(Q37856259)

24 August 2017

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title

A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation (English)

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24 August 2017

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Rocio Vila-Bedmar

1

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24 August 2017

Sonia Fernández-Veledo

series ordinal

2

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24 August 2017

publication date

23 March 2011

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Archives of Physiology and Biochemistry

24 August 2017

published in

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24 August 2017

volume

117

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24 August 2017

issue

3

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24 August 2017

page(s)

195-208

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Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice

24 August 2017

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Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore

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The role of MAPKs in adipocyte differentiation and obesity.

21 January 2018

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Detection of brown adipose tissue uncoupling protein mRNA in adult patients by a human genomic probe

21 January 2018

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Rb regulates fate choice and lineage commitment in vivo

21 January 2018

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Brown adipose tissue: function and physiological significance

21 January 2018

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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

21 January 2018

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Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta

21 January 2018

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Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth

21 January 2018

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FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance

21 January 2018

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Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs

21 January 2018

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Regulation of adipocyte differentiation and insulin action with rapamycin.

21 January 2018

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21 January 2018

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A reservoir of brown adipocyte progenitors in human skeletal muscle.

21 January 2018

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Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A

21 January 2018

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Identification and importance of brown adipose tissue in adult humans

21 January 2018

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AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes

21 January 2018

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Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha

21 January 2018

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Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Bi-directional regulation of brown fat adipogenesis by the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Distribution and development of brown adipocytes in the murine and human adipose organ

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

The effects of AICAR on adipocyte differentiation of 3T3-L1 cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Regulatory circuits controlling white versus brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

LXRs regulate the balance between fat storage and oxidation.

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Brown vs white adipocytes: the PPARgamma coregulator story

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice

21 January 2018

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A critical appraisal of the prevalence and metabolic significance of brown adipose tissue in adult humans

21 January 2018

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https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Differentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Nuclear receptor corepressor RIP140 regulates fat accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

The effect of intermittent cold treatment on the adipose tissue of the cat. Apparent transformation from white to brown adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Insulin resistance induced by tumor necrosis factor-alpha in myocytes and brown adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Increased insulin sensitivity in IGF-I receptor--deficient brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Unexpected evidence for active brown adipose tissue in adult humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

PRDM16 controls a brown fat/skeletal muscle switch

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Transcriptional control of brown fat determination by PRDM16

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Gene expression in human brown adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Acquirement of brown fat cell features by human white adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Fat and beyond: the diverse biology of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Differential roles of insulin receptor substrates in brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Cold-activated brown adipose tissue in healthy men

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Functional brown adipose tissue in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Method for decreasing uptake of 18F-FDG by hypermetabolic brown adipose tissue on PET.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Reversing adipocyte differentiation: implications for treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

Cidea-deficient mice have lean phenotype and are resistant to obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F13813455.2011.560951

10.3109/13813455.2011.560951

21 January 2018

Identifiers

DOI

1 reference

24 August 2017

1 reference