(Q37775492)

PubMed publication ID

23 August 2017

1 reference

title

In vitro and ex vivo selection procedures for identifying potentially therapeutic DNA and RNA molecules (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

Francisco J Sánchez-Luque

13 May 2020

author

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

Alfredo Berzal-Herranz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

author name string

Soledad Marton

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

José A Reyes-Darias

2

1 reference

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13 May 2020

Cristina Romero-López

4

1 reference

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13 May 2020

language of work or name

English

0 references

publication date

28 June 2010

1 reference

PubMed publication ID

23 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

page(s)

4610-4638

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

Creative Commons Attribution 4.0 International

13 May 2020

copyright license

start time

28 June 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Aptamers: a new class of oligonucleotides in the drug discovery pipeline?

1 reference

12 December 2020

In vivo properties of an anti-GnRH Spiegelmer: an example of an oligonucleotide-based therapeutic substance class

1 reference

12 December 2020

Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy

1 reference

12 December 2020

Isolation of inhibitory RNA aptamers against severe acute respiratory syndrome (SARS) coronavirus NTPase/Helicase.

1 reference

12 December 2020

The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells

1 reference

12 December 2020

Derivation of RNA aptamer inhibitors of human complement C5.

1 reference

12 December 2020

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

1 reference

12 December 2020

Characterization of 2'-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion.

1 reference

12 December 2020

Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function

1 reference

12 December 2020

In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

1 reference

12 December 2020

Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen

1 reference

12 December 2020

First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity

1 reference

12 December 2020

Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers

1 reference

12 December 2020

In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor.

1 reference

12 December 2020

An allosteric synthetic DNA.

1 reference

12 December 2020

Minimal primer and primer-free SELEX protocols for selection of aptamers from random DNA libraries

1 reference

12 December 2020

A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function

1 reference

12 December 2020

Increased inhibitory ability of conjugated RNA aptamers against the HCV IRES.

1 reference

12 December 2020

Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1

1 reference

12 December 2020

Regulatory pathways governing HIV-1 replication

1 reference

12 December 2020

The human IgE network

1 reference

12 December 2020

Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics

1 reference

12 December 2020

RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1.

1 reference

12 December 2020

In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression

1 reference

12 December 2020

RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.

1 reference

12 December 2020

High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I.

1 reference

12 December 2020

Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer

1 reference

12 December 2020

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

12 December 2020

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1 reference

12 December 2020

A novel strategy for myocardial protection using in vivo transfection of cis element 'decoy' against NFkappaB binding site: evidence for a role of NFkappaB in ischemia-reperfusion injury

1 reference

12 December 2020

In vitro selection of hairpin ribozymes

1 reference

12 December 2020

In vivo evolution of an RNA-based transcriptional activator

1 reference

12 December 2020

Chemical modification of siRNAs for in vivo use.

1 reference

12 December 2020

Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

1 reference

12 December 2020

Inhibitory DNA ligands to platelet-derived growth factor B-chain

1 reference

12 December 2020

Transcription factor decoy for NFkappaB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis

1 reference

12 December 2020

In vitro selection of functional nucleic acids

1 reference

12 December 2020

Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration

1 reference

12 December 2020

In vitro selection identifies key determinants for loop-loop interactions: RNA aptamers selective for the TAR RNA element of HIV-1.

1 reference

12 December 2020

Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells

1 reference

12 December 2020

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

1 reference

12 December 2020

A general purpose RNA-cleaving DNA enzyme

1 reference

12 December 2020

Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX

1 reference

12 December 2020

Protective effects of anti-ricin A-chain RNA aptamer against ricin toxicity

1 reference

12 December 2020

Aptamers: an emerging class of therapeutics

1 reference

12 December 2020

Blocking the initiation of coagulation by RNA aptamers to factor VIIa

1 reference

12 December 2020

Ribozyme catalysis of metabolism in the RNA world

1 reference

12 December 2020

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

1 reference

12 December 2020

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

1 reference

12 December 2020

Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer

1 reference

12 December 2020

1 reference

12 December 2020

Aptamer antagonists of myelin-derived inhibitors promote axon growth

1 reference

12 December 2020

The cluster glycoside effect

1 reference

12 December 2020

Antimetastatic potential of PAI-1-specific RNA aptamers.

1 reference

12 December 2020

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

1 reference

12 December 2020

A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA

1 reference

12 December 2020

DNAzymes as potential therapeutic molecules.

1 reference

12 December 2020

1 reference

12 December 2020

Engineering a ligand-dependent RNA transcriptional activator

1 reference

12 December 2020

Nucleoside, nucleotide and oligonucleotide based amphiphiles: a successful marriage of nucleic acids with lipids

1 reference

12 December 2020

Mirror-image RNA that binds D-adenosine

1 reference

12 December 2020

RNA aptamers targeted to domain II of hepatitis C virus IRES that bind to its apical loop region

1 reference

12 December 2020

H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity.

