(Q37843473)

24 August 2017

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title

Heterochromatin and the DNA damage response: the need to relax (English)

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24 August 2017

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Graham Dellaire

2

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author name string

Kendra L Cann

series ordinal

1

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24 August 2017

publication date

1 February 2011

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Biochemistry and Cell Biology

24 August 2017

published in

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24 August 2017

volume

89

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24 August 2017

issue

1

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24 August 2017

page(s)

45-60

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Putting a KAP on transcription and stress

24 August 2017

cites work

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Role of A-type lamins in signaling, transcription, and chromatin organization.

21 January 2018

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Five repair pathways in one context: chromatin modification during DNA repair

21 January 2018

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HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

21 January 2018

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Paving the way for H2AX phosphorylation: chromatin changes in the DNA damage response.

21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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Residual gammaH2AX foci as an indication of lethal DNA lesions

21 January 2018

1 reference

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

21 January 2018

1 reference

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

1 reference

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

21 January 2018

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Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair.

21 January 2018

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Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

21 January 2018

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The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells.

21 January 2018

1 reference

The nuclear lamina. Both a structural framework and a platform for genome organization

21 January 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

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Histones: annotating chromatin

21 January 2018

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Regulation of the cellular DNA double-strand break response

21 January 2018

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Genomic instability in mice lacking histone H2AX

21 January 2018

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

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Physical interaction between the histone acetyl transferase Tip60 and the DNA double-strand breaks sensor MRN complex.

21 January 2018

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

21 January 2018

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Chromatin modulation and the DNA damage response

21 January 2018

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gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

21 January 2018

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21 January 2018

Chromosome territories

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Organization of chromatin in the interphase mammalian cell

21 January 2018

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PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

21 January 2018

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Beyond repair foci: subnuclear domains and the cellular response to DNA damage

21 January 2018

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Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.

21 January 2018

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High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci

21 January 2018

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DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization.

21 January 2018

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Linking Heterochromatin Protein 1 (HP1) to cancer progression

21 January 2018

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The emerging role of HP1 in the DNA damage response

21 January 2018

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

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ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation

21 January 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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Chromatin dynamics during DSB repair

21 January 2018

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Chromatin structure influences the sensitivity of DNA to gamma-radiation

21 January 2018

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Higher-order chromatin structure in DSB induction, repair and misrepair

21 January 2018

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Controlling the double helix

21 January 2018

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

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Epigenetics regulate centromere formation and kinetochore function.

21 January 2018

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

21 January 2018

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The impact of heterochromatin on DSB repair

21 January 2018

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DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

21 January 2018

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Type II topoisomerases--inhibitors, repair mechanisms and mutations

21 January 2018

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FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

21 January 2018

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Genome maintenance mechanisms for preventing cancer

21 January 2018

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Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis

21 January 2018

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A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors

21 January 2018

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

21 January 2018

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DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

21 January 2018

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Perturbation of HP1 localization and chromatin binding ability causes defects in sister-chromatid cohesion.

21 January 2018

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PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing

21 January 2018

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Radiation-induced DNA damage responses

21 January 2018

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The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

21 January 2018

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Double-strand breaks: signaling pathways and repair mechanisms.

21 January 2018

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Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments.

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals

21 January 2018

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Chromatin modifications and their function

21 January 2018

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Involvement of novel autophosphorylation sites in ATM activation

21 January 2018

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

21 January 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

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Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions

21 January 2018

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Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential

21 January 2018

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The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

21 January 2018

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Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells

21 January 2018

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Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

21 January 2018

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gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

21 January 2018

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

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PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase.

21 January 2018

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Heterochromatin protein 1 is recruited to various types of DNA damage.

21 January 2018

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

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HP1 and the dynamics of heterochromatin maintenance

21 January 2018

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The emerging role of nuclear architecture in DNA repair and genome maintenance

21 January 2018

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Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes.

21 January 2018

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Global chromatin compaction limits the strength of the DNA damage response

21 January 2018

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Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks

21 January 2018

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PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

21 January 2018

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DNA damage checkpoints in mammals

21 January 2018

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53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

21 January 2018

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Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development

21 January 2018

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Regulatory ubiquitylation in response to DNA double-strand breaks

21 January 2018

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The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

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Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

21 January 2018

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Heterochromatic genome stability requires regulators of histone H3 K9 methylation

21 January 2018

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The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

21 January 2018

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DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

21 January 2018

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

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The structure of DNA in the nucleosome core

21 January 2018

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The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

21 January 2018

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Pathways of DNA double-strand break repair during the mammalian cell cycle

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

21 January 2018

1 reference

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

21 January 2018

1 reference

Human Heterochromatin Protein 1 Isoforms HP1Hsα and HP1Hsβ Interfere with hTERT-Telomere Interactions and Correlate with Changes in Cell Growth and Response to Ionizing Radiation

21 January 2018

1 reference

The interacting pathways for prevention and repair of oxidative DNA damage

21 January 2018

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The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

21 January 2018

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 January 2018

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A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

21 January 2018

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DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity

21 January 2018

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Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

21 January 2018

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Tip60: connecting chromatin to DNA damage signaling

21 January 2018

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The RAD51 gene family, genetic instability and cancer

21 January 2018

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The nuclear envelope--a scaffold for silencing?

21 January 2018

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Higher-order structures of chromatin: the elusive 30 nm fiber

21 January 2018

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Facultative heterochromatin: is there a distinctive molecular signature?

21 January 2018

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Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

21 January 2018

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ATP-dependent chromatin remodeling facilitates nucleotide excision repair of UV-induced DNA lesions in synthetic dinucleosomes

21 January 2018

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End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4.

21 January 2018

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Chromatin fiber structure: Where is the problem now?

21 January 2018

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Evidence for the receipt of DNA damage stimuli by PML nuclear domains

21 January 2018

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gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci

21 January 2018

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Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

21 January 2018

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The octameric histone core of the nucleosome. Structural issues resolved.

21 January 2018

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

21 January 2018

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KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions

21 January 2018

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Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

21 January 2018

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21 January 2018

DNA repair in eukaryotes

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Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling

21 January 2018

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Recruitment of heterochromatin protein 1 to DNA repair sites.

21 January 2018

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Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing

21 January 2018

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HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

21 January 2018

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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

21 January 2018

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O10-113

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24 August 2017

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