(Q37871552)

24 August 2017

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title

TGFβ signaling and congenital heart disease: Insights from mouse studies (English)

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24 August 2017

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congenital heart disease

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Simon D Bamforth

2

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Helen M. Arthur

object named as

Helen M Arthur

series ordinal

1

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publication date

28 April 2011

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Birth Defects Research Part A: Clinical and Molecular Teratology

24 August 2017

published in

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24 August 2017

volume

91

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24 August 2017

issue

6

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24 August 2017

page(s)

423-434

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Generation of a floxed allele of the mouse Endoglin gene

24 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor beta in cardiovascular development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Generation of mice with a conditional allele for transforming growth factor beta 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

A population-based study of the 22q11.2 deletion: phenotype, incidence, and contribution to major birth defects in the population

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

A murine model of hereditary hemorrhagic telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGFbeta2 and TGFbeta3 have separate and sequential activities during epithelial-mesenchymal cell transformation in the embryonic heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Conditional inactivation of the TGF-beta type II receptor using Cre:Lox

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Coronary vessel development is dependent on the type III transforming growth factor beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor-beta induces loss of epithelial character and smooth muscle cell differentiation in epicardial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

A critical developmental role for tgfbr2 in myogenic cell lineages is revealed in mice expressing SM22-Cre, not SMMHC-Cre.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor beta-SMAD2 signaling and aortic arch development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Development of pharyngeal arch arteries in early mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

The incidence of congenital heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Causes and histopathology of ascending aortic disease in children and young adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Tgfbeta signaling is required for atrioventricular cushion mesenchyme remodeling during in vivo cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin expression in early development is associated with vasculogenesis and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Maternal rescue of transforming growth factor-beta 1 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Defective angiogenesis in mice lacking endoglin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGF-β signaling in aortic aneurysm: another round of controversy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Aneurysm syndromes caused by mutations in the TGF-beta receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin is required for myogenic differentiation potential of neural crest stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Expression patterns of Tgfbeta1-3 associate with myocardialisation of the outflow tract and the development of the epicardium and the fibrous heart skeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfbeta2 knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGFbeta1 and TGFbeta3 are partially redundant effectors in brain vascular morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor beta and mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Signaling by members of the TGF-beta family in vascular morphogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Transforming growth factor-beta 3 is required for secondary palate fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Coronary arteries form by developmental reprogramming of venous cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

The TGFβ type II receptor plays a critical role in the endothelial cells during cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGF-beta1 and angiotensin networking in cardiac remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Hereditary haemorrhagic telangiectasia: pathophysiology, diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Signaling via the Tgf-beta type I receptor Alk5 in heart development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Epistatic interactions between modifier genes confer strain-specific redundancy for Tgfb1 in developmental angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Extracellular control of TGFbeta signalling in vascular development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Formation of the coronary vasculature during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

The Loeys-Dietz syndrome: an update for the clinician

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Restricted expression of type-II TGF beta receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Tgf-beta superfamily signaling in embryonic development and homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Understanding the role of transforming growth factor-beta signalling in the heart: overview of studies using genetic mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

Non-Smad pathways in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBDRA.20794

21 January 2018

Identifiers

DOI

10.1002/BDRA.20794

1 reference

24 August 2017

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