(Q37736257)

22 August 2017

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title

Phosphoinositide signalling in cancer: beyond PI3K and PTEN. (English)

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22 August 2017

Tom D Bunney

1

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PubMed ID

20414202

22 August 2017

Matilda Katan

series ordinal

2

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PubMed ID

20414202

22 August 2017

language of work or name

English

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publication date

1 May 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

5

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22 August 2017

342-352

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https://scigraph.springernature.com/pub.10.1038/nrc2842

22 August 2017

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High frequency of mutations of the PIK3CA gene in human cancers

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

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Oncogenic mutations of PIK3CA in human cancers

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

31 March 2020

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Portrait of PTEN: messages from mutant mice.

31 March 2020

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31 March 2020

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PTEN: its deregulation and tumorigenesis.

31 March 2020

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31 March 2020

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31 March 2020

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Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover.

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

31 March 2020

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In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling

31 March 2020

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Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling

31 March 2020

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Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer

31 March 2020

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A molecular signature of metastasis in primary solid tumors

31 March 2020

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Gene expression profiling predicts clinical outcome of breast cancer

31 March 2020

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The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation.

31 March 2020

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Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death

31 March 2020

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

31 March 2020

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Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene.

31 March 2020

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High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization

31 March 2020

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Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer

31 March 2020

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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers.

31 March 2020

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Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

31 March 2020

1 reference

Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.

31 March 2020

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A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family.

31 March 2020

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PIP(2) and proteins: interactions, organization, and information flow

31 March 2020

1 reference

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

31 March 2020

1 reference

Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases

31 March 2020

1 reference

Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

31 March 2020

1 reference

Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions

31 March 2020

1 reference

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

31 March 2020

1 reference

31 March 2020

1 reference

Making and breaking contacts: the cellular biology of cadherin regulation

31 March 2020

1 reference

Molecular architecture and functional model of the endocytic AP2 complex

31 March 2020

1 reference

Type I gamma phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with mu 1B adaptin

31 March 2020

1 reference

Phosphatidylinositol-4-phosphate 5-kinase gamma is associated with cell-cell junction in A431 epithelial cells

31 March 2020

1 reference

PIP5KI gamma is required for cardiovascular and neuronal development

31 March 2020

1 reference

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

31 March 2020

1 reference

E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer

31 March 2020

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The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion.

31 March 2020

1 reference

Cell polarity in development and cancer.

31 March 2020

1 reference

Structural and mechanistic aspects of phospholipase Cgamma regulation

31 March 2020

1 reference

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

31 March 2020

1 reference

Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin.

31 March 2020

1 reference

The cofilin pathway in breast cancer invasion and metastasis

31 March 2020

1 reference

Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells

31 March 2020

1 reference

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

31 March 2020

1 reference

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

31 March 2020

1 reference

Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering

31 March 2020

1 reference

Mapping the Phosphoinositide-Binding Site on Chick Cofilin Explains How PIP2 Regulates the Cofilin-Actin Interaction

31 March 2020

1 reference

Cofilin promotes actin polymerization and defines the direction of cell motility

31 March 2020

1 reference

Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis

31 March 2020

1 reference

Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration

31 March 2020

1 reference

PLCgamma1 is essential for early events in integrin signalling required for cell motility

31 March 2020

1 reference

Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.

31 March 2020

1 reference

Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

31 March 2020

1 reference

Elevated content of phospholipase C-gamma 1 in colorectal cancer tissues.

31 March 2020

1 reference

Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas

31 March 2020

1 reference

Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines.

31 March 2020

1 reference

PLC gamma contributes to metastasis of in situ-occurring mammary and prostate tumors

31 March 2020

1 reference

Phospholipase Cgamma1 is required for metastasis development and progression

31 March 2020

1 reference

Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry

31 March 2020

1 reference

Characterization of phospholipase C gamma enzymes with gain-of-function mutations

31 March 2020

1 reference

ErbB receptors and signaling pathways in cancer

31 March 2020

1 reference

Phospholipase C epsilon: linking second messengers and small GTPases

31 March 2020

1 reference

Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development

31 March 2020

1 reference

Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester

31 March 2020

1 reference

31 March 2020

Inflammation and cancer

1 reference

Phospholipase Cepsilon promotes intestinal tumorigenesis of Apc(Min/+) mice through augmentation of inflammation and angiogenesis.

31 March 2020

1 reference

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

31 March 2020

1 reference

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

31 March 2020

1 reference

Focus on myeloproliferative diseases and myelodysplastic syndromes

31 March 2020

1 reference

Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.

31 March 2020

1 reference

The regulation of cell motility and chemotaxis by phospholipid signaling

31 March 2020

1 reference

Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis.

31 March 2020

1 reference

12 December 2020

Epidermal growth factor receptor-stimulated activation of phospholipase Cgamma-1 promotes invasion of head and neck squamous cell carcinoma

1 reference

12 December 2020

Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables

1 reference

12 December 2020

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns

1 reference

12 December 2020

Expression profiling and subtype-specific expression of stomach cancer.

1 reference

12 December 2020

Type II PtdInsP kinases: location, regulation and function

1 reference

12 December 2020

Structure, function, and biology of SHIP proteins

1 reference

12 December 2020

SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells.

1 reference

12 December 2020

Mutation analysis of SHIP gene in acute leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2842

1 reference

22 August 2017

1 reference

PubMed ID

20414202