(Q37951560)

25 August 2017

title

Structural and biophysical determinants of αβ T-cell antigen recognition (English)

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25 August 2017

3

John J Miles

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25 August 2017

David K Cole

5

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Andrew K Sewell

object named as

Andrew K Sewell

series ordinal

2

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David A Price

object named as

David A Price

series ordinal

4

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author name string

John S Bridgeman

series ordinal

1

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25 August 2017

publication date

1 January 2012

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25 August 2017

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25 August 2017

volume

135

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25 August 2017

issue

1

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25 August 2017

page(s)

9-18

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Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands

25 August 2017

cites work

1 reference

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21 January 2018

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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

21 January 2018

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

21 January 2018

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CD8beta endows CD8 with efficient coreceptor function by coupling T cell receptor/CD3 to raft-associated CD8/p56(lck) complexes

21 January 2018

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CD8 kinetically promotes ligand binding to the T-cell antigen receptor.

21 January 2018

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Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

21 January 2018

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How TCRs bind MHCs, peptides, and coreceptors

21 January 2018

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The specificity of TCR/pMHC interaction

21 January 2018

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Positive selection of thymocytes

21 January 2018

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Molecular interactions mediating T cell antigen recognition

21 January 2018

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How a single T cell receptor recognizes both self and foreign MHC

21 January 2018

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Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

21 January 2018

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T cell allorecognition via molecular mimicry

21 January 2018

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Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

21 January 2018

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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination

21 January 2018

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Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The molecular basis of TCR germline bias for MHC is surprisingly simple

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structural basis of T cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Specificity and degeneracy of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

A comprehensive calorimetric investigation of an entropically driven T cell receptor-peptide/major histocompatibility complex interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Human TCR-binding affinity is governed by MHC class restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Human T cell responses against melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Cancer immunotherapy: moving beyond current vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

High-affinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Kinetic proofreading in T-cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Directed evolution of human T-cell receptors with picomolar affinities by phage display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Human T cells expressing affinity-matured TCR display accelerated responses but fail to recognize low density of MHC-peptide antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Conformational Melding Permits a Conserved Binding Geometry in TCR Recognition of Foreign and Self Molecular Mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The shaping of T cell receptor recognition by self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Allelic polymorphism in the T cell receptor and its impact on immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T cell cross-reactivity and conformational changes during TCR engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Kinetic discrimination in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

A kinetic window constricts the T cell receptor repertoire in the thymus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The impact of TCR-binding properties and antigen presentation format on T cell responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Fast on-rates allow short dwell time ligands to activate T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Mechanisms for T cell receptor triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Permissive geometry model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The structure and ligand interactions of CD2: implications for T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.

21 January 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246648

Lack of strict correlation of functional sensitization with the apparent affinity of MHC/peptide complexes for the TCR.

16 September 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3246648

Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

16 September 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2011.03515.X

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

21 January 2018

1 reference

12 December 2020

Activated TCRs remain marked for internalization after dissociation from pMHC

1 reference

12 December 2020

Two different T cell receptors use different thermodynamic strategies to recognize the same peptide/MHC ligand

1 reference

12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 December 2020

TCR binding to peptide-MHC stabilizes a flexible recognition interface

1 reference

12 December 2020

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate

1 reference

12 December 2020

Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes

1 reference

12 December 2020

10.1111/J.1365-2567.2011.03515.X

Identifiers

DOI

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25 August 2017

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