(Q37889961)

24 August 2017

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title

Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer (English)

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24 August 2017

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3

Lisa Pickering

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24 August 2017

Amy Guppy

1

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PubMed ID

21675836

24 August 2017

Mariam Jamal-Hanjani

series ordinal

2

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PubMed ID

21675836

24 August 2017

language of work or name

English

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publication date

1 June 2011

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24 August 2017

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24 August 2017

7

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24 August 2017

6

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24 August 2017

727-736

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Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

24 August 2017

1 reference

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer

21 January 2018

1 reference

Diabetes mellitus and breast cancer

21 January 2018

1 reference

Diabetes mellitus and risk of breast cancer: a meta-analysis

21 January 2018

1 reference

Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study.

21 January 2018

1 reference

High insulin levels in newly diagnosed breast cancer patients reflect underlying insulin resistance and are associated with components of the insulin resistance syndrome

21 January 2018

1 reference

Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; Internat

21 January 2018

1 reference

Metabolic syndrome, central obesity and insulin resistance are associated with adverse pathological features in postmenopausal breast cancer.

21 January 2018

1 reference

The association of metabolic syndrome with triple-negative breast cancer

21 January 2018

1 reference

Metabolic syndrome as a prognostic factor for breast cancer recurrences

21 January 2018

1 reference

Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor

21 January 2018

1 reference

Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy.

21 January 2018

1 reference

Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

21 January 2018

1 reference

Defining the pathway to insulin-like growth factor system targeting in cancer

21 January 2018

1 reference

The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer

21 January 2018

1 reference

Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors

21 January 2018

1 reference

Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study

21 January 2018

1 reference

Factors affecting sensitivity and specificity of screening mammography and MRI in women with an inherited risk for breast cancer

21 January 2018

1 reference

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin

21 January 2018

1 reference

Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

21 January 2018

1 reference

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

21 January 2018

1 reference

The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

21 January 2018

1 reference

Long-term metformin use is associated with decreased risk of breast cancer.

21 January 2018

1 reference

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

21 January 2018

1 reference

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

Very high risk of cancer in familial Peutz-Jeghers syndrome

21 January 2018

1 reference

Insulin-lowering effects of metformin in women with early breast cancer

21 January 2018

1 reference

Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer

21 January 2018

1 reference

AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation

21 January 2018

1 reference

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

21 January 2018

1 reference

Is it time to test metformin in breast cancer clinical trials?

21 January 2018

1 reference

The PIK3CA gene is mutated with high frequency in human breast cancers.

21 January 2018

1 reference

The role of autophagy in cancer development and response to therapy.

21 January 2018

1 reference

AMP-activated protein kinase and cancer

21 January 2018

1 reference

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

21 January 2018

1 reference

21 January 2018

1 reference

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

21 January 2018

1 reference

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

21 January 2018

1 reference

Insulin and insulin-like growth factor signalling in neoplasia

21 January 2018

1 reference

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

21 January 2018

1 reference

Metformin in chemically-induced mammary carcinogenesis in rats

21 January 2018

1 reference

Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERalpha negative MDA-MB-435 breast cancer model

21 January 2018

1 reference

Metformin induces unique biological and molecular responses in triple negative breast cancer cells

21 January 2018

1 reference

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

1 reference

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

21 January 2018

1 reference

The antidiabetic drug metformin: a pharmaceutical AMPK activator to overcome breast cancer resistance to HER2 inhibitors while decreasing risk of cardiomyopathy

21 January 2018

1 reference

mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb).

21 January 2018

1 reference

Regulation of survivin by ErbB2 signaling: therapeutic implications for ErbB2-overexpressing breast cancers

21 January 2018

1 reference

Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

21 January 2018

1 reference

Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells

21 January 2018

1 reference

Dietary energy availability affects primary and metastatic breast cancer and metformin efficacy

21 January 2018

1 reference

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

21 January 2018

1 reference

Incorporating the antidiabetic drug metformin in HER2-positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: an ongoing clinical-translational research experience at the Catalan Institute of Oncology.

21 January 2018

1 reference

Metformin, diet and breast cancer: an avenue for chemoprevention.

21 January 2018

1 reference

LKB1; linking cell structure and tumor suppression

21 January 2018

1 reference

Drug transporters and imatinib treatment: implications for clinical practice

21 January 2018

1 reference

Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene

21 January 2018

1 reference

Genetic polymorphisms in diabetes: influence on therapy with oral antidiabetics

21 January 2018

1 reference

Clearance of the high intestinal (18)F-FDG uptake associated with metformin after stopping the drug

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FON.11.49

1 reference

24 August 2017

1 reference

PubMed ID

21675836