(Q37809745)

23 August 2017

The role of Aire in clonal selection (English)

1 reference

23 August 2017

Ruth T Taniguchi

1

1 reference

23 August 2017

Mark S Anderson

series ordinal

2

1 reference

23 August 2017

16 November 2010

1 reference

Immunology & Cell Biology

23 August 2017

1 reference

23 August 2017

89

1 reference

23 August 2017

1

1 reference

23 August 2017

40-44

1 reference

https://scigraph.springernature.com/pub.10.1038/icb.2010.132

23 August 2017

0 references

cites work

Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Aire's partners in the molecular control of immunological tolerance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Transcriptional impact of Aire varies with cell type

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Deletional tolerance mediated by extrathymic Aire-expressing cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Chromosomal clustering of genes controlled by the aire transcription factor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Visualizing dendritic cell networks in vivo

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Aire regulates negative selection of organ-specific T cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Positive and negative selection of T cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Projection of an immunological self shadow within the thymus by the aire protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Positional cloning of the APECED gene

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

The V(D)J recombination activating gene, RAG-1.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Autoimmune polyendocrinopathy--candidiasis--ectodermal dystrophy (APECED).

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Role of the thymus and related organs in immunity.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

The cellular mechanism of Aire control of T cell tolerance.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

T cell tolerance by clonal elimination in the thymus

1 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

IMMUNOLOGICAL FUNCTION OF THE THYMUS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3017232

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

3 December 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21079643

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21079643

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.132

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ICB.2010.132

1 reference

Dimensions Publication ID

23 August 2017

0 references

1 reference

23 August 2017

PubMed publication ID

21079643

1 reference