(Q37837495)

24 August 2017

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title

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls (English)

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evasion of host immune response

24 August 2017

main subject

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inferred from title

author

Emmanuel J H J Wiertz

series ordinal

3

object named as

Emmanuel J H J Wiertz

1 reference

24 August 2017

2

Maaike E Ressing

1 reference

24 August 2017

Daniëlle Horst

1

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24 August 2017

publication date

8 February 2011

1 reference

Immunology & Cell Biology

24 August 2017

published in

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24 August 2017

volume

89

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24 August 2017

issue

3

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24 August 2017

page(s)

359-366

1 reference

https://scigraph.springernature.com/pub.10.1038/icb.2010.129

24 August 2017

exact match

0 references

cites work

The order Herpesvirales

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Viruses use stealth technology to escape from the host immune system

21 January 2018

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Viral immune evasion: a masterpiece of evolution

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Viral interference with antigen presentation

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Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

Herpesviruses and immunity: the art of evasion

21 January 2018

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Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Disulfide bond isomerization and the assembly of MHC class I-peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Insights into MHC Class I Peptide Loading from the Structure of the Tapasin-ERp57 Thiol Oxidoreductase Heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

Selective loading of high-affinity peptides onto major histocompatibility complex class I molecules by the tapasin-ERp57 heterodimer

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

Cross-priming in health and disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function

21 January 2018

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https://api.crossref.org/works/10.1038%2FICB.2010.129

Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Human herpesvirus-6A and -6B encode viral immunoevasins that downregulate class I MHC molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Varicella-zoster virus retains major histocompatibility complex class I proteins in the Golgi compartment of infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Downregulation of class I major histocompatibility complex surface expression by varicella-zoster virus involves open reading frame 66 protein kinase-dependent and -independent mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Human cytomegalovirus inhibits tapasin-dependent peptide loading and optimization of the MHC class I peptide cargo for immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A viral inhibitor of peptide transporters for antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Herpes simplex virus turns off the TAP to evade host immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A viral ER-resident glycoprotein inactivates the MHC-encoded peptide transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The human cytomegalovirus gene product US6 inhibits ATP binding by TAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Gamma-herpesvirus latency requires T cell evasion during episome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

MHC class I ubiquitination by a viral PHD/LAP finger protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Murine cytomegalovirus interference with antigen presentation has little effect on the size or the effector memory phenotype of the CD8 T cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Recombinant gp350 vaccine for infectious mononucleosis: a phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Zoster vaccine (Zostavax): a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Pathogenesis of herpes simplex virus type 2 virion host shutoff (vhs) mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Disruption of the U(L)41 gene in the herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Disruption of virion host shutoff activity improves the immunogenicity and protective capacity of a replication-incompetent herpes simplex virus type 1 vaccine strain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Construction and properties of a herpes simplex virus 2 dl5-29 vaccine candidate strain encoding an HSV-1 virion host shutoff protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Genetic engineering of a modified herpes simplex virus 1 vaccine vector.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of her

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

PKR, apoptosis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The role of translation in neoplastic transformation from a pathologist's point of view

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Oncolytic herpes simplex virus vector g47delta in combination with androgen ablation for the treatment of human prostate adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Herpes simplex virus as an in situ cancer vaccine for the induction of specific anti-tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

MHC class I antigens, immune surveillance, and tumor immune escape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

How not to be seen: immune-evasion strategies in gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Expression of herpes simplex virus ICP47 and human cytomegalovirus US11 prevents recognition of transgene products by CD8(+) cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Adenoviral vector expressing ICP47 inhibits adenovirus-specific cytotoxic T lymphocytes in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Characterization of an immuno 'stealth' derivative of the herpes simplex virus thymidine-kinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic beta-cells to correct diabetes in allogeneic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Down-regulation of MHC class I expression in human neuronal stem cells using viral stealth mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

MHC expression in a human adult stem cell line and its down-regulation by hCMV US gene transfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Exploiting virus stealth technology for xenotransplantation: reduced human T cell responses to porcine cells expressing herpes simplex virus ICP47.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Simultaneous infection of healthy people with multiple human cytomegalovirus strains

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Live attenuated varicella vaccine

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

The second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alpha

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Subversion of host defense mechanisms by adenoviruses.

1 reference

https://api.crossref.org/works/10.1038%2FICB.2010.129

7 January 2021

Identifiers

DOI

10.1038/ICB.2010.129

1 reference

Dimensions Publication ID

24 August 2017

1037871664

0 references

1 reference