(Q37869444)

24 August 2017

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title

Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer (English)

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24 August 2017

main subject

multiple drug resistance

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Meysam Abbasi

1

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24 August 2017

Afsaneh Lavasanifar

series ordinal

2

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24 August 2017

Hasan Uludag

series ordinal

3

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24 August 2017

publication date

26 April 2011

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Medicinal Research Reviews

24 August 2017

published in

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24 August 2017

volume

33

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24 August 2017

issue

1

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24 August 2017

page(s)

33-53

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Molecular and physiologic mechanisms of drug resistance in cancer: an overview.

24 August 2017

cites work

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ABC efflux pump-based resistance to chemotherapy drugs.

21 January 2018

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Multiple drug resistance mechanisms in cancer

21 January 2018

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Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

21 January 2018

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

21 January 2018

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Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein

21 January 2018

1 reference

Extraction of Hoechst 33342 from the cytoplasmic leaflet of the plasma membrane by P-glycoprotein.

21 January 2018

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The occluded nucleotide conformation of p-glycoprotein

21 January 2018

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How can we best use structural information on P-glycoprotein to design inhibitors?

21 January 2018

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P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement

21 January 2018

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Regulation of the stability of P-glycoprotein by ubiquitination

21 January 2018

1 reference

Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer--an evolving story

21 January 2018

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Transcriptional repression of protein kinase Calpha via Sp1 by wild type p53 is involved in inhibition of multidrug resistance 1 P-glycoprotein phosphorylation

21 January 2018

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Review of the application of RNA interference technology in the pharmaceutical industry

21 January 2018

1 reference

Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing

21 January 2018

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The application of siRNA technology to cancer biology discovery

21 January 2018

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Mechanistic insights aid computational short interfering RNA design.

21 January 2018

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Rational siRNA design for RNA interference

21 January 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

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Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells

21 January 2018

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In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug

21 January 2018

1 reference

MicroRNA function: multiple mechanisms for a tiny RNA?

21 January 2018

1 reference

Hammerhead ribozyme design and application

21 January 2018

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Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

21 January 2018

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Complete reversal of multidrug resistance by stable expression of small interfering RNAs targeting MDR1.

21 January 2018

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Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

21 January 2018

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siRNA function in RNAi: a chemical modification analysis

21 January 2018

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In vivo activity of nuclease-resistant siRNAs

21 January 2018

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Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

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Interferon-alpha and interleukin-12 are induced differentially by Toll-like receptor 7 ligands in human blood dendritic cell subsets

21 January 2018

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

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RNA interference in biology and disease

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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JNK2 and IKKbeta are required for activating the innate response to viral infection

21 January 2018

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Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

21 January 2018

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Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

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Specificity of short interfering RNA determined through gene expression signatures

21 January 2018

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Reversal of MDR1 gene-dependent multidrug resistance using low concentration of endonuclease-prepared small interference RNA.

21 January 2018

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Modulation of the efficiency of a siRNA directed against MDR1 expression in MCF7-R cells when combined with a second siRNA.

21 January 2018

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Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

21 January 2018

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Cationic polymer-mediated small interfering RNA delivery for P-glycoprotein down-regulation in tumor cells.

21 January 2018

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RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

21 January 2018

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Nonviral delivery of synthetic siRNAs in vivo

21 January 2018

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The silent treatment: siRNAs as small molecule drugs

21 January 2018

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A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy

21 January 2018

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Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.

21 January 2018

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Formulation and delivery of siRNA by oleic acid and stearic acid modified polyethylenimine.

21 January 2018

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Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery

21 January 2018

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Virus-mimetic polymeric micelles for targeted siRNA delivery

21 January 2018

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Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel

21 January 2018

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In vivo reversal of P-glycoprotein-mediated multidrug resistance by efficient delivery of stealth RNAi

21 January 2018

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The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy

21 January 2018

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The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance.

21 January 2018

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Design and cloning strategies for constructing shRNA expression vectors

21 January 2018

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In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein

21 January 2018

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Reversal of multidrug resistance by small interfering double-stranded RNAs in ovarian cancer cells

21 January 2018

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High-efficiency system for the construction of adenovirus vectors and its application to the generation of representative adenovirus-based cDNA expression libraries

21 January 2018

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Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector

21 January 2018

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Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line

21 January 2018

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Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference

21 January 2018

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Complete in vivo reversal of the multidrug resistance phenotype by jet-injection of anti-MDR1 short hairpin RNA-encoding plasmid DNA.

21 January 2018

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Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance

21 January 2018

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Simultaneous targeting of MCL1 and ABCB1 as a novel strategy to overcome drug resistance in human leukaemia

21 January 2018

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siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells

21 January 2018

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Proteasome inhibitor MG132 reverses multidrug resistance of gastric cancer through enhancing apoptosis and inhibiting P-gp

21 January 2018

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RPN2 gene confers docetaxel resistance in breast cancer

21 January 2018

1 reference

In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MED.20244

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24 August 2017

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