(Q37934215)

25 August 2017

1 reference

title

The tumor suppressor kinase LKB1: lessons from mouse models (English)

1 reference

25 August 2017

2

1 reference

25 August 2017

Saara Ollila

1

1 reference

25 August 2017

publication date

15 September 2011

1 reference

Journal of Molecular Cell Biology

25 August 2017

published in

1 reference

25 August 2017

volume

3

1 reference

25 August 2017

issue

6

1 reference

25 August 2017

page(s)

330-340

1 reference

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

SADB phosphorylation of gamma-tubulin regulates centrosome duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Inactivation of Apc in the mouse prostate causes prostate carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Peutz-Jeghers syndrome and management recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 regulates pancreatic beta cell size, polarity, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Management of cellular energy by the AMP-activated protein kinase system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1; linking cell structure and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Mammalian SAD kinases are required for neuronal polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Prevalence and specificity of LKB1 genetic alterations in lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Cancer risks in LKB1 germline mutation carriers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 deficiency in Tie2-Cre-expressing cells impairs ischemia-induced angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 deficiency causes prostate neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Hallmarks of cancer: interactions with the tumor stroma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1/STRAD promotes axon initiation during neuronal polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Pten in stromal fibroblasts suppresses mammary epithelial tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Impaired gastric gland differentiation in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Molecular mechanisms of tumor suppression by LKB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Lkb1 is required for TGFbeta-mediated myofibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Somatic LKB1 mutations promote cervical cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

High-resolution 19p13.2-13.3 allelotyping of breast carcinomas demonstrates frequent loss of heterozygosity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJMCB%2FMJR016

21 January 2018

Identifiers

DOI

10.1093/JMCB/MJR016

1 reference

25 August 2017

1 reference