(Q37861028)

24 August 2017

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title

Inherited mutations in breast cancer genes--risk and response (English)

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24 August 2017

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William David Foulkes

series ordinal

2

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24 August 2017

Andrew Y Shuen

1

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24 August 2017

publication date

5 April 2011

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Journal of Mammary Gland Biology and Neoplasia

24 August 2017

published in

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24 August 2017

volume

16

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24 August 2017

issue

1

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24 August 2017

page(s)

3-15

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BRCA1 and BRCA2: 1994 and beyond

24 August 2017

cites work

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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BRCA1 and its toolbox for the maintenance of genome integrity

21 January 2018

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

21 January 2018

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BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair

21 January 2018

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The transcriptional corepressor CtBP: a foe of multiple tumor suppressors

21 January 2018

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Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensor

21 January 2018

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

21 January 2018

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

21 January 2018

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The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction

21 January 2018

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Recombination mediator and Rad51 targeting activities of a human BRCA2 polypeptide.

21 January 2018

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Purified human BRCA2 stimulates RAD51-mediated recombination

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Evidence for SMAD3 as a modifier of breast cancer risk in BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Association of the variants CASP8 D302H and CASP10 V410I with breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common variants associated with breast cancer in genome-wide association studies are modifiers of breast cancer risk in BRCA1 and BRCA2 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common genetic variants and modification of penetrance of BRCA2-associated breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Performance of common genetic variants in breast-cancer risk models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Genome-wide association study identifies five new breast cancer susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Susceptibility pathways in Fanconi's anemia and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

CHEK2 variant I157T may be associated with increased breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Nijmegen Breakage Syndrome mutations and risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Penetrance analysis of the PALB2 c.1592delT founder mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A PALB2 mutation associated with high risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Rare, evolutionarily unlikely missense substitutions in ATM confer increased risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

CHEK2 is a multiorgan cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

PALB2/FANCN: Recombining Cancer and Fanconi Anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Biallelic inactivation of BRCA2 in Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A recurrent mutation in PALB2 in Finnish cancer families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Analysis of PALB2/FANCN-associated breast cancer families

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Analysis of the gene coding for the BRCA2-interacting protein PALB2 in familial and sporadic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Mutation of the RAD51C gene in a Fanconi anemia-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

RAD51C germline mutations in breast and ovarian cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Screening RAD51C nucleotide alterations in patients with a family history of breast and ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Mutations of the SLX4 gene in Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Time to check CHEK2 in families with breast cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Genome-wide association study identifies novel breast cancer susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Functional enhancers at the gene-poor 8q24 cancer-linked locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Triple-Negative Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

BRCA1 dysfunction in sporadic basal-like breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Negative Regulation of BRCA1 Gene Expression by HMGA1 Proteins Accounts for the Reduced BRCA1 Protein Levels in Sporadic Breast Carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Iniparib plus chemotherapy in metastatic triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

A common coding variant in CASP8 is associated with breast cancer risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Traffic Control for BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10911-011-9213-5

Increased risk of breast cancer associated with CHEK2*1100delC

21 January 2018

1 reference

12 December 2020

Germline RAP80 mutations and susceptibility to breast cancer

1 reference

12 December 2020

Malignant neoplasms in the families of patients with ataxia-telangiectasia

1 reference

12 December 2020

Polygenes, risk prediction, and targeted prevention of breast cancer

1 reference

12 December 2020

CHEK2 Mutation and Hereditary Breast Cancer

1 reference

12 December 2020

Germline mutations 657del5 of the NBS1 gene contribute significantly to the incidence of breast cancer in Central Poland

1 reference

12 December 2020

BRCA1 expression in triple negative sporadic breast cancers.

1 reference

12 December 2020

Genetic risk prediction--are we there yet?

1 reference

12 December 2020

Regulation of corepressor function by nuclear NADH.

1 reference

12 December 2020

Association of two mutations in theCHEK2 gene with breast cancer

1 reference

12 December 2020

Variation of breast cancer risk among BRCA1/2 carriers

1 reference

12 December 2020

A deletion in CHEK2 of 5,395 bp predisposes to breast cancer in Poland

1 reference

12 December 2020

10.1007/S10911-011-9213-5

Identifiers

DOI

1 reference

24 August 2017

1 reference