(Q40509159)

English

Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle

scientific article published on November 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

author name string

S Horn

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

E Endl

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

M M Weck

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

G W Mayr

5

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

M Jücker

6

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

publication date

1 November 2004

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

1839-1849

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

The phosphoinositide 3-kinase pathway

1 reference

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21 January 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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21 January 2018

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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21 January 2018

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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21 January 2018

The akt kinase: molecular determinants of oncogenicity

1 reference

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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21 January 2018

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

1 reference

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21 January 2018

SHIP, a new player in cytokine-induced signalling

1 reference

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21 January 2018

The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro.

1 reference

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21 January 2018

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

1 reference

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21 January 2018

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

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21 January 2018

BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis

1 reference

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21 January 2018

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia

1 reference

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Characterization of EBV-genome negative “null” and “T” cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma

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21 January 2018

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

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21 January 2018

Distinct classes of factor-independent mutants can be isolated after retroviral mutagenesis of a human myeloid stem cell line

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21 January 2018

The expression of Ki-67, MCM3, and p27 defines distinct subsets of proliferating, resting, and differentiated cells.

1 reference

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21 January 2018

Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase.

1 reference

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21 January 2018

The two SH2-domain-containing inositol 5-phosphatases SHIP1 and SHIP2 are coexpressed in human T lymphocytes

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

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21 January 2018

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

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21 January 2018

The Ki-67 protein: from the known and the unknown

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21 January 2018

Inhibitors of mammalian G1 cyclin-dependent kinases

1 reference

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

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21 January 2018

BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

1 reference

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21 January 2018

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

1 reference

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21 January 2018

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity

1 reference

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

1 reference

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21 January 2018

Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB.

1 reference

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21 January 2018

The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis

1 reference

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21 January 2018

Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors

1 reference

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21 January 2018

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?

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21 January 2018

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

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PI3K: downstream AKTion blocks apoptosis

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The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphatase

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PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 reference

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

1 reference

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

1 reference

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1 reference

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Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

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Effects of overexpression of the SH2-containing inositol phosphatase SHIP on proliferation and apoptosis of erythroid AS-E2 cells

1 reference

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

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An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403529

7 January 2021

based on heuristic

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10.1038/SJ.LEU.2403529

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Europe PubMed Central

PubMed publication ID

21 September 2017

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24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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