(Q37815124)

23 August 2017

1 reference

title

Haplo-insufficiency: a driving force in cancer (English)

1 reference

23 August 2017

2

Pier Paolo Pandolfi

0 references

author name string

Alice H Berger

series ordinal

1

1 reference

23 August 2017

publication date

29 October 2010

1 reference

23 August 2017

1 reference

23 August 2017

volume

223

1 reference

23 August 2017

issue

2

1 reference

23 August 2017

page(s)

137-146

1 reference

TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome

23 August 2017

cites work

1 reference

Oncogene amplification in solid tumors

21 January 2018

1 reference

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

21 January 2018

1 reference

Oncogenes and tumor suppressor genes.

21 January 2018

1 reference

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

21 January 2018

1 reference

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

21 January 2018

1 reference

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 January 2018

1 reference

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

Principles of tumor suppression

21 January 2018

1 reference

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors

21 January 2018

1 reference

Cancer-susceptibility genes. Gatekeepers and caretakers

21 January 2018

1 reference

p53 mutations in human cancers

21 January 2018

1 reference

Assessing TP53 status in human tumours to evaluate clinical outcome

21 January 2018

1 reference

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

21 January 2018

1 reference

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

21 January 2018

1 reference

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

21 January 2018

1 reference

The p53 tumour suppressor gene

21 January 2018

1 reference

The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

1 reference

Li-Fraumeni syndrome – a molecular and clinical review

21 January 2018

1 reference

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

1 reference

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

21 January 2018

1 reference

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

21 January 2018

1 reference

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

21 January 2018

1 reference

Loss of one p53 allele results in four-fold reduction of p53 mRNA and protein: a basis for p53 haplo-insufficiency

21 January 2018

1 reference

Tenets of PTEN tumor suppression

21 January 2018

1 reference

PTEN hamartoma tumor syndrome: an overview

21 January 2018

1 reference

Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation

21 January 2018

1 reference

PTEN/MMAC1 mutations in prostate cancer.

21 January 2018

1 reference

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

21 January 2018

1 reference

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

21 January 2018

1 reference

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

21 January 2018

1 reference

Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas

21 January 2018

1 reference

Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer

21 January 2018

1 reference

Dicer1 functions as a haploinsufficient tumor suppressor

21 January 2018

1 reference

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

21 January 2018

1 reference

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

21 January 2018

1 reference

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

1 reference

Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia

21 January 2018

1 reference

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

1 reference

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

1 reference

Identification of DOK genes as lung tumor suppressors

21 January 2018

1 reference

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

21 January 2018

1 reference

Role of nucleophosmin in embryonic development and tumorigenesis

21 January 2018

1 reference

Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression

21 January 2018

1 reference

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

Characterizing the cancer genome in lung adenocarcinoma

21 January 2018

1 reference

3p21.3 tumor suppressor cluster: prospects for translational applications

21 January 2018

1 reference

Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer

21 January 2018

1 reference

Myelodysplastic syndromes.

21 January 2018

1 reference

21 January 2018

1 reference

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

21 January 2018

1 reference

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

21 January 2018

1 reference

A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome

21 January 2018

1 reference

Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias

21 January 2018

1 reference

Subtle variations in Pten dose determine cancer susceptibility

21 January 2018

1 reference

Pten dose dictates cancer progression in the prostate

21 January 2018

1 reference

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21

21 January 2018

1 reference

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

21 January 2018

1 reference

Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse

21 January 2018

1 reference

Human haploinsufficiency — one for sorrow, two for joy

21 January 2018

1 reference

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.2800

1 reference

23 August 2017

1 reference