1 reference

12 December 2020

Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2

1 reference

12 December 2020

Sequence-specific activity of antisense oligonucleotides conjugated to poly (L-lysine) carriers

1 reference

12 December 2020

Distribution and bioactivity of the Ret-specific D4 aptamer in three-dimensional collagen gel cultures.

1 reference

12 December 2020

First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers

1 reference

12 December 2020

A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment

1 reference

12 December 2020

Ribozyme structures and mechanisms

1 reference

12 December 2020

Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102

1 reference

12 December 2020

Delivery of molecular medicine to solid tumors

1 reference

12 December 2020

Inhibition of hepatitis C virus replication and internal ribosome entry site-dependent translation by an RNA molecule

1 reference

12 December 2020

The biology of VEGF and its receptors

1 reference

12 December 2020

A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor

1 reference

12 December 2020

Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2.

1 reference

12 December 2020

von Willebrand factor and the endothelium in vascular disease.

1 reference

12 December 2020

In vitro selection of RNA aptamers against a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1.

1 reference

12 December 2020

In vitro genetic analysis of the Tetrahymena self-splicing intron

1 reference

12 December 2020

Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase

1 reference

12 December 2020

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

1 reference

12 December 2020

In Vitro Incorporation of LNA Nucleotides

1 reference

12 December 2020

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

1 reference

12 December 2020

Transport of molecules in the tumor interstitium: a review

1 reference

12 December 2020

Direct selection for ribozyme cleavage activity in cells

1 reference

12 December 2020

Antiproliferative activity of G-rich oligonucleotides correlates with protein binding

1 reference

12 December 2020

Pilot study of the efficacy of a thrombin inhibitor for use during cardiopulmonary bypass

1 reference

12 December 2020

In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions.

1 reference

12 December 2020

Gaining target access for deoxyribozymes.

1 reference

12 December 2020

Aptazyme-mediated regulation of 16S ribosomal RNA.

1 reference

12 December 2020

Reengineering a natural riboswitch by dual genetic selection

1 reference

12 December 2020

In vitro selection using a dual RNA library that allows primerless selection

1 reference

12 December 2020

A hepatitis C virus (HCV) internal ribosome entry site (IRES) domain III-IV-targeted aptamer inhibits translation by binding to an apical loop of domain IIId

1 reference

12 December 2020

RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells.

1 reference

12 December 2020

In Vitro Selection of Catalytic Polynucleotides

1 reference

12 December 2020

Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library

1 reference

12 December 2020

Protective effects of an aptamer inhibitor of neutrophil elastase in lung inflammatory injury

1 reference

12 December 2020

Selection and characterization of anti-NF-kappaB p65 RNA aptamers

1 reference

12 December 2020

High-affinity IgE receptor on eosinophils is involved in defence against parasites

1 reference

12 December 2020

Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

1 reference

12 December 2020

An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform

1 reference

12 December 2020

Inhibition of VEGF blocks TGF-beta1 production through a PI3K/Akt signalling pathway.

1 reference

12 December 2020

RNA aptamers as reversible antagonists of coagulation factor IXa.

1 reference

12 December 2020

Cell penetrating peptides: overview and applications to the delivery of oligonucleotides

1 reference

12 December 2020

Discovery and development of anticancer aptamers

1 reference

12 December 2020

Aptamer:toxin conjugates that specifically target prostate tumor cells

1 reference

12 December 2020

Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3.

1 reference

12 December 2020

The conformations of locked nucleic acids (LNA)

1 reference

12 December 2020

An efficient RNA aptamer against human influenza B virus hemagglutinin

1 reference

12 December 2020

Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease

1 reference

12 December 2020

Inhibition of hepatitis C virus internal ribosome entry site-mediated translation by an RNA targeting the conserved IIIf domain.

1 reference

12 December 2020

Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.

1 reference

12 December 2020

Bimodal loop-loop interactions increase the affinity of RNA aptamers for HIV-1 RNA structures

1 reference

12 December 2020

In vitro selection of RNA aptamers that bind the RNA-dependent RNA polymerase of hepatitis C virus: a possible role of GC-rich RNA motifs in NS5B binding

1 reference

12 December 2020

Structure-activity of tetrad-forming oligonucleotides as a potent anti-HIV therapeutic drug

1 reference

12 December 2020

A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema

1 reference

12 December 2020

Platelet-derived growth factor (PDGF) and PDGF receptor are induced in mesangial proliferative nephritis in the rat

1 reference

12 December 2020

Isolation and characterization of RNA aptamers specific for the HCV minus-IRES domain I.

