(Q37947994)

25 August 2017

It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival (English)

1 reference

25 August 2017

1 reference

Douglas R Green

2

0 references

author name string

Andrew Oberst

series ordinal

1

1 reference

25 August 2017

21 October 2011

1 reference

Nature Reviews Molecular Cell Biology

25 August 2017

1 reference

25 August 2017

12

1 reference

25 August 2017

11

1 reference

25 August 2017

757-763

1 reference

https://scigraph.springernature.com/pub.10.1038/nrm3214

25 August 2017

0 references

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Caspase 8 inhibits programmed necrosis by processing CYLD

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Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

6 September 2017

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

6 September 2017

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Linear ubiquitination prevents inflammation and regulates immune signalling

6 September 2017

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Mechanisms of necroptosis in T cells

6 September 2017

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Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

6 September 2017

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

6 September 2017

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Functional complementation between FADD and RIP1 in embryos and lymphocytes

6 September 2017

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TNFR1-induced activation of the classical NF-κB pathway

6 September 2017

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Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation

6 September 2017

1 reference

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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

6 September 2017

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

6 September 2017

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

6 September 2017

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

6 September 2017

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RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

6 September 2017

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Human caspases: activation, specificity, and regulation

6 September 2017

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Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

6 September 2017

1 reference

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Mechanism of procaspase-8 activation by c-FLIPL

6 September 2017

1 reference

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Death receptor signal transducers: nodes of coordination in immune signaling networks

6 September 2017

1 reference

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

6 September 2017

1 reference

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A role for cFLIP in B cell proliferation and stress MAPK regulation

6 September 2017

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Antigen-mediated T cell expansion regulated by parallel pathways of death

6 September 2017

1 reference

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

6 September 2017

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TNF-alpha induces two distinct caspase-8 activation pathways

6 September 2017

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Identification of RIP1 kinase as a specific cellular target of necrostatins

6 September 2017

1 reference

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Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation.

6 September 2017

1 reference

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Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

6 September 2017

1 reference

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The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

An essential role for c-FLIP in the efficient development of mature T lymphocytes

6 September 2017

1 reference

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Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

6 September 2017

1 reference

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Activation of caspases-8 and -10 by FLIP(L).

6 September 2017

1 reference

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

6 September 2017

1 reference

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

A unified model for apical caspase activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

A requirement for CARMA1 in TCR-induced NF-kappa B activation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Activation of NF-kappaB by FADD, Casper, and caspase-8.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Inhibition of death receptor signals by cellular FLIP

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

NF-kappaB signals induce the expression of c-FLIP.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Virus inhibition of RIP3-dependent necrosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Proapoptotic signalling through Toll-like receptor-3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Differential requirement for caspase 9 in apoptotic pathways in vivo.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

RIP1 comes back to life as a cell death regulator in TNFR1 signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FADD deficiency impairs early hematopoiesis in the bone marrow

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Role of proteolysis in caspase-8 activation and stabilization

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Cutting edge: innate immunity conferred by B cells is regulated by caspase-8.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

Conditional Fas-associated death domain protein (FADD): GFP knockout mice reveal FADD is dispensable in thymic development but essential in peripheral T cell homeostasis

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

FADD-deficient T cells exhibit a disaccord in regulation of the cell cycle machinery

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3627210

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

1 September 2018

1 reference

Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling

21 January 2018

1 reference

Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection

31 March 2020

1 reference

Role of caspase-8 in hepatocyte response to infection and injury in mice

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM3214

1 reference

25 August 2017

1 reference

PMC publication ID

3627210

25 August 2017

PubMed publication ID

22016059

1 reference

PMC publication ID

3627210