(Q37805992)

23 August 2017

title

Advances in nucleoside monophosphate prodrugs as anti-HCV agents (English)

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23 August 2017

2

Raymond F Schinazi

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23 August 2017

Drew R Bobeck

1

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23 August 2017

Steven J Coats

series ordinal

3

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23 August 2017

publication date

1 January 2010

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23 August 2017

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23 August 2017

volume

15

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23 August 2017

issue

7

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23 August 2017

page(s)

935-950

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Novel phosphate derivatives of zidovudine as anti-HIV compounds

23 August 2017

cites work

1 reference

12 December 2020

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

1 reference

12 December 2020

Phosphorothioates in molecular biology

1 reference

12 December 2020

Clinical outcomes after transfusion-associated hepatitis C.

1 reference

12 December 2020

Physiological concentrations of purines and pyrimidines

1 reference

12 December 2020

Hepatitis C: the clinical spectrum of disease

1 reference

12 December 2020

Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation

1 reference

12 December 2020

In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate

1 reference

12 December 2020

Natural history of HCV infection

1 reference

12 December 2020

Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial

1 reference

12 December 2020

Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C.

1 reference

12 December 2020

Side effects of therapy of hepatitis C and their management

1 reference

12 December 2020

Mechanisms of antiviral treatment efficacy and failure in chronic hepatitis C.

1 reference

12 December 2020

Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver

1 reference

12 December 2020

Aryloxy phosphoramidate triesters as pro-tides

1 reference

12 December 2020

Control of hepatitis C: a medicinal chemistry perspective

1 reference

12 December 2020

Synthesis of 9-(2-beta-C-methyl-beta-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication.

1 reference

12 December 2020

Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.

1 reference

12 December 2020

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay

1 reference

12 December 2020

Challenges and successes in developing new therapies for hepatitis C.

1 reference

12 December 2020

Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy

1 reference

12 December 2020

Chronic hepatitis C virus management: 2000-2005 update

1 reference

12 December 2020

HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.

1 reference

12 December 2020

Hepatitis C: a review for primary care physicians

1 reference

12 December 2020

Recent development of therapeutics for chronic HCV infection

1 reference

12 December 2020

Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine.

1 reference

12 December 2020

Mechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase

1 reference

12 December 2020

Prodrug approaches of nucleotides and oligonucleotides

1 reference

12 December 2020

6-Hydrazinopurine 2'-methyl ribonucleosides and their 5'-monophosphate prodrugs as potent hepatitis C virus inhibitors

1 reference

12 December 2020

Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication

1 reference

12 December 2020

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

1 reference

12 December 2020

Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

1 reference

12 December 2020

Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection

1 reference

12 December 2020

Prodrugs of nucleoside analogues for improved oral absorption and tissue targeting

1 reference

12 December 2020

2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication

1 reference

12 December 2020

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus

1 reference

12 December 2020

The way forward in HCV treatment--finding the right path

1 reference

12 December 2020

Prodrugs of phosphates and phosphonates

1 reference

12 December 2020

The Hepatitis C Virus Replicon Presents a Higher Barrier to Resistance to Nucleoside Analogs than to Nonnucleoside Polymerase or Protease Inhibitors

1 reference

12 December 2020

High-throughput synthesis of HepDirect prodrugs of nucleoside monophosphates

1 reference

12 December 2020

Approaches for the development of antiviral compounds: the case of hepatitis C virus

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12 December 2020

Synthesis and evaluation of novel phosphoramidate prodrugs of 2'-methyl cytidine as inhibitors of hepatitis C virus NS5B polymerase

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12 December 2020

The Octadecyloxyethyl Ester of (S)-9-[3-Hydroxy-2-(Phosphonomethoxy) Propyl]Adenine Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication in Genotype 1A, 1B, and 2A Replicons

1 reference

12 December 2020

Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo

1 reference

12 December 2020

Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine

1 reference

12 December 2020

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

1 reference

12 December 2020

HCV NS5B polymerase inhibitors

1 reference

12 December 2020

Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection

1 reference

12 December 2020

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs

1 reference

12 December 2020

HCV drug discovery aimed at viral eradication

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12 December 2020

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

1 reference

12 December 2020

Identifiers

DOI

10.3851/IMP1667

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23 August 2017

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