(Q34722732)

4 August 2017

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title

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks (English)

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4 August 2017

Lavin MF

1

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4 August 2017

language of work or name

English

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publication date

1 December 2007

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4 August 2017

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4 August 2017

volume

26

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4 August 2017

issue

56

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4 August 2017

page(s)

7749-7758

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210880

4 August 2017

exact match

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cites work

Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

DNA double-strand break repair and chromosome translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Active role for nibrin in the kinetics of atm activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Nijmegen breakage syndrome: consequences of defective DNA double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Ku, a DNA repair protein with multiple cellular functions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Ataxia telangiectasia mutated expression and activation in the testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Involvement of novel autophosphorylation sites in ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Systematic Discovery of In Vivo Phosphorylation Networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

DNA repair: keeping it together

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

In vitro and in vivo studies on the generation of the primary T-cell receptor repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Cellular responses to DNA damage: current state of the field and review of the 52nd Benzon Symposium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Using quantitative imaging microscopy to define the target substrate specificities of histone post-translational-modifying enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The DNA-dependent protein kinase: the director at the end.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

DNA damage-dependent nuclear dynamics of the Mre11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The ATR pathway: fine-tuning the fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Interplay between human DNA repair proteins at a unique double-strand break in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Strain-specific responses of inbred mice to ethanol following food shortage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

A chromatin remodelling complex involved in transcription and DNA processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The ATM-mediated DNA-damage response: taking shape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Rad50S alleles of the Mre11 complex: questions answered and questions raised

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Regulation and mechanisms of mammalian double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Protein phosphatase 5 is required for ATR-mediated checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

Mechanism and control of V(D)J recombination versus class switch recombination: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

7 January 2021

Interleukin-4 receptor signalling mechanisms and their biological significance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

7 January 2021

Biochemistry of DNA lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210880

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210880

1 reference

Dimensions Publication ID

4 August 2017

1045150646

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1 reference