(Q34722112)

4 August 2017

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title

Regulation of the cellular DNA double-strand break response (English)

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4 August 2017

Kendra L Cann

1

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PubMed ID

18059525

4 August 2017

Geoffrey G Hicks

series ordinal

2

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4 August 2017

1 December 2007

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Biochemistry and Cell Biology

4 August 2017

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4 August 2017

85

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4 August 2017

6

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4 August 2017

663-674

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Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination

4 August 2017

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Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

21 January 2018

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DNA damage responses and their many interactions with the replication fork

21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

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Mammalian G1- and S-phase checkpoints in response to DNA damage

21 January 2018

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Pathways governing G1/S transition and their response to DNA damage

21 January 2018

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Checking on DNA damage in S phase

21 January 2018

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Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

21 January 2018

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DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

21 January 2018

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The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

21 January 2018

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The switch from survival responses to apoptosis after chromosomal breaks

21 January 2018

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

21 January 2018

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Genomic instability in mice lacking histone H2AX

21 January 2018

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

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Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl

21 January 2018

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

21 January 2018

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Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage.

21 January 2018

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ATR and ATRIP: partners in checkpoint signaling

21 January 2018

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Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.

21 January 2018

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

21 January 2018

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

21 January 2018

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p53-Dependent regulation of Cdc6 protein stability controls cellular proliferation

21 January 2018

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The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

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Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

21 January 2018

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A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

21 January 2018

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

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MDC1 is required for the intra-S-phase DNA damage checkpoint

21 January 2018

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

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Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes

21 January 2018

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Dna repair: Rad52 - the means to an end.

21 January 2018

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Genome maintenance mechanisms for preventing cancer

21 January 2018

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Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

21 January 2018

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Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage

21 January 2018

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Replication Protein A (RPA): The Eukaryotic SSB

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Interstrand crosslink-induced homologous recombination carries an increased risk of deletions and insertions.

21 January 2018

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Double-strand breaks: signaling pathways and repair mechanisms.

21 January 2018

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Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

21 January 2018

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Cell-cycle checkpoints and cancer

21 January 2018

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DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

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Involvement of novel autophosphorylation sites in ATM activation

21 January 2018

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Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

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DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

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Radiation down-regulates replication origin activity throughout the S phase in mammalian cells

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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Sensing, signaling, and responding to DNA damage: organization of the checkpoint pathways in mammalian cells

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

21 January 2018

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

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p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

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CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis

21 January 2018

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Rapid destruction of human Cdc25A in response to DNA damage

21 January 2018

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Control of replication origin density and firing time in Xenopus egg extracts: role of a caffeine-sensitive, ATR-dependent checkpoint.

21 January 2018

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Effects of p53 mutations on cellular sensitivity to ionizing radiation

21 January 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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Regulation of cellular and SV40 virus origins of replication by Chk1-dependent intrinsic and UVC radiation-induced checkpoints

21 January 2018

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Rapid activation of ATR by ionizing radiation requires ATM and Mre11

21 January 2018

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DNA damage checkpoints in mammals

21 January 2018

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Regulation of cyclin-Cdk activity in mammalian cells

21 January 2018

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Dynamic organization of DNA replication in mammalian cell nuclei: spatially and temporally defined replication of chromosome-specific alpha-satellite DNA sequences

21 January 2018

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Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

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The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

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Emerging functions of BRCA2 in DNA recombination

21 January 2018

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DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

21 January 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

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Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells

21 January 2018

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Transcription, apoptosis and p53: catch-22.

21 January 2018

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

21 January 2018

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ATR and ATM regulate the timing of DNA replication origin firing

21 January 2018

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Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint

21 January 2018

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The cellular response to p53: the decision between life and death

21 January 2018

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ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage

21 January 2018

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Genetic steps of mammalian homologous repair with distinct mutagenic consequences

21 January 2018

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MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

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Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation

21 January 2018

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The RAD51 gene family, genetic instability and cancer

21 January 2018

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Double-strand break repair mediated by DNA end-joining.

21 January 2018

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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

21 January 2018

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The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

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Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

21 January 2018

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

21 January 2018

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Initial steps of ferulic acid polymerization by lignin peroxidase

21 January 2018

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Structural basis for phosphorylation-dependent signaling in the DNA-damage response

21 January 2018

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p21 is a universal inhibitor of cyclin kinases

21 January 2018

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Dual roles of ATM in the cellular response to radiation and in cell growth control.

21 January 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

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Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation

21 January 2018

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Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage

21 January 2018

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Regulation of Rad51 function by c-Abl in response to DNA damage

21 January 2018

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Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells

21 January 2018

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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair

21 January 2018

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MDC1 interacts with Rad51 and facilitates homologous recombination

21 January 2018

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

21 January 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 January 2018

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Distinct Initiation and Maintenance Mechanisms Cooperate to Induce G1 Cell Cycle Arrest in Response to DNA Damage

21 January 2018

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21 January 2018

The Cell Cycle: A Review

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Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1139/O07-135

1 reference

4 August 2017

1 reference

PubMed ID

18059525