(Q37939947)

25 August 2017

1 reference

title

PDZ domains: the building blocks regulating tumorigenesis (English)

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25 August 2017

author name string

Vanitha Krishna Subbaiah

1

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25 August 2017

Christian Kranjec

2

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25 August 2017

Miranda Thomas

3

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25 August 2017

Lawrence Banks

4

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25 August 2017

language of work or name

English

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publication date

1 October 2011

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25 August 2017

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25 August 2017

volume

439

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25 August 2017

issue

2

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25 August 2017

page(s)

195-205

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PDZ domains: targeting signalling molecules to sub-membranous sites

25 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Evidence for PDZ domains in bacteria, yeast, and plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Mammalian Scribble forms a tight complex with the betaPIX exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Crystal structure of a PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Structures of a human papillomavirus (HPV) E6 polypeptide bound to MAGUK proteins: mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Recognition of unique carboxyl-terminal motifs by distinct PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Dimerization of the scaffolding protein ZO-1 through the second PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Domain-swapped dimerization of ZO-1 PDZ2 generates specific and regulatory connexin43-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PDZ domains bind carboxy-terminal sequences of target proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Peptide recognition by PTB and PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

A specificity map for the PDZ domain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Differential regulation of human papillomavirus E6 by protein kinase A: conditional degradation of human discs large protein by oncogenic E6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Cell polarity proteins: common targets for tumorigenic human viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Human papillomaviruses, cervical cancer and cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Aberrant overexpression of the cell polarity module scribble in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Human and primate tumour viruses use PDZ binding as an evolutionarily conserved mechanism of targeting cell polarity regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Par complex in cancer: a regulator of normal cell polarity joins the dark side

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Epithelial-mesenchymal transitions in tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Dishevelled: The hub of Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Mechanism of activation of the Formin protein Daam1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Identification of a specific inhibitor of the dishevelled PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Lessons from hereditary colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Tenets of PTEN tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTEN: The down side of PI 3-kinase signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTEN/MMAC1 expression in melanoma resection specimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

NHERF1/EBP50 is a new marker in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

NHERF (Na+/H+ exchanger regulatory factor) gene mutations in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Protein tyrosine phosphatases in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Mutational analysis of the tyrosine phosphatome in colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The pathways to tumor suppression via route p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Regulation of c-Src by binding to the PDZ domain of AF-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

c-Src and cooperating partners in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Coupling membrane protrusion and cell adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Rho GTPases control polarity, protrusion, and adhesion during cell movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Catching a GEF by its tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Bcr-Abl variants: biological and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Proteins regulating Ras and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

CADM1/TSLC1 inactivation by promoter hypermethylation is a frequent event in colorectal carcinogenesis and correlates with late stages of the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Tumor suppressor in lung cancer (TSLC)1 suppresses epithelial cell scattering and tubulogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Expression and regulatory role of GAIP-interacting protein GIPC in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

A PDZ domain protein interacts with the C-terminal tail of the insulin-like growth factor-1 receptor but not with the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Genome-wide analysis of PDZ domain binding reveals inherent functional overlap within the PDZ interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

Random mutagenesis of PDZOmi domain and selection of mutants that specifically bind the Myc proto-oncogene and induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20110903

21 January 2018

Identifiers

DOI

10.1042/BJ20110903

1 reference

25 August 2017

1 reference