(Q37773295)

22 August 2017

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title

Immunodrugs: breaking B- but not T-cell tolerance with therapeutic anticytokine vaccines (English)

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22 August 2017

2

Martin F Bachmann

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22 August 2017

Alexander Link

1

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22 August 2017

1 July 2010

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22 August 2017

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22 August 2017

2

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22 August 2017

4

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22 August 2017

561-574

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Many cytokines are very useful therapeutic targets in disease

22 August 2017

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Challenges in monoclonal antibody-based therapies

21 January 2018

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Therapeutic vaccines against IgE-mediated allergies

21 January 2018

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Virus-like particles: flexible platforms for vaccine development

21 January 2018

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Current developments with peptide-based human tumor vaccines

21 January 2018

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Emerging applications of anticytokine vaccines

21 January 2018

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Therapeutic vaccination for chronic diseases: a new class of drugs in sight

21 January 2018

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The coming of age of virus-like particle vaccines

21 January 2018

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Immunodrugs: therapeutic VLP-based vaccines for chronic diseases

21 January 2018

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Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies

21 January 2018

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Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse model

21 January 2018

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Cellular and genetic mechanisms of self tolerance and autoimmunity

21 January 2018

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Predominant autoantibody production by early human B cell precursors

21 January 2018

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Autoreactivity in human IgG+ memory B cells

21 January 2018

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Human autoantibody silencing by immunoglobulin light chains

21 January 2018

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Impaired early B cell tolerance in patients with rheumatoid arthritis.

21 January 2018

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

21 January 2018

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Silencing of autoreactive B cells by anergy: a fresh perspective.

21 January 2018

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Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.

21 January 2018

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21 January 2018

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The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells

21 January 2018

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Tolerance through indifference: autoreactive B cells to the nuclear antigen La show no evidence of tolerance in a transgenic model.

21 January 2018

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Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells.

21 January 2018

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Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype

21 January 2018

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Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction

21 January 2018

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kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire

21 January 2018

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Igkappa allelic inclusion is a consequence of receptor editing

21 January 2018

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Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis

21 January 2018

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Protection against osteoporosis by active immunization with TRANCE/RANKL displayed on virus-like particles

21 January 2018

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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

21 January 2018

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Virus and virus-like particle-based immunogens for Alzheimer's disease induce antibody responses against amyloid-beta without concomitant T cell responses

21 January 2018

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Induction of autoantibodies to CCR5 in macaques and subsequent effects upon challenge with an R5-tropic simian/human immunodeficiency virus

21 January 2018

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Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles

21 January 2018

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TNFalpha kinoid vaccination-induced neutralizing antibodies to TNFalpha protect mice from autologous TNFalpha-driven chronic and acute inflammation

21 January 2018

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A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis

21 January 2018

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Antigen-specific memory B cell development

21 January 2018

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B-cell tolerance checkpoints in health and autoimmunity

21 January 2018

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Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids

21 January 2018

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Induction of autoimmunity by immunization with hapten-modified hen egg lysozyme in hen egg lysozyme-transgenic mice

21 January 2018

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Determinants of autoantibody induction by conjugated papillomavirus virus-like particles

21 January 2018

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Combined vaccination against IL-5 and eotaxin blocks eosinophilia in mice

21 January 2018

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Antigen epitope-expressing cytokines for DNA immunization.

21 January 2018

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Vaccination with cytokines in autoimmune diseases

21 January 2018

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T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles

21 January 2018

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Virus-like particles as a modular system for novel vaccines

21 January 2018

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Modifications increasing the efficacy of recombinant vaccines; marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine

21 January 2018

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A molecular assembly system that renders antigens of choice highly repetitive for induction of protective B cell responses

21 January 2018

1 reference

A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity

21 January 2018

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On natural and artificial vaccinations

21 January 2018

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A vaccine against nicotine for smoking cessation: a randomized controlled trial

21 January 2018

1 reference

Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study

21 January 2018

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Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults

21 January 2018

1 reference

A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity

21 January 2018

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Novel cytokine peptide-based vaccines: an interleukin-4 vaccine suppresses airway allergic responses in mice.

21 January 2018

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Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice.

21 January 2018

1 reference

Characterization of naturally occurring autoantibodies against tumour necrosis factor-alpha (TNF-alpha): in vitro function and precise epitope mapping by phage epitope library

21 January 2018

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Autoantibodies to tumor necrosis factor in patients with rheumatoid arthritis and systemic lupus erythematosus.

21 January 2018

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Characterization and potential clinical applications of autoantibodies against cytokines

21 January 2018

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Active anti-interferon-alpha immunization: a European-Israeli, randomized, double-blind, placebo-controlled clinical trial in 242 HIV-1--infected patients (the EURIS study).

21 January 2018

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Regulation and pro-inflammatory function of interleukin-17 family cytokines

21 January 2018

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A central role for central tolerance

21 January 2018

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Tolerogenic dendritic cells

21 January 2018

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21 January 2018

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Central tolerance: good but imperfect

21 January 2018

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Peripheral tolerance of CD8 T lymphocytes

21 January 2018

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Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells

21 January 2018

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AIRE in the thymus and beyond

21 January 2018

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Virus-induced autoantibody response to a transgenic viral antigen

21 January 2018

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21 January 2018

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Positive and negative selection of T cells

21 January 2018

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Thymic selection revisited: how essential is it?

21 January 2018

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Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

21 January 2018

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Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

21 January 2018

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How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

21 January 2018

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

21 January 2018

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Complete but curtailed T-cell response to very low-affinity antigen

21 January 2018

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Too dangerous to ignore: self-tolerance and the control of ignorant autoreactive T cells

21 January 2018

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Self antigens expressed by solid tumors Do not efficiently stimulate naive or activated T cells: implications for immunotherapy

21 January 2018

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The molecular signature of CD8+ T cells undergoing deletional tolerance

21 January 2018

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Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance

21 January 2018

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Cancer immunotherapy: moving beyond current vaccines

21 January 2018

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Melanoma vaccines: The problems of local immunosuppression.

21 January 2018

1 reference

The biological functions of T helper 17 cell effector cytokines in inflammation

21 January 2018

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CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.

21 January 2018

1 reference

Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.

21 January 2018

1 reference

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

21 January 2018

1 reference

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.

21 January 2018

1 reference

PD-1 and its ligands in tolerance and immunity

21 January 2018

1 reference

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice.

21 January 2018

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Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

21 January 2018

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Immunology of TLR-independent vaccine adjuvants

21 January 2018

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Identification of adjuvants that enhance the therapeutic antibody response to host IgE.

21 January 2018

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Vaccine adjuvant systems: enhancing the efficacy of sub-unit protein antigens

21 January 2018

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Identification of potent biodegradable adjuvants that efficiently break self-tolerance--a key issue in the development of therapeutic vaccines

21 January 2018

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Vaccine adjuvants alter TCR-based selection thresholds.

21 January 2018

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Advances in saponin-based adjuvants

21 January 2018

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Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis

21 January 2018

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Induction of TNF-alpha autoantibody production by AutoVac TNF106: a novel therapeutic approach for the treatment of allergic diseases

21 January 2018

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Active immunization against murine TNFalpha peptides in mice: generation of endogenous antibodies cross-reacting with the native cytokine and in vivo protection.

21 January 2018

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TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model

21 January 2018

1 reference

Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation

21 January 2018

1 reference

Immunotherapy for Alzheimer's disease

21 January 2018

1 reference

Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses

21 January 2018

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The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

21 January 2018

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Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/IMT.10.30

1 reference

22 August 2017

1 reference

PubMed ID

20636009