(Q37798252)

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TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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Michael W. Chan

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

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Jian-Liang Chou

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Lin-Yu Chen

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Hung-Cheng Lai

3

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Europe PubMed Central

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15 February 2020

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1 November 2010

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Europe PubMed Central

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15 February 2020

Expert Opinion on Therapeutic Targets

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

14

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

11

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1213-1223

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20925461%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Cancer statistics, 2005

1 reference

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21 January 2018

The cell of origin of ovarian epithelial tumors and the ovarian surface epithelium dogma: does the emperor have no clothes?

1 reference

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21 January 2018

Role of endocrine and growth factors on the ovarian surface epithelium.

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21 January 2018

Reproductive factors and risk of ovarian cancer: A prospective study

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21 January 2018

"Incessant ovulation" and ovarian cancer

1 reference

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21 January 2018

Receptors for the TGF-β family

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Ovarian carcinoma cell cultures are resistant to TGF-beta1-mediated growth inhibition despite expression of functional receptors

1 reference

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21 January 2018

Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition

1 reference

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21 January 2018

Transforming growth factor-beta1-dependent urokinase up-regulation and promotion of invasion are involved in Src-MAPK-dependent signaling in human ovarian cancer cells

1 reference

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21 January 2018

The transforming growth factor-beta superfamily of receptors

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

1 reference

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21 January 2018

MADR1, a MAD-related protein that functions in BMP2 signaling pathways

1 reference

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21 January 2018

A human Mad protein acting as a BMP-regulated transcriptional activator

1 reference

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21 January 2018

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

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21 January 2018

The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

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21 January 2018

Specificity and versatility in tgf-beta signaling through Smads

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

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21 January 2018

Smad6 inhibits signalling by the TGF-beta superfamily

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

1 reference

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21 January 2018

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

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21 January 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

1 reference

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21 January 2018

Smad transcription factors

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Early events in the pathogenesis of epithelial ovarian cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

The biology of ovarian cancer: new opportunities for translation

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Aberrant transforming growth factor beta1 signaling and SMAD4 nuclear translocation confer epigenetic repression of ADAM19 in ovarian cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer

1 reference

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21 January 2018

Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

1 reference

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21 January 2018

Worms gang up on bacteria

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21 January 2018

Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions

1 reference

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21 January 2018

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei

1 reference

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21 January 2018

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

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21 January 2018

DNA methylation patterns and epigenetic memory

1 reference

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21 January 2018

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

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21 January 2018

De novo CpG island methylation in human cancer cells

1 reference

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21 January 2018

CpG-rich islands and the function of DNA methylation

1 reference

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21 January 2018

Number of CpG islands and genes in human and mouse

1 reference

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21 January 2018

Genomic imprinting: developmental significance and molecular mechanism

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21 January 2018

CpG island methylator phenotypes in aging and cancer.

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21 January 2018

DNA demethylation in hormone-induced transcriptional derepression

1 reference

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21 January 2018

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

1 reference

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21 January 2018

Epigenetic reprogramming in mammalian development

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21 January 2018

Reactivating the expression of methylation silenced genes in human cancer

1 reference

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21 January 2018

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

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https://api.crossref.org/works/10.1517%2F14728222.2010.525353

21 January 2018

The role of chromatin during transcription

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21 January 2018

Translating the Histone Code

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21 January 2018

Histones and histone modifications

1 reference

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Histone deacetylases and cancer: causes and therapies

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21 January 2018

The Polycomb group protein EZH2 directly controls DNA methylation

1 reference

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21 January 2018

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

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21 January 2018

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

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21 January 2018

Polycomb silencers control cell fate, development and cancer

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21 January 2018

Histone acetyltransferases

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21 January 2018

Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer.

1 reference

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21 January 2018

Histone modifications silence the GATA transcription factor genes in ovarian cancer

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21 January 2018

Epigenetic regulation of ARHI in breast and ovarian cancer cells

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An epigenetic marker panel for screening and prognostic prediction of ovarian cancer.

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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

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21 January 2018

Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis.

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21 January 2018

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

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21 January 2018

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

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21 January 2018

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

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21 January 2018

Promoter hypermethylation profile of ovarian epithelial neoplasms

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21 January 2018

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

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21 January 2018

Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance

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21 January 2018

Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer

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21 January 2018

Epigenetic therapies for chemoresensitization of epithelial ovarian cancer.

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21 January 2018

DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

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21 January 2018

Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer

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Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

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