(Q37912205)

25 August 2017

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title

Proteomics revisits the cancer metabolome (English)

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25 August 2017

Hao Hu

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Cao Deng

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Cao Deng

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author name string

Tao Yang

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25 August 2017

Qiang Dong

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25 August 2017

Ya Chen

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25 August 2017

Edouard C Nice

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25 August 2017

Canhua Huang

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25 August 2017

Yuquan Wei

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25 August 2017

1 August 2011

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Expert Review of Proteomics

25 August 2017

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25 August 2017

8

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25 August 2017

4

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25 August 2017

505-533

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On the Origin of Cancer Cells

25 August 2017

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The metabolic switch and its regulation in cancer cells.

21 January 2018

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

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Energy metabolism in tumor cells

21 January 2018

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21 January 2018

Surfing the p53 network

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Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation

21 January 2018

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Brick by brick: metabolism and tumor cell growth

21 January 2018

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Revisiting the Warburg effect in cancer cells with proteomics. The emergence of new approaches to diagnosis, prognosis and therapy.

21 January 2018

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De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

21 January 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

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Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis

21 January 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

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Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway

21 January 2018

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Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma

21 January 2018

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Proteomic profiling identifies aberrant epigenetic modifications induced by hepatitis B virus X protein

21 January 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

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Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1.

21 January 2018

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Beginnings of a signal-transduction pathway for bioenergetic control of cell survival

21 January 2018

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Cancer cell metabolism: Warburg and beyond

21 January 2018

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Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells

21 January 2018

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Inherited, non-spherocytic haemolysis due to deficiency of glucose-6-phosphate dehydrogenase

21 January 2018

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Tumor-specific positron emission tomography imaging in patients: [18F] fluorodeoxyglucose and beyond

21 January 2018

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Glucose transporters in the 21st Century

21 January 2018

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Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond

21 January 2018

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Glucose metabolism in cancer. Evidence that demethylation events play a role in activating type II hexokinase gene expression

21 January 2018

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Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

21 January 2018

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Mitochondrial gateways to cancer

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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Isoenzyme shift from glucokinase to hexokinase is not an early but a late event in hepatocarcinogenesis

21 January 2018

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An unusual high-Km hexokinase is expressed in the mhAT3F hepatoma cell line

21 January 2018

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High aerobic glycolysis of rat hepatoma cells in culture: Role of mitochondrial hexokinase

21 January 2018

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Regulation of cellular metabolism by protein lysine acetylation

21 January 2018

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

21 January 2018

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Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism.

21 January 2018

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Grade-dependent proteomics characterization of kidney cancer

21 January 2018

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Phosphorylation of the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase/PFKFB3 family of glycolytic regulators in human cancer

21 January 2018

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The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase

21 January 2018

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Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma

21 January 2018

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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling

21 January 2018

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Identification of potential genes/proteins regulated by Tiam1 in colorectal cancer by microarray analysis and proteome analysis

21 January 2018

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Purification and identification of monoubiquitin-phosphoglycerate mutase B complex from human colorectal cancer tissues

21 January 2018

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Protein profiles associated with survival in lung adenocarcinoma

21 January 2018

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Proteome analysis of human lung squamous carcinoma

21 January 2018

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Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase B in human prostate cancer cells: two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometry evalu

21 January 2018

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Identification of differentially expressed, tumor-associated proteins in oral squamous cell carcinoma by proteomic analysis

21 January 2018

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Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas

21 January 2018

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Diverse proteomic alterations in gastric adenocarcinoma.

21 January 2018

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Proteomic analysis of hyperoxia-induced responses in the human choriocarcinoma cell line JEG-3.

21 January 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

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Tumor metabolism: hnRNP proteins get in on the act

21 January 2018

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Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

21 January 2018

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Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

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Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

21 January 2018

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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

21 January 2018

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

21 January 2018

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Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway

21 January 2018

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 January 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 January 2018

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Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

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Multiple molecular forms of lactate dehydrogenase and glucose 6-phosphate dehydrogenase in normal and abnormal human breast tissues

21 January 2018

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Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

21 January 2018

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Lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer

21 January 2018

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iTRAQ-facilitated proteomic analysis of human prostate cancer cells identifies proteins associated with progression.

21 January 2018

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p32 (C1QBP) and cancer cell metabolism: is the Warburg effect a lot of hot air?

21 January 2018

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Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines

21 January 2018

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Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer.

21 January 2018

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p53 regulates mitochondrial respiration

21 January 2018

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The role of p53 in glucose metabolism

21 January 2018

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

21 January 2018

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IDH1 and IDH2 mutations in gliomas

21 January 2018

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The Warburg hypothesis fifty years later

21 January 2018

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Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin

21 January 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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Tumor suppressors and cell metabolism: a recipe for cancer growth

21 January 2018

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Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

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The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy

21 January 2018

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Biochemistry. A glucose-to-gene link

21 January 2018

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The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

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An emerging role of mTOR in lipid biosynthesis.

21 January 2018

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MYC, microRNAs and glutamine addiction in cancers

21 January 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

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Detection of transient protein-protein interactions by bimolecular fluorescence complementation: the Abl-SH3 case.

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism

21 January 2018

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Current affairs in quantitative targeted proteomics: multiple reaction monitoring-mass spectrometry

21 January 2018

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Targeted proteomic analysis of 14-3-3sigma in nasopharyngeal carcinoma

21 January 2018

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Loss of 14-3-3sigma in prostate cancer and its precursors

21 January 2018

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14-3-3sigma in endometrial cancer--a possible prognostic marker in early-stage cancer

21 January 2018

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Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins.