1 reference

12 December 2020

Antidote-mediated control of an anticoagulant aptamer in vivo

1 reference

12 December 2020

Endogenous expression of an anti-TAR aptamer reduces HIV-1 replication

1 reference

12 December 2020

Yeast genetic selections to optimize RNA decoys for transcription factor NF-kappa B

1 reference

12 December 2020

RNA aptamers selected against the GluR2 glutamate receptor channel

1 reference

12 December 2020

Interfering with hepatitis C virus IRES activity using RNA molecules identified by a novel in vitro selection method.

1 reference

12 December 2020

The role of neutrophil elastase in chronic inflammation

1 reference

12 December 2020

Apical loop-internal loop interactions: a new RNA-RNA recognition motif identified through in vitro selection against RNA hairpins of the hepatitis C virus mRNA.

1 reference

12 December 2020

Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library

1 reference

12 December 2020

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

12 December 2020

Nuclear factor-kappa B decoy attenuates neuronal damage after global brain ischemia: a future strategy for brain protection during circulatory arrest

1 reference

12 December 2020

Prion-protein-specific aptamer reduces PrPSc formation

1 reference

12 December 2020

Mirror-design of L-oligonucleotide ligands binding to L-arginine

1 reference

12 December 2020

In vitro selection and evolution of RNA: applications for catalytic RNA, molecular recognition, and drug discovery.

1 reference

12 December 2020

Structural and functional studies on platelet-derived growth factor

1 reference

12 December 2020

Tumor targeting by an aptamer

1 reference

12 December 2020

Selection and characterization of an RNA decoy for transcription factor NF-kappa B.

1 reference

12 December 2020

Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

1 reference

12 December 2020

Characterization of anti-NF-kappaB RNA aptamer-binding specificity in vitro and in the yeast three-hybrid system

1 reference

12 December 2020

The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA

1 reference

12 December 2020

Pegaptanib sodium for ocular vascular disease

1 reference

12 December 2020

Inhibition of HIV-1 replication by RNA-based strategies.

1 reference

12 December 2020

In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits

1 reference

12 December 2020

2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

1 reference

12 December 2020

Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase

1 reference

12 December 2020

Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication

1 reference

12 December 2020

An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule

1 reference

12 December 2020

AGRO100 inhibits activation of nuclear factor-kappaB (NF-kappaB) by forming a complex with NF-kappaB essential modulator (NEMO) and nucleolin.

1 reference

12 December 2020

Emerging pharmacologic therapies for wet age-related macular degeneration

1 reference

12 December 2020

In vitro RNA random pools are not structurally diverse: a computational analysis

1 reference

12 December 2020

Minimal RNA aptamer sequences that can inhibit or alleviate noncompetitive inhibition of the muscle-type nicotinic acetylcholine receptor.

1 reference

12 December 2020

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1 reference

12 December 2020

Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity

1 reference

12 December 2020

Mechanism of inhibition of HIV-1 integrase by G-tetrad-forming oligonucleotides in Vitro

1 reference

12 December 2020

Tenascin-C aptamers are generated using tumor cells and purified protein

1 reference

12 December 2020

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.

1 reference

12 December 2020

Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization

1 reference

12 December 2020

The effects of platelet-derived growth factor antagonism in experimental glomerulonephritis are independent of the transforming growth factor-beta system

1 reference

12 December 2020

Structural studies of LNA:RNA duplexes by NMR: conformations and implications for RNase H activity

1 reference

12 December 2020

In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins.

1 reference

12 December 2020

One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors

1 reference

12 December 2020

Therapeutic applications of DNA and RNA aptamers.

1 reference

12 December 2020

RNA pseudoknots that inhibit human immunodeficiency virus type 1 reverse transcriptase

1 reference

12 December 2020

Generation of species cross-reactive aptamers using "toggle" SELEX.

1 reference

12 December 2020

Recent developments in oligonucleotide conjugation

1 reference

12 December 2020

Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801.

1 reference

12 December 2020

Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer

1 reference

12 December 2020

In vitro selection of RNA-based irreversible inhibitors of human neutrophil elastase

1 reference

12 December 2020

Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles

1 reference

12 December 2020

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors

1 reference

12 December 2020

Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

1 reference

12 December 2020

Specific antagonism of PDGF prevents renal scarring in experimental glomerulonephritis

1 reference

12 December 2020

In vitro selection of functional nucleic acid sequences.

1 reference

12 December 2020

Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

1 reference

12 December 2020

Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus

1 reference

12 December 2020

In vitro selection of RNA molecules that bind specific ligands

1 reference

12 December 2020

10.3390/MOLECULES15074610

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6257598&resulttype=core&format=json

13 May 2020

PubMed publication ID

20657381

1 reference