(Q37787243)

23 August 2017

title

Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity (English)

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23 August 2017

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1

Fatih M Uckun

1 reference

23 August 2017

Sanjive Qazi

2

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23 August 2017

language of work or name

English

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publication date

10 September 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

published in

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23 August 2017

volume

20

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23 August 2017

issue

11

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23 August 2017

page(s)

1457-1470

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The protein kinase complement of the human genome

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Tyrosine kinases as targets in cancer therapy - successes and failures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Tyrosine kinase inhibitors and the dawn of molecular cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Role of tyrosine kinase inhibitors in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Signaling network of the Btk family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Tyrosine kinases and their substrates in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

TEC-family kinases: regulators of T-helper-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Tec kinases: shaping T-cell activation through actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Immunodeficiency in protein kinase cbeta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Interaction of Bruton's tyrosine kinase and protein kinase Ctheta in platelets. Cross-talk between tyrosine and serine/threonine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Pleckstrin homology domains interact with filamentous actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase is a key regulator in B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

BTK as a mediator of radiation-induced apoptosis in DT-40 lymphoma B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Differential expression and molecular characterisation of Lmo7, Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Tyrosine phosphorylation enhances the SH2 domain-binding activity of Bcr and inhibits Bcr interaction with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Transcription factor STAT5A is a substrate of Bruton's tyrosine kinase in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Recent advances in understanding the cell death pathways activated by anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Targeting apoptosis pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Phospholipase C-gamma 2 couples Bruton's tyrosine kinase to the NF-kappaB signaling pathway in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Constitutive activation of STAT3 and STAT5 is induced by leukemic fusion proteins with protein tyrosine kinase activity and is sufficient for transformation of hematopoietic precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Anti-apoptotic role of STAT5 in haematopoietic cells and in the pathogenesis of malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Interleukin-7 induces apoptosis of 697 pre-B cells expressing dominant-negative forms of STAT5: evidence for caspase-dependent and -independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Chemokine CXCL12 enhances proliferation in pre-B-ALL via STAT5 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

The influence of STAT5 antisense oligonucleotides on the proliferation and apoptosis of selected human leukaemic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Genomic signatures to guide the use of chemotherapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Long-term follow-up of patients who achieved complete remission after donor leukocyte infusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Non-myeloablative allogeneic stem cell transplantation focusing on immunotherapy of life-threatening malignant and non-malignant diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Dual targeting of Bruton's tyrosine kinase and Janus kinase 3 with rationally designed inhibitors prevents graft-versus-host disease (GVHD) in a murine allogeneic bone marrow transplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Platelets and angiogenesis in malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Warfarin versus low-molecular-weight heparin therapy in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Platelet adhesion signalling and the regulation of thrombus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Collagen receptor signalling in platelets: extending the role of the ITAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Genetic analysis of patients with defects in early B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

X linked agammaglobulinaemia and rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. II. Effects of LFM-A13, a specific Btk inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Signaling through CD16b in human neutrophils involves the Tec family of tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Analysis of amphotericin B-induced cell signaling with chemical inhibitors of signaling molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Different roles for non-receptor tyrosine kinases in arachidonate release induced by zymosan and Staphylococcus aureus in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Antisense- and RNA interference-based therapeutic strategies in allergy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Targeted covalent drugs of the kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

Variability in the Degree of Expression of Phosphorylated I B in Chronic Lymphocytic Leukemia Cases With Nodal Involvement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.517750

10.1517/13543776.2010.517750

21 January 2018

Identifiers

DOI

1 reference

release_dngxfcyporhvvp2hq4ebalwhyu

23 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/dngxfcyporhvvp2hq4ebalwhyu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference