease: from huntingtin functions to potential treatments

1 reference

12 December 2020

Minocycline and neurodegenerative diseases

1 reference

12 December 2020

Construction of human embryonic cDNA libraries: HD, PKD1 and BRCA1 are transcribed widely during embryogenesis

1 reference

12 December 2020

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

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12 December 2020

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

12 December 2020

The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease

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12 December 2020

Neuroinflammation and Parkinson's disease

1 reference

12 December 2020

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

1 reference

12 December 2020

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease

1 reference

12 December 2020

Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases

1 reference

12 December 2020

The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain

1 reference

12 December 2020

Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function.

1 reference

12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

12 December 2020

Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

1 reference

12 December 2020

The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections.

1 reference

12 December 2020

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

1 reference

12 December 2020

Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.

1 reference

12 December 2020

Neurological abnormalities in a knock-in mouse model of Huntington's disease

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12 December 2020

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

1 reference

12 December 2020

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.

1 reference

12 December 2020

Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes, "protective" glial stem cells and stromal ependymal cells

1 reference

12 December 2020

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

1 reference

12 December 2020

Microglial physiology: unique stimuli, specialized responses

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12 December 2020

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

1 reference

12 December 2020

Clinical potential of minocycline for neurodegenerative disorders

1 reference

12 December 2020

Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.

1 reference

12 December 2020

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

1 reference

12 December 2020

Trinucleotide Repeat Disorders

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12 December 2020

Functional role of calcium signals for microglial function.

1 reference

12 December 2020

Distinct neuroinflammatory profile in post-mortem human Huntington's disease.

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12 December 2020

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

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12 December 2020

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

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12 December 2020

Calcium-dependent activation of T-lymphocytes.

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12 December 2020

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

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12 December 2020

Huntingtin-protein interactions and the pathogenesis of Huntington's disease

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12 December 2020

Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease.

1 reference

12 December 2020

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1 reference

12 December 2020

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

1 reference

12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Neuropathological classification of Huntington's disease

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12 December 2020

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12 December 2020

Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models

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12 December 2020

Lack of minocycline efficiency in genetic models of Huntington's disease

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12 December 2020

Translating therapies for Huntington's disease from genetic animal models to clinical trials

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12 December 2020

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

1 reference

12 December 2020

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

1 reference

12 December 2020

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

12 December 2020

Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis

1 reference

12 December 2020

Normal huntingtin function: an alternative approach to Huntington's disease

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12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

The astrocytic GABA(A)/benzodiazepine-like receptor: the Joker receptor for benzodiazepine-mimetic drugs?

1 reference

12 December 2020

Complement 5a controls motility of murine microglial cells in vitro via activation of an inhibitory G-protein and the rearrangement of the actin cytoskeleton

1 reference

12 December 2020

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

12 December 2020

The complement system in regulation of adaptive immunity

1 reference

12 December 2020

Role of complement in neurodegeneration and neuroinflammation.

1 reference

12 December 2020

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

1 reference

12 December 2020

Huntingtin inclusion bodies are iron-dependent centers of oxidative events.

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12 December 2020

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

1 reference

12 December 2020

Calcium signaling in microglial cells

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12 December 2020

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

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12 December 2020

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12 December 2020

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease

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12 December 2020

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

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12 December 2020

Huntington's disease: seeing the pathogenic process through a genetic lens

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12 December 2020

Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites

1 reference

12 December 2020

On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo

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12 December 2020

Endocannabinoid signaling in microglial cells

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12 December 2020

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

1 reference

12 December 2020

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

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12 December 2020

Imaging microglial activation in Huntington's disease

1 reference

12 December 2020

Microglial activation in presymptomatic Huntington's disease gene carriers

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12 December 2020

Inhibitors of histone deacetylases as anti-inflammatory drugs.

1 reference

12 December 2020

Microglia in human immunodeficiency virus-associated neurodegeneration.

1 reference

12 December 2020

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

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12 December 2020

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

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12 December 2020

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

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12 December 2020

Experimental therapeutics in transgenic mouse models of Huntington's disease

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12 December 2020

Positron emission tomography imaging of neuroinflammation

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12 December 2020

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

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12 December 2020

Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage

1 reference

12 December 2020

Microglia in ischemic brain injury

1 reference

12 December 2020

Mechanisms of C5a and C3a complement fragment-induced [Ca2+]i signaling in mouse microglia

1 reference

12 December 2020

Transcriptional signatures in Huntington's disease

1 reference

12 December 2020

Calcium signaling and neurodegenerative diseases

1 reference

12 December 2020

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

1 reference

12 December 2020

10.1007/S00702-010-0430-7

Identifiers

DOI

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22 August 2017

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