(Q37806625)

23 August 2017

Triggers for genomic rearrangements: insights into genomic, cellular and environmental influences (English)

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23 August 2017

Ram-Shankar Mani

1

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PubMed ID

21045868

23 August 2017

Arul M Chinnaiyan

series ordinal

2

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23 August 2017

3 November 2010

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23 August 2017

Nature Reviews Genetics

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23 August 2017

11

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23 August 2017

819-829

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23 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrg2883

23 August 2017

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PML/RAR alpha fusion gene is expressed in both granuloid/macrophage and erythroid colonies in acute promyelocytic leukaemia

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PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

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Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements

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Active genes dynamically colocalize to shared sites of ongoing transcription

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Continued expression of a tissue specific activated oncogene in the early steps of radiation-induced human thyroid carcinogenesis

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31 March 2020

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DNA breaks at fragile sites generate oncogenic RET/PTC rearrangements in human thyroid cells

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Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

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Oxidants are a major contributor to aging

31 March 2020

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ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage

31 March 2020

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Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants

31 March 2020

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A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage

31 March 2020

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Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death

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The connection between transcription and genomic instability

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

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Rare pathogenic microdeletions and tandem duplications are microhomology-mediated and stimulated by local genomic architecture

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ATR Regulates Fragile Site Stability

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ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

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Mechanisms of change in gene copy number

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The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans

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A microhomology-mediated break-induced replication model for the origin of human copy number variation

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A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders

31 March 2020

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A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

31 March 2020

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Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

31 March 2020

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

31 March 2020

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Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

31 March 2020

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Loss of drug-stimulated topoisomerase II DNA breaks in living cells is different at two unrelated loci

31 March 2020

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Chromatin structural elements and chromosomal translocations in leukemia

31 March 2020

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Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma

31 March 2020

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

31 March 2020

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Frequent chromosomal translocations induced by DNA double-strand breaks

31 March 2020

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Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation

31 March 2020

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Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

31 March 2020

1 reference

IgH class switching and translocations use a robust non-classical end-joining pathway

31 March 2020

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Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

31 March 2020

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NHEJ and its backup pathways in chromosomal translocations

31 March 2020

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

31 March 2020

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Genome destabilization by homologous recombination in the germ line

31 March 2020

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Genome architecture, rearrangements and genomic disorders

31 March 2020

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The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

31 March 2020

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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

31 March 2020

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31 March 2020

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Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

31 March 2020

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AID is required for c-myc/IgH chromosome translocations in vivo

31 March 2020

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Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

31 March 2020

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AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

31 March 2020

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AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations

31 March 2020

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Two levels of protection for the B cell genome during somatic hypermutation.

31 March 2020

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31 March 2020

Chromosome fragile sites

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Common fragile sites as targets for chromosome rearrangements

31 March 2020

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Non-B DNA conformations, mutagenesis and disease

31 March 2020

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DNA structures at chromosomal translocation sites

31 March 2020

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DNA structure-induced genomic instability in vivo

31 March 2020

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Z-DNA-forming sequences generate large-scale deletions in mammalian cells

31 March 2020

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Unexpectedly high rate of de novo constitutional t(11;22) translocations in sperm from normal males

31 March 2020

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Genetic variation affects de novo translocation frequency.

31 March 2020

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A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

31 March 2020

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Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity

31 March 2020

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Natural mutagenesis of human genomes by endogenous retrotransposons

31 March 2020

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Mobile interspersed repeats are major structural variants in the human genome

31 March 2020

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LINE-1 retrotransposition activity in human genomes

31 March 2020

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High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes

31 March 2020

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MLL: a histone methyltransferase disrupted in leukemia

31 March 2020

1 reference

A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element.

31 March 2020

1 reference

A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

31 March 2020

1 reference

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

31 March 2020

1 reference

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations

31 March 2020

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Genetics. Genetic control of hotspots.

31 March 2020

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PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

31 March 2020

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Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation

31 March 2020

1 reference

Paired-end mapping reveals extensive structural variation in the human genome

31 March 2020

1 reference

The 1000 Genomes Project: new opportunities for research and social challenges

31 March 2020

1 reference

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

31 March 2020

1 reference

Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia.

31 March 2020

1 reference

12 December 2020

High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident

1 reference

12 December 2020

The nuclear topography of ABL, BCR, PML, and RARalpha genes: evidence for gene proximity in specific phases of the cell cycle and stages of hematopoietic differentiation

1 reference

12 December 2020

In vitro irradiation is able to cause RET oncogene rearrangement

1 reference

12 December 2020

Selective induction of leukemia-associated fusion genes by high-dose ionizing radiation

1 reference

12 December 2020

New approaches to lymphoma diagnosis

1 reference

12 December 2020

Chromosome studies on normal and leukemic human leukocytes

1 reference

12 December 2020

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma

1 reference

12 December 2020

1 reference

12 December 2020

Chromosome studies in human leukemia. II. Chronic granulocytic leukemia

1 reference

12 December 2020

Distribution of ABL and BCR genes in cell nuclei of normal and irradiated lymphocytes

1 reference

12 December 2020

Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident

1 reference

12 December 2020

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG2883

1 reference

23 August 2017

1 reference

PubMed ID

21045868