(Q37810190)

23 August 2017

title

Bioanalysis of siRNA and oligonucleotide therapeutics in biological fluids and tissues (English)

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23 August 2017

Guy A Tremblay

1

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23 August 2017

Philip R Oldfield

series ordinal

2

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23 August 2017

language of work or name

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1 June 2009

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23 August 2017

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23 August 2017

volume

1

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23 August 2017

issue

3

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23 August 2017

page(s)

595-609

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RNA interference and chemically modified small interfering RNAs

23 August 2017

cites work

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Origins and Mechanisms of miRNAs and siRNAs

21 January 2018

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The promises and pitfalls of RNA-interference-based therapeutics

21 January 2018

1 reference

Antisense technology: a selective tool for gene expression regulation and gene targeting

21 January 2018

1 reference

Therapeutic applications of aptamers

21 January 2018

1 reference

Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

1 reference

MicroRNA silencing in primates: towards development of novel therapeutics

21 January 2018

1 reference

Treatment of allergic asthma by targeting transcription factors using nucleic-acid based technologies

21 January 2018

1 reference

Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies.

21 January 2018

1 reference

Patents on SELEX and therapeutic aptamers

21 January 2018

1 reference

Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.

21 January 2018

1 reference

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

21 January 2018

1 reference

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

1 reference

Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone

21 January 2018

1 reference

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

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Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo

21 January 2018

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Aptamer therapeutics advance

21 January 2018

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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs.

21 January 2018

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Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

21 January 2018

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Cellular proteins prevent antisense phosphorothioate oligonucleotide (SdT18) to target sense RNA (rA18): development of a new in vitro assay

21 January 2018

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Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer, Macugen.

21 January 2018

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SELEX with modified nucleotides

21 January 2018

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Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

21 January 2018

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Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9.

21 January 2018

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Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

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Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

21 January 2018

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2'-Modified oligonucleotides for antisense therapeutics

21 January 2018

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Chemosensitization of gemcitabine-resistant human bladder cancer cell line both in vitro and in vivo using antisense oligonucleotide targeting the anti-apoptotic gene, clusterin

21 January 2018

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A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

21 January 2018

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Design of LNA probes that improve mismatch discrimination

21 January 2018

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Vivo-Morpholinos: a non-peptide transporter delivers Morpholinos into a wide array of mouse tissues

21 January 2018

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Inhibition of zebrafish fgf8 pre-mRNA splicing with morpholino oligos: a quantifiable method for gene knockdown.

21 January 2018

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Morpholino antisense oligomers: the case for an RNase H-independent structural type

21 January 2018

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Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

21 January 2018

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Knocking down barriers: advances in siRNA delivery

21 January 2018

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Recent advances with liposomes as pharmaceutical carriers

21 January 2018

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RNAi-mediated gene silencing in non-human primates.

21 January 2018

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Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

21 January 2018

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A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes

21 January 2018

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Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

21 January 2018

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Fomivirsen - a phosphorothioate oligonucleotide for the treatment of CMV retinitis

21 January 2018

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Topical delivery of interleukin-13 antisense oligonucleotides with cationic elastic liposome for the treatment of atopic dermatitis

21 January 2018

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Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species

21 January 2018

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Polymersome delivery of siRNA and antisense oligonucleotides.

21 January 2018

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Targeting the lung using siRNA and antisense based oligonucleotides.

21 January 2018

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Intranasal administration of CpG oligonucleotides induces mucosal and systemic Type 1 immune responses and adjuvant activity to porcine reproductive and respiratory syndrome killed virus vaccine in piglets in vivo

21 January 2018

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The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain.

21 January 2018

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Oral delivery of antisense oligonucleotides in man.

21 January 2018

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A competitive enzyme hybridization assay for plasma determination of phosphodiester and phosphorothioate antisense oligonucleotides

21 January 2018

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Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma

21 January 2018

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Appropriate calibration curve fitting in ligand binding assays

21 January 2018

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Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

21 January 2018

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Biochemical method for mapping mutational alterations in DNA with S1 nuclease: the location of deletions and temperature-sensitive mutations in simian virus 40

21 January 2018

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Mismatch cleavage by single-strand specific nucleases

21 January 2018

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Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range

21 January 2018

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Conjugation to polyethylene glycol polymer promotes aptamer biodistribution to healthy and inflamed tissues.

21 January 2018

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In vivo imaging of oligonucleotides with nuclear tomography.

21 January 2018

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Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats

21 January 2018

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Recent developments in mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and nucleic acids

21 January 2018

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Analysis of nucleic acids by on-line liquid chromatography-mass spectrometry

21 January 2018

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Quantification of raf antisense oligonucleotide (rafAON) in biological matrices by LC-MS/MS to support pharmacokinetics of a liposome-entrapped rafAON formulation

21 January 2018

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On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

21 January 2018

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Electrospray ionization mass spectrometry of oligonucleotide complexes with drugs, metals, and proteins.

21 January 2018

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Strategies for bioanalysis of an oligonucleotide class macromolecule from rat plasma using liquid chromatography-tandem mass spectrometry

21 January 2018

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Development of an ion-pair reverse-phase liquid chromatographic/tandem mass spectrometry method for the determination of an 18-mer phosphorothioate oligonucleotide in mouse liver tissue

21 January 2018

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Pharmacokinetics and biodistribution of novel aptamer compositions

21 January 2018

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Quantitative determination of short single-stranded oligonucleotides from blood plasma using capillary electrophoresis with laser-induced fluorescence

21 January 2018

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Analysis of nucleic acid constituents by on-line capillary electrophoresis-mass spectrometry

21 January 2018

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Competitive RT-PCR ELISA: a rapid, sensitive and non-radioactive method to quantitate cytokine mRNA.

21 January 2018

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Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs

21 January 2018

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Quantitation of microRNAs using a modified Invader assay

21 January 2018

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Absolute quantitation of microRNAs with a PCR-based assay.

21 January 2018

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Real-time quantification of microRNAs by stem-loop RT-PCR

21 January 2018

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Quantification of siRNA using competitive qPCR.

21 January 2018

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Recommendations for the bioanalytical method validation of ligand-binding assays to support pharmacokinetic assessments of macromolecules

21 January 2018

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Key elements of bioanalytical method validation for macromolecules

21 January 2018

1 reference

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race

21 January 2018

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Applications of Luminex xMAP technology for rapid, high-throughput multiplexed nucleic acid detection

21 January 2018

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Small interfering RNA and gene expression analysis using a multiplex branched DNA assay without RNA purification

21 January 2018

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Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice

21 January 2018

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A computational study of off-target effects of RNA interference

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/BIO.09.66

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23 August 2017

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