(Q37822317)

23 August 2017

1 reference

title

Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development (English)

1 reference

23 August 2017

0 references

1 reference

Eva Chung

1

1 reference

23 August 2017

Motonari Kondo

series ordinal

2

1 reference

23 August 2017

language of work or name

1 reference

1 April 2011

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23 August 2017

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23 August 2017

volume

49

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23 August 2017

issue

1-3

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23 August 2017

page(s)

248-268

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Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors.

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Hyperactive Ras in developmental disorders and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The structural basis of the activation of Ras by Sos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Raf kinases: function, regulation and role in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Targeting the mitogen-activated protein kinase cascade to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Distinct functions for ERKs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

p44 mitogen-activated protein kinase (extracellular signal-regulated kinase 1)-dependent signaling contributes to epithelial skin carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The N-terminal domain of ERK1 accounts for the functional differences with ERK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Regulation and role of Raf-1/B-Raf heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Phosphorylation and regulation of Raf by Akt (protein kinase B)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Regulation of Raf-Akt Cross-talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Function and regulation of ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The murine N-ras gene is not essential for growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Endothelial apoptosis in Braf-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Craf-1 protein kinase is essential for mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Targets of Raf in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Requirement for Map2k1 (Mek1) in extra-embryonic ectoderm during placentogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mek2 is dispensable for mouse growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mek1/2 MAPK kinases are essential for Mammalian development, homeostasis, and Raf-induced hyperplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Essential role for ERK2 mitogen-activated protein kinase in placental development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Cytokine receptor signal transduction and the control of hematopoietic cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

A critical function for B-Raf at multiple stages of myelopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Requirement of thrombopoietin-induced activation of ERK for megakaryocyte differentiation and of p38 for erythroid differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Raf-1 is not required for megakaryocytopoiesis or TPO-induced ERK phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Positive and negative selection invoke distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Selective requirement for MAP kinase activation in thymocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

The influence of the MAPK pathway on T cell lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Senescence of human fibroblasts induced by oncogenic Raf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic Kras initiates leukemia in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Endogenous K-ras signaling in erythroid differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Germline mutations in HRAS proto-oncogene cause Costello syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Oncogenic NRAS, KRAS, and HRAS exhibit different leukemogenic potentials in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Differential abilities of the Raf family of protein kinases to abrogate cytokine dependency and prevent apoptosis in murine hematopoietic cells by a MEK1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Differential abilities of activated Raf oncoproteins to abrogate cytokine dependency, prevent apoptosis and induce autocrine growth factor synthesis in human hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Effects of inducible MEK1 activation on the cytokine dependency of lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

A conditionally-active form of MEK1 results in autocrine tranformation of human and mouse hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

A synthetic inhibitor of the mitogen-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-010-8187-5

Involvement of p21ras distinguishes positive and negative selection in thymocytes

21 January 2018

1 reference

12 December 2020

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

12 December 2020

Raf proteins and cancer: B-Raf is identified as a mutational target

1 reference

12 December 2020

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1 reference

12 December 2020

Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

1 reference

12 December 2020

Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases

1 reference

12 December 2020

Negative regulation of the serine/threonine kinase B-Raf by Akt

1 reference

12 December 2020

Differential expression of MEK1 and MEK2 during mouse development

1 reference

12 December 2020

Cancer. Improved mouse models

1 reference

12 December 2020

Mutations in N-ras predominate in acute myeloid leukemia

1 reference

12 December 2020

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice

1 reference

12 December 2020

Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases

1 reference

12 December 2020

Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons

1 reference

12 December 2020

MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues.

1 reference

12 December 2020

Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line.

1 reference

12 December 2020

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

1 reference

12 December 2020

Mutations of the N-ras gene in juvenile chronic myelogenous leukemia

1 reference

12 December 2020

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

Cell-cycle-dependent activation of mitogen-activated protein kinase kinase (MEK-1/2) in myeloid leukemia cell lines and induction of growth inhibition and apoptosis by inhibitors of RAS signaling

1 reference

12 December 2020

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

1 reference

12 December 2020

Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system

1 reference

12 December 2020

Ras activation in normal white blood cells and childhood acute lymphoblastic leukemia.

1 reference

12 December 2020

Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

1 reference

12 December 2020

Involvement of B-Raf in Ras-induced Raf-1 activation

1 reference

12 December 2020

Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis

1 reference

12 December 2020

Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors.

1 reference

12 December 2020

Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation

1 reference

12 December 2020

Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis.

1 reference

12 December 2020

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction

1 reference

12 December 2020

Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?

1 reference

12 December 2020

Kinetic analysis of the hydrolysis of GTP by p21N-ras. The basal GTPase mechanism.

1 reference

12 December 2020

Degree of ERK activation influences both positive and negative thymocyte selection

1 reference

12 December 2020

10.1007/S12026-010-8187-5

Identifiers

DOI

1 reference

release_3m2xmatzrzdmzjdmxnmp4mchsq

23 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/3m2xmatzrzdmzjdmxnmp4mchsq

24 November 2022

mapped directly with Wikidata item

1 reference