(Q37889246)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

review article

1 reference

title

Histone deacetylase inhibition as an anticancer telomerase-targeting strategy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

author name string

Richard Grundy

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

8 August 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Cancer

4 February 2020

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

volume

129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

page(s)

2765-2774

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21671468%20AND%20SRC:MED&resulttype=core&format=json

Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells

4 February 2020

cites work

1 reference

Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.

21 January 2018

1 reference

Epigenomic profiling of cancer cells

21 January 2018

1 reference

Apoptosis: a link between cancer genetics and chemotherapy

21 January 2018

1 reference

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

21 January 2018

1 reference

HDACi--targets beyond chromatin.

21 January 2018

1 reference

Histone deacetylase inhibitors: overview and perspectives

21 January 2018

1 reference

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

Prospects: histone deacetylase inhibitors

21 January 2018

1 reference

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

21 January 2018

1 reference

Histone deacetylase inhibitors: insights into mechanisms of lethality

21 January 2018

1 reference

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

1 reference

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

21 January 2018

1 reference

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

21 January 2018

1 reference

Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway?

21 January 2018

1 reference

Experimental study on inhibitory effects of histone deacetylase inhibitor MS-275 and TSA on bladder cancer cells

21 January 2018

1 reference

Histone deacetylase inhibitors trichostatin A and valproic acid induce cell cycle arrest and p21 expression in immortalized human endometrial stromal cells

21 January 2018

1 reference

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo

21 January 2018

1 reference

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

21 January 2018

1 reference

Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells.

21 January 2018

1 reference

Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice

21 January 2018

1 reference

Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53.

21 January 2018

1 reference

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

21 January 2018

1 reference

Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma

21 January 2018

1 reference

Targeting histone deacetyalses in the treatment of B- and T-cell malignancies

21 January 2018

1 reference

Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

21 January 2018

1 reference

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

1 reference

Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

21 January 2018

1 reference

FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cells

21 January 2018

1 reference

Histone deacetylase inhibitors require caspase activity to induce apoptosis in lung and prostate carcinoma cells

21 January 2018

1 reference

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

21 January 2018

1 reference

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

21 January 2018

1 reference

ChIP-chip for genome-wide analysis of protein binding in mammalian cells

21 January 2018

1 reference

Telomerase maintains telomere structure in normal human cells.

21 January 2018

1 reference

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

1 reference

Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells

21 January 2018

1 reference

In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells.

21 January 2018

1 reference

Direct activation of TERT transcription by c-MYC.

21 January 2018

1 reference

Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells

21 January 2018

1 reference

On the road to immortality: hTERT upregulation in cancer cells

21 January 2018

1 reference

Function and regulation of the transcription factors of the Myc/Max/Mad network

21 January 2018

1 reference

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation

21 January 2018

1 reference

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells.

21 January 2018

1 reference

Induction of endogenous telomerase (hTERT) by c-Myc in WI-38 fibroblasts transformed with specific genetic elements

21 January 2018

1 reference

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

21 January 2018

1 reference

The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells

21 January 2018

1 reference

Hormones and growth factors regulate telomerase activity in ageing and cancer

21 January 2018

1 reference

Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene

21 January 2018

1 reference

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

21 January 2018

1 reference

c-myc is a downstream target of the Smad pathway

21 January 2018

1 reference

Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

21 January 2018

1 reference

Transforming growth factor-beta inhibits telomerase through SMAD3 and E2F transcription factors

21 January 2018

1 reference

Telomerase and cancer therapeutics

21 January 2018

1 reference

Telomeres and telomerase in normal and cancer stem cells

21 January 2018

1 reference

Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells.

21 January 2018

1 reference

Induction of apoptosis and inhibition of telomerase activity by trichostatin A, a histone deacetylase inhibitor, in human leukemic U937 cells

21 January 2018

1 reference

Reduction of telomerase activity in human liver cancer cells by a histone deacetylase inhibitor

21 January 2018

1 reference

Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor

21 January 2018

1 reference

Alternative lengthening of telomeres: models, mechanisms and implications

21 January 2018

1 reference

Histone deacetylase inhibition attenuates cell growth with associated telomerase inhibition in high-grade childhood brain tumor cells

21 January 2018

1 reference

Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1

21 January 2018

1 reference

Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells

21 January 2018

1 reference

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition

21 January 2018

1 reference

The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth

21 January 2018

1 reference

Telomerase downregulation in cancer brain stem cell

21 January 2018

1 reference

The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines

21 January 2018

1 reference

Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference

21 January 2018

1 reference

Characterization of chronic myeloid leukemia stem cells.

21 January 2018

1 reference

Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms

21 January 2018

1 reference

A new description of cellular quiescence

21 January 2018

1 reference

Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.

21 January 2018

1 reference

Generation of a functional mammary gland from a single stem cell

21 January 2018

1 reference

CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells.

21 January 2018

1 reference

Regulating the leukaemia stem cell

21 January 2018

1 reference

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

21 January 2018

1 reference

Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate

21 January 2018

1 reference

Histone deacetylase inhibitors in cancer therapy

21 January 2018

1 reference