(Q37897219)

25 August 2017

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title

Animal models of idiosyncratic drug-induced liver injury--current status (English)

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25 August 2017

Robert A Roth

1

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25 August 2017

Patricia E Ganey

series ordinal

2

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25 August 2017

language of work or name

English

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publication date

4 July 2011

1 reference

Critical Reviews in Toxicology

25 August 2017

published in

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25 August 2017

volume

41

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25 August 2017

issue

9

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25 August 2017

page(s)

723-739

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Drug-induced liver injury: insights from genetic studies.

25 August 2017

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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

21 January 2018

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Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction

21 January 2018

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The morphologic spectrum of halothane-induced hepatic injury: analysis of 77 cases.

21 January 2018

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Detection of antibodies to a halothane metabolite hapten in sera from patients with halothane-associated hepatitis

21 January 2018

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Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

21 January 2018

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Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

21 January 2018

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Halothane‐Induced Liver Damage: An Analysis of the Material Reported to the Swedish Adverse Drug Reaction Committee, 1966–1973

21 January 2018

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Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility

21 January 2018

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Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.

21 January 2018

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Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?

21 January 2018

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Circulating immune complexes in patients with fulminant hepatic failure

21 January 2018

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Effect of polyI:C cotreatment on halothane-induced liver injury in mice

21 January 2018

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Troglitazone and liver injury: in search of answers

21 January 2018

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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Effect of lipopolysaccharide (LPS)-evoked host defense activation on hepatic microsomal formation and reduction of sulfamethoxazole hydroxylamine in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models

21 January 2018

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Mechanisms of idiosyncratic drug reactions: the case of felbamate.

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.575765

A mouse model of severe halothane hepatitis based on human risk factors

21 January 2018

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

21 January 2018

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https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Subacute hepatic failure associated with a new antidiabetic agent, troglitazone: a case report with autopsy examination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Case-control exploration of relationships between early rash or liver toxicity and plasma concentrations of nevirapine and primary metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Mechanisms of liver injury. III. Role of glutathione redox status in liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Inflammatory mediators of hepatic steatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Current concepts of biliary secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Role of hepatic metabolism in the bioactivation and detoxication of amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic drug hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Hepatocanalicular injury associated with vitamin A derivative etretinate. An idiosyncratic hypersensitivity reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Toxicity of valproic acid in mice with decreased plasma and tissue carnitine stores

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Troglitazone-induced hepatic mitochondrial proteome expression dynamics in heterozygous Sod2(+/-) mice: two-stage oxidative injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Carnitine in the treatment of valproic acid-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

A review of the common properties of drugs with idiosyncratic hepatotoxicity and the "multiple determinant hypothesis" for the manifestation of idiosyncratic drug toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and the kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Use of sandwich-cultured hepatocytes to evaluate impaired bile acid transport as a mechanism of drug-induced hepatotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Correlation between specific immunity to a metabolite of halothane and hepatic lesions after multiple exposures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Tissue repair: an important determinant of final outcome of toxicant-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Post-halothane jaundice in relation to previous administration of halothane.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Halothane hepatitis: attempt to develop an animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

The role of metabolic activation in drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Study of the sequence of events involved in nevirapine-induced skin rash in Brown Norway rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

An evaluation of the toxicities of 2'-fluorouridine and 2'-fluorocytidine-HCl in F344 rats and woodchucks (Marmota monax).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Hepatic disposition of electrophilic acyl glucuronide conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Aromatic antiepileptic drugs and mitochondrial toxicity: effects on mitochondria isolated from rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Animal models of idiosyncratic drug reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Protein targets of reactive electrophiles in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Pattern recognition receptors and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

The metabolism of diclofenac--enzymology and toxicology perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Drug metabolite profiling and elucidation of drug-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Potentiation of isoniazid-induced liver toxicity by rifampicin in a combinational therapy of antitubercular drugs (rifampicin, isoniazid and pyrazinamide) in Wistar rats: A toxicity profile study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Mitochondrial permeability transition as a source of superoxide anion induced by the nitroaromatic drug nimesulide in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic drug reactions: current understanding

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic drug reactions: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic toxicity: a convergence of risk factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Role of cytochromes P450 in drug metabolism and hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Idiosyncratic liver injury: challenges and approaches.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Role of neutrophils in a mouse model of halothane-induced liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Separation and detection methods for covalent drug-protein adducts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2011.575765

10.3109/10408444.2011.575765

21 January 2018

Identifiers

DOI

1 reference

25 August 2017

1 reference