(Q37956115)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

The multifactorial role of leptin in driving the breast cancer microenvironment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

author name string

Sebastiano Andò

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

publication date

15 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Endocrinology

16 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

page(s)

263-275

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22083089%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrendo.2011.184

16 January 2020

exact match

0 references

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Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization

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21 January 2018

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Hormonal regulation of mammary differentiation and milk secretion

21 January 2018

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Leptin signaling in breast cancer: An overview

21 January 2018

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Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival

21 January 2018

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21 January 2018

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Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development

21 January 2018

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Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin

21 January 2018

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leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3

21 January 2018

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Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line

21 January 2018

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Differential effects of leptin on cancer in vitro

21 January 2018

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Leptin mediates a proliferative response in human MCF7 breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Susceptibility of lean and obese Zucker rats to tumorigenesis induced by N-methyl-N-nitrosourea

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Genetically obese MMTV-TGF-alpha/Lep(ob)Lep(ob) female mice do not develop mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Effects of high-fat diet and/or body weight on mammary tumor leