(Q37889815)

24 August 2017

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title

Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease (English)

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24 August 2017

endoplasmic reticulum

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Tito Calì

1

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PubMed ID

21674642

24 August 2017

Denis Ottolini

series ordinal

2

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PubMed ID

21674642

24 August 2017

Marisa Brini

series ordinal

3

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24 August 2017

1 May 2011

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24 August 2017

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24 August 2017

37

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24 August 2017

3

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24 August 2017

228-240

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Mitochondrial Bioenergetics, Aging, and Aging-Related Disease

24 August 2017

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Ca(2+) signalling in mitochondria: mechanism and role in physiology and pathology.

21 January 2018

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Mitochondrial mutations in cancer

21 January 2018

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

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The changing shape of mitochondrial apoptosis

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

Parkinson's disease: mechanisms and models

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

21 January 2018

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Mitochondria take center stage in aging and neurodegeneration

21 January 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

21 January 2018

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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

21 January 2018

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Characterization of PINK1 processing, stability, and subcellular localization

21 January 2018

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Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.

21 January 2018

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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

21 January 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls

21 January 2018

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

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Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

21 January 2018

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Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

21 January 2018

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Mitochondrial localization of DJ-1 leads to enhanced neuroprotection

21 January 2018

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DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity

21 January 2018

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Mitochondrial association of alpha-synuclein causes oxidative stress

21 January 2018

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Retracted: DJ-1 Modulates α-Synuclein Aggregation State in a Cellular Model of Oxidative Stress: Relevance for Parkinson's Disease and Involvement of HSP70

21 January 2018

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Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

21 January 2018

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Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

21 January 2018

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Parkin affects mitochondrial function and apoptosis in neuronal and myogenic cells

21 January 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

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Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

21 January 2018

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The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

21 January 2018

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

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Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

21 January 2018

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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

21 January 2018

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

21 January 2018

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PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis

21 January 2018

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Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

21 January 2018

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Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

21 January 2018

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

21 January 2018

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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy

21 January 2018

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

21 January 2018

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Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy

21 January 2018

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Calcium signaling in neurons: molecular mechanisms and cellular consequences

21 January 2018

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Presynaptic Ca2+ dynamics, Ca2+ buffers and synaptic efficacy

21 January 2018

1 reference

NMDA and AMPA receptors: old channels, new tricks

21 January 2018

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Calcium pumps in health and disease

21 January 2018

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Ca2+ signals and neuronal death in brain ischemia

21 January 2018

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Calcium, ageing, and neuronal vulnerability in Parkinson's disease

21 January 2018

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Biomedicine. Parkinson's--divergent causes, convergent mechanisms.

21 January 2018

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Intracellular and extracellular electrophysiology of nigral dopaminergic neurons--2. Action potential generating mechanisms and morphological correlates.

21 January 2018

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Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases

21 January 2018

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Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K.

21 January 2018

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Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease.

21 January 2018

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'Rejuvenation' protects neurons in mouse models of Parkinson's disease

21 January 2018

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Common inflammatory mechanisms in Lewy body disease and Alzheimer disease

21 January 2018

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Possible involvement of Ca2+ signaling in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.

21 January 2018

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Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase

21 January 2018

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DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

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Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null mice

21 January 2018

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Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.

21 January 2018

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Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.

21 January 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells

21 January 2018

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Alpha-synuclein overexpression and aggregation exacerbates impairment of mitochondrial functions by augmenting oxidative stress in human neuroblastoma cells

21 January 2018

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alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells

21 January 2018

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Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux

21 January 2018

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

21 January 2018

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Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance

21 January 2018

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PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

21 January 2018

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Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice

21 January 2018

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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.

21 January 2018

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Pathways for protein disulphide bond formation

21 January 2018

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The endoplasmic reticulum crossroads for newly synthesized polypeptide chains

21 January 2018

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Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum.

21 January 2018

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ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

21 January 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

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Endoplasmic reticulum stress responses

21 January 2018

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress

21 January 2018

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Activation of the unfolded protein response in Parkinson's disease.

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

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Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

21 January 2018

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The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death

21 January 2018

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Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

21 January 2018

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Calcium signalling: dynamics, homeostasis and remodelling

21 January 2018

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Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.

21 January 2018

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Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: relevance to Parkinson's disease

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

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Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease

21 January 2018

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Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein

21 January 2018

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Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function

21 January 2018

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Microtubule depolymerization potentiates alpha-synuclein oligomerization

21 January 2018

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PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease

21 January 2018

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The ubiquitin pathway in Parkinson's disease.

21 January 2018

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

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Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants

21 January 2018

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Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

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Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

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Parkinson's disease: genetic versus toxin-induced rodent models

21 January 2018

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Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

21 January 2018

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PINK1 function in health and disease

21 January 2018

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.159

1 reference

24 August 2017

1 reference

PubMed ID

21674642