(Q37846139)

24 August 2017

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title

Genetic variability of pain perception and treatment--clinical pharmacological implications (English)

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24 August 2017

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Jörn Lötsch

1

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language of work or name

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23 February 2011

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European Journal of Clinical Pharmacology

24 August 2017

published in

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24 August 2017

volume

67

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24 August 2017

issue

6

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24 August 2017

page(s)

541-551

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Genetic modulation of the pharmacological treatment of pain

24 August 2017

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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence

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Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain

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Cross-sectional assessment of the consequences of a GTP cyclohydrolase 1 haplotype for specialized tertiary outpatient pain care

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A GTP cyclohydrolase 1 genetic variant delays cancer pain

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Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans

21 January 2018

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Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?

21 January 2018

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Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk

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Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

21 January 2018

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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1

21 January 2018

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TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?

21 January 2018

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Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

21 January 2018

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Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

21 January 2018

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Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research

21 January 2018

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Current evidence for a genetic modulation of the response to analgesics

21 January 2018

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Are mu-opioid receptor polymorphisms important for clinical opioid therapy?

21 January 2018

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Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery

21 January 2018

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A common human micro-opioid receptor genetic variant diminishes the receptor signaling efficacy in brain regions processing the sensory information of pain

21 January 2018

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Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G.

21 January 2018

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Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction

21 January 2018

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Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?

21 January 2018

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Meta-analysis of the relevance of the OPRM1 118A>G genetic variant for pain treatment

21 January 2018

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Sequence Variability and Candidate Gene Analysis in Two Cancer Patients with Complex Clinical Outcomes During Morphine Therapy

21 January 2018

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The mu-opioid receptor gene polymorphism 118A>G depletes alfentanil-induced analgesia and protects against respiratory depression in homozygous carriers

21 January 2018

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Expansion of the human mu-opioid receptor gene architecture: novel functional variants

21 January 2018

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A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

21 January 2018

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COMT Val108/158Met genotype affects the mu-opioid receptor system in the human brain: evidence from ligand-binding, G-protein activation and preproenkephalin mRNA expression

21 January 2018

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COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

21 January 2018

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21 January 2018

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Analgesic targets: today and tomorrow

21 January 2018

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Targeting voltage-gated sodium channels for pain therapy

21 January 2018

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Transient receptor potential channels: targeting pain at the source

21 January 2018

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Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia

21 January 2018

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Heritability of responses to painful stimuli in women: a classical twin study

21 January 2018

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A new Nav1.7 sodium channel mutation I234T in a child with severe pain

21 January 2018

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A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

21 January 2018

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Compound heterozygosity in sodium channel Nav1.7 in a family with hereditary erythermalgia

21 January 2018

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A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome

21 January 2018

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21 January 2018

Drosophila TRP channels.

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ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

21 January 2018

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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

21 January 2018

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How cold is it? TRPM8 and TRPA1 in the molecular logic of cold sensation

21 January 2018

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A TRP channel that senses cold stimuli and menthol

21 January 2018

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Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother

21 January 2018

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Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations

21 January 2018

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Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizer

21 January 2018

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Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?

21 January 2018

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Codeine intoxication associated with ultrarapid CYP2D6 metabolism

21 January 2018

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Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief.

21 January 2018

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Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers

21 January 2018

1 reference

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ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals

21 January 2018

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Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans

21 January 2018

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Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin

21 January 2018

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Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

21 January 2018

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Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence

21 January 2018

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A genetic association study of the mu opioid receptor and severe opioid dependence

21 January 2018

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Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse.

21 January 2018

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Haplotypes at the OPRM1 locus are associated with susceptibility to substance dependence in European-Americans

21 January 2018

1 reference

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Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution

21 January 2018

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Association between the DRD2 A1 allele and response to methadone and buprenorphine maintenance treatments

21 January 2018

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Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction

21 January 2018

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The genetics of addictions: uncovering the genes

21 January 2018

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Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

21 January 2018

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Current evidence for a modulation of nociception by human genetic polymorphisms

21 January 2018

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The gene for hereditary sensory neuropathy type I (HSN-I) maps to chromosome 9q22.1-q22.3.

21 January 2018

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SPTLC1 is mutated in hereditary sensory neuropathy, type 1

21 January 2018

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Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

A mutation in the HSN2 gene causes sensory neuropathy type II in a Lebanese family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Localization of the gene for familial dysautonomia on chromosome 9 and definition of DNA markers for genetic diagnosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00228-011-1012-9

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

21 January 2018

1 reference

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[Phenotypic manifestations and genetic features of migraine]

21 January 2018

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12 December 2020

Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain

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12 December 2020

A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V.

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12 December 2020

Are we getting anywhere in human pain genetics?

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12 December 2020

A critical appraisal of human genotyping for pain therapy

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12 December 2020

[Duality of the analgesic effect of tramadol in humans]

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12 December 2020

Pain perception is altered by a nucleotide polymorphism in SCN9A

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12 December 2020

Complete paternal uniparental isodisomy for chromosome 1 revealed by mutation analyses of the TRKA (NTRK1) gene encoding a receptor tyrosine kinase for nerve growth factor in a patient with congenital insensitivity to pain with anhidrosis

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12 December 2020

Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine

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12 December 2020

Genetically mediated interindividual variation in analgesic responses to cyclooxygenase inhibitory drugs

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12 December 2020

Transient receptor potential channels on sensory nerves

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12 December 2020

The pathway from GTP to tetrahydrobiopterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase

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12 December 2020

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

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12 December 2020

Long-term open-label study of tanezumab for moderate to severe osteoarthritic knee pain

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12 December 2020

Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine

1 reference

12 December 2020

10.1007/S00228-011-1012-9

Identifiers

DOI

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release_5h5x62n3yvafnhpfdviz446neu

24 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/5h5x62n3yvafnhpfdviz446neu

24 November 2022

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