21 January 2018

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14-3-3 proteins--an update

21 January 2018

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Cyclin G2 regulates adipogenesis through PPAR gamma coactivation

21 January 2018

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Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity.

21 January 2018

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PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells

21 January 2018

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Biology of PPAR gamma in cancer: a critical review on existing lacunae

21 January 2018

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Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis

21 January 2018

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Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

21 January 2018

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Cyclin G2 dysregulation in human oral cancer

21 January 2018

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Proteomics. Integrating interactomes

21 January 2018

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Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor

21 January 2018

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

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Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets

21 January 2018

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Critical role for hypothalamic mTOR activity in energy balance

21 January 2018

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

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The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

21 January 2018

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The coordinate regulation of the p53 and mTOR pathways in cells

21 January 2018

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Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

21 January 2018

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

21 January 2018

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Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer

21 January 2018

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

21 January 2018

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Proteomics, pathway array and signaling network-based medicine in cancer

21 January 2018

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Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cells

21 January 2018

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Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.

21 January 2018

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Role of Wnt/β-catenin signaling in liver metabolism and cancer

21 January 2018

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Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplification

21 January 2018

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Profiling bladder cancer using targeted antibody arrays

21 January 2018

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Use of multidimensional separation protocols for the purification of trace components in complex biological samples for proteomics analysis

21 January 2018

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The discovery and validation of colorectal cancer biomarkers

21 January 2018

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Targeted proteomic analysis of glycolysis in cancer cells

21 January 2018

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Functional proteomics to dissect tyrosine kinase signalling pathways in cancer

21 January 2018

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Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

21 January 2018

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Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry

21 January 2018

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A systematic approach to the analysis of protein phosphorylation

21 January 2018

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Quantitative proteomic approaches for studying phosphotyrosine signaling.

21 January 2018

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Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection

21 January 2018

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Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents

21 January 2018

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Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells

21 January 2018

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Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases

21 January 2018

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Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

21 January 2018

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Lung cancer: intragenic ERBB2 kinase mutations in tumours

21 January 2018

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Acetylation and chromosomal functions.

21 January 2018

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Re-SET-ting heterochromatin by histone methyltransferases

21 January 2018

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HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention

21 January 2018

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Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

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Metabolomics technology and bioinformatics

21 January 2018

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¹H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice.

21 January 2018

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Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover

21 January 2018

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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

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Analysis of the adult human plasma metabolome

21 January 2018

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Molecular concepts analysis links tumors, pathways, mechanisms, and drugs

21 January 2018

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Integrative molecular concept modeling of prostate cancer progression.

21 January 2018

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Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

21 January 2018

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The rate-limiting step for tumor [18F]fluoro-2-deoxy-D-glucose (FDG) incorporation

21 January 2018

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Systems biology: its practice and challenges

21 January 2018

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Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells

21 January 2018

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Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited

21 January 2018

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Lipotoxicity: when tissues overeat

21 January 2018

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Application of metabolic flux analysis to identify the mechanisms of free fatty acid toxicity to human hepatoma cell line

21 January 2018

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[1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats

21 January 2018

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Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

21 January 2018

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Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma

21 January 2018

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Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution.

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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Metabolic profiles of cancer cells

21 January 2018

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Predicting aberrant CpG island methylation

21 January 2018

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Genomic microarrays in human genetic disease and cancer

21 January 2018

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A comparison of analog and Next-Generation transcriptomic tools for mammalian studies.

21 January 2018

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Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

21 January 2018

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A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

21 January 2018

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A comparison of selected mRNA and protein abundances in human liver

21 January 2018

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21 January 2018

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Lysine acetylation: codified crosstalk with other posttranslational modifications

21 January 2018

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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

21 January 2018

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Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2.

21 January 2018

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The ubiquitin-proteasome pathway and its role in cancer

21 January 2018

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Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays

21 January 2018

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Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

21 January 2018

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Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.

21 January 2018

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Integrated molecular profiling of SOD2 expression in multiple myeloma

21 January 2018

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Integrative oncoproteomics strategies for anticancer drug discovery

21 January 2018

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A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism

21 January 2018

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Pathway analysis of kidney cancer using proteomics and metabolic profiling

21 January 2018

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Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling.

21 January 2018

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Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer

21 January 2018

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Proteomic analysis distinguishes basaloid carcinoma as a distinct subtype of nonsmall cell lung carcinoma.

21 January 2018

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Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis: novel protein markers in hepatocellular carcinoma tissues

21 January 2018

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Quantitative proteomics study of breast cancer cell lines isolated from a single patient: discovery of TIMM17A as a marker for breast cancer

21 January 2018

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Discovery of putative pancreatic cancer biomarkers using subcellular proteomics.

21 January 2018

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Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer

21 January 2018

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Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis

21 January 2018

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Phosphorylation of Pyruvate Kinase and Glycolytic Metabolism in Three Human Glioma Cell Lines

21 January 2018

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Functional and quantitative proteomics using SILAC

21 January 2018

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Signaling Networks in Gastric Cancer Cells Revealed by Phosphoproteomics

21 January 2018

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Selective Isolation at the Femtomole Level of Phosphopeptides from Proteolytic Digests Using 2D-NanoLC-ESI-MS/MS and Titanium Oxide Precolumns

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/EPR.11.31

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25 August 2017

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