(Q37270444)

19 August 2017

1 reference

title

Understanding PTEN regulation: PIP2, polarity and protein stability (English)

1 reference

19 August 2017

N R Leslie

1

1 reference

19 August 2017

I H Batty

2

1 reference

19 August 2017

H Maccario

3

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19 August 2017

L Davidson

4

1 reference

19 August 2017

C P Downes

5

1 reference

19 August 2017

language of work or name

English

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publication date

1 September 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

41

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19 August 2017

5464-5476

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2008.243

19 August 2017

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cites work

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The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases

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PTEN enters the nuclear age.

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Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells

31 March 2020

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The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin

31 March 2020

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PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning

31 March 2020

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Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate

31 March 2020

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PTEN couples Sema3A signalling to growth cone collapse.

31 March 2020

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Feedback signaling controls leading-edge formation during chemotaxis

31 March 2020

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17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats

31 March 2020

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Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

31 March 2020

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Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor.

31 March 2020

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Membrane-binding and activation mechanism of PTEN.

31 March 2020

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The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration

31 March 2020

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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

31 March 2020

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DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

31 March 2020

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Metabolic switching of PI3K-dependent lipid signals

31 March 2020

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The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2.

31 March 2020

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Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting.

31 March 2020

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Leading-edge research: PtdIns(3,4,5)P3 and directed migration.

31 March 2020

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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

31 March 2020

1 reference

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Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

SHIP2 overexpression strongly reduces the proliferation rate of K562 erythroleukemia cell line

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Signaling networks assembled by oncogenic EGFR and c-Met

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Imaging antigen-induced PI3K activation in T cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.243

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Navigating through models of chemotaxis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Temporal and spatial regulation of chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Identification and characterization of a novel inositol polyphosphate 5-phosphatase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Chemotaxis in Dictyostelium: how to walk straight using parallel pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphoinositide signaling plays a key role in cytokinesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Anti-apoptotic action of (2S,3S,4R)-N"-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylatio

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phospholipase C regulation of phosphatidylinositol 3,4,5-trisphosphate-mediated chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Purification of ARAP3 and characterization of GAP activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN regulates motility but not directionality during leukocyte chemotaxis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Lipid phosphatases as drug discovery targets for type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Reversible inactivation of the tumor suppressor PTEN by H2O2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The redox regulation of PI 3-kinase-dependent signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN function: how normal cells control it and tumour cells lose it

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulation of PTEN by Rho small GTPases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN enters the nucleus by diffusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN is destabilized by phosphorylation on Thr366.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The role of phosphatases in inositol signaling reactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

AKT/PKB signaling: navigating downstream

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Direct identification of PTEN phosphorylation sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The Isolation and Characterization of cDNA Encoding Human and Rat Brain Inositol Polyphosphate 4-Phosphatase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Casein kinase Iepsilon down-regulates phospho-Akt via PTEN, following genotoxic stress-induced apoptosis in hematopoietic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PCAF modulates PTEN activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

G protein signaling events are activated at the leading edge of chemotactic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN phosphatase selectively binds phosphoinositides and undergoes structural changes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN as an effector in the signaling of antimigratory G protein-coupled receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The role of phosphoinositides in membrane transport

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Portrait of PTEN: messages from mutant mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Ubiquitination regulates PTEN nuclear import and tumor suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Phosphorylation of the PTEN tail regulates protein stability and function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Cell polarity in development and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

PDZ domains of Par-3 as potential phosphoinositide signaling integrators

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Membrane phosphatidylserine regulates surface charge and protein localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Lipid signaling and the modulation of surface charge during phagocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Receptor activation alters inner surface potential during phagocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

Redox regulation of PTEN by S-nitrosothiols

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.243

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/ONC.2008.243

1 reference

19 August 2017

1 reference