(Q37855922)

24 August 2017

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title

Autophagy: cancer therapy's friend or foe? (English)

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24 August 2017

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Theocharis Panaretakis

object named as

Theocharis Panaretakis

series ordinal

2

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author name string

Dan Grandér

series ordinal

1

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24 August 2017

1 February 2010

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Future Medicinal Chemistry

24 August 2017

1 reference

24 August 2017

2

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24 August 2017

2

1 reference

24 August 2017

285-297

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Autophagy in the Pathogenesis of Disease

24 August 2017

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Life and death partners: apoptosis, autophagy and the cross-talk between them

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The paradox of autophagy and its implication in cancer etiology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy genes in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy defends cells against invading group A Streptococcus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Protein degradation and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Apoptosis and autophagy in photoreceptors exposed to oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy in aging, disease and death: the true identity of a cell death impostor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy suppresses tumorigenesis through elimination of p62

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy: in sickness and in health

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Role of autophagy in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

AMPK/SNF1 structure: a menage a trois of energy-sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

A ubiquitin-like system mediates protein lipidation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

PUMA- and Bax-induced autophagy contributes to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Stimulation of autophagy by the p53 target gene Sestrin2.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Regulation of autophagy by cytoplasmic p53

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The ARF tumor suppressor can promote the progression of some tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

ARF, autophagy and tumor suppression.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Therapeutic activity of mTOR inhibitors in mantle cell lymphoma: clues but no clear answers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Apoptosis inhibition by Bcl-2 gives way to autophagy in glucocorticoid-treated lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Superoxide is the major reactive oxygen species regulating autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

ROS, mitochondria and the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Oxidation as a post-translational modification that regulates autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Autophagy facilitates the progression of ERalpha-positive breast cancer cells to antiestrogen resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Regulation of estrogenic effects by beclin 1 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Vitamin D3 induces autophagy of human myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The Bcr-Abl kinase inhibitor INNO-406 induces autophagy and different modes of cell death execution in Bcr-Abl-positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

FoxO3 controls autophagy in skeletal muscle in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Metabolic profiles of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Early detection of graft failure using the blood metabolic profile of a liver recipient

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Clinical applications of metabolomics in oncology: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Arsenic salts induced autophagic cell death and hypermethylation of DAPK promoter in SV-40 immortalized human uroepithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

Chronic Lymphocytic Leukemia: Keeping Cell Death at Bay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.09.155

21 January 2018

Identifiers

DOI

10.4155/FMC.09.155

1 reference

24 August 2017

1 reference

PubMed ID

21426194