(Q37942050)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

review article

1 reference

title

The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Roger Preston

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

Eimear M Gleeson

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

publication date

4 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

14 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

69

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

717-726

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00018-011-0825-0

14 February 2020

exact match

0 references

cites work

Inflammation and thrombosis

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

How the protease thrombin talks to cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Human vascular smooth muscle cells express functionally active endothelial cell protein C receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Expression and function of the endothelial protein C receptor in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Characterization of protein C receptor expression in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial protein C receptor is expressed in rat cortical and hippocampal neurons and is necessary for protective effect of activated protein C at glutamate excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Organization and chromosomal localization of the human endothelial protein C receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The crystal structure of the endothelial protein C receptor and a bound phospholipid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Multifunctional specificity of the protein C/activated protein C Gla domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Binding of factor VIIa to the endothelial cell protein C receptor reduces its coagulant activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Recent advances in processing and presentation of CD1 bound lipid antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial cell protein C receptor plays an important role in protein C activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The endothelial cells downregulate the generation of factor VIIa through EPCR binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Extraembryonic expression of EPCR is essential for embryonic viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Identification of functional endothelial protein C receptor in human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Metalloproteolytic release of endothelial cell protein C receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Soluble endothelial protein C receptor levels in healthy population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

The functional properties of a truncated form of endothelial cell protein C receptor generated by alternative splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Modulation of monocyte function by activated protein C, a natural anticoagulant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Caveolae are required for protease-selective signaling by protease-activated receptor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Thrombin and activated protein C inhibit the expression of secretory group IIA phospholipase A(2) in the TNF-alpha-activated endothelial cells by EPCR and PAR-1 dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Thrombin down-regulates the TGF-beta-mediated synthesis of collagen and fibronectin by human proximal tubule epithelial cells through the EPCR-dependent activation of PAR-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial cell protein C receptor cellular localization and trafficking: potential functional implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Autoantibodies against the endothelial receptor of protein C are associated with acute myocardial infarction in young women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Cytoprotective protein C pathways and implications for stroke and neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C prevents glutamate- and thrombin-induced activation of nuclear factor-kappaB in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Functional recovery after embolic stroke in rodents by activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Role of activated protein C and its receptor in inhibition of tumor metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0825-0

Activated protein C protects against myocardial ischemic/reperfusion injury through AMP-activated protein kinase signaling

21 January 2018

1 reference

12 December 2020

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

1 reference

12 December 2020

A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse

1 reference

12 December 2020

The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis

1 reference

12 December 2020

Mice with a severe deficiency of the endothelial protein C receptor gene develop, survive, and reproduce normally, and do not present with enhanced arterial thrombosis after challenge

1 reference

12 December 2020

Thrombin upregulates the angiopoietin-Tie2 Axis: endothelial protein C receptor occupancy prevents the thrombin mobilization of angiopoietin 2 and P-selectin from Weibel-Palade bodies

1 reference

12 December 2020

The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors

1 reference

12 December 2020

A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function

1 reference

12 December 2020

Factor X and factor VII binding to endothelial protein C receptor differs between species

1 reference

12 December 2020

Protection of vascular barrier integrity by activated protein C in murine models depends on protease-activated receptor-1.

1 reference

12 December 2020

Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes

1 reference

12 December 2020

Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C

1 reference

12 December 2020

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1 reference

12 December 2020

Autoantibodies against endothelial protein C receptor and the risk of a first deep vein thrombosis

1 reference

12 December 2020

Protease activated receptor 1 (PAR-1) activation by thrombin is protective in human pulmonary artery endothelial cells if endothelial protein C receptor is occupied by its natural ligand.

1 reference

12 December 2020

Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo

1 reference

12 December 2020

Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domains

1 reference

12 December 2020

Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C.

1 reference

12 December 2020

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

1 reference

12 December 2020

Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines.

1 reference

12 December 2020

Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development

1 reference

12 December 2020

The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor

1 reference

12 December 2020

Protease-activated receptors and platelet function

1 reference

12 December 2020

10.1007/S00018-011-0825-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21968919%20AND%20SRC:MED&resulttype=core&format=json

release_frh4jl3osrbnzar4l2eqh6meka

14 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/frh4jl3osrbnzar4l2eqh6meka

24 November 2022

mapped directly with Wikidata item

1 reference