(Q37783350)

23 August 2017

Ion channels as novel therapeutic targets in the treatment of pain (English)

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23 August 2017

1

Alistair Mathie

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23 August 2017

1 September 2010

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Journal of Pharmacy and Pharmacology

23 August 2017

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23 August 2017

62

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23 August 2017

9

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23 August 2017

1089-1095

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Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

23 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The components of membrane conductance in the giant axon of Loligo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Guide to Receptors and Channels (GRAC), 4th Edition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Overview of molecular relationships in the voltage-gated ion channel superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Drugs, their targets and the nature and number of drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Ion channels as drug targets: the next GPCRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

hERG potassium channels and cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

A structural basis for drug-induced long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Trends in ion channel drug discovery: advances in screening technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Ionworks HT: a new high-throughput electrophysiology measurement platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Population patch clamp improves data consistency and success rates in the measurement of ionic currents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

QPatch: the past, present and future of automated patch clamp

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Robotic multiwell planar patch-clamp for native and primary mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

21 January 2018

From molecule to malady

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Inherited neuronal ion channelopathies: new windows on complex neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Episodic ataxia type 1: a neuronal potassium channelopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

M-channels: neurological diseases, neuromodulation, and drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Molecular biology of background K channels: insights from K(2P) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

TREK-1, a K+ channel involved in neuroprotection and general anesthesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

TASK channel deletion in mice causes primary hyperaldosteronism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Crystal structure and mechanism of a calcium-gated potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

X-ray structure of a voltage-dependent K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Subtype-selective targeting of voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The capsaicin receptor: a heat-activated ion channel in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

An SCN9A channelopathy causes congenital inability to experience pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

From genes to pain: Na v 1.7 and human pain disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The neural-glial purinergic receptor ensemble in chronic pain states

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Pain and purinergic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Crystal structure of the ATP-gated P2X(4) ion channel in the closed state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Nociceptors--noxious stimulus detectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Analgesic potential of TRPV1 antagonists

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Clinical development of TRPV1 antagonists: targeting a pivotal point in the pain pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Transient receptor potential channels: targeting pain at the source

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Physiology and pharmacology of two-pore domain potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Molecular background of leak K+ currents: two-pore domain potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Neuronal two-pore-domain potassium channels and their regulation by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The neuronal background K2P channels: focus on TREK1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Emerging roles for two-pore-domain potassium channels and their potential therapeutic impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

TREK-1, a K+ channel involved in polymodal pain perception

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal Cord

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

TREK-2 (K2P10.1) and TRESK (K2P18.1) are major background K+ channels in dorsal root ganglion neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The differential effect of cyclosporine on hypnotic response and pain reaction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The M1P1 loop of TASK3 K2P channels apposes the selectivity filter and influences channel function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Chloride channels as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

The hERG potassium channel as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

Voltage-gated sodium channel blockers for the treatment of chronic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.2042-7158.2010.01131.X

10.1111/J.2042-7158.2010.01131.X

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20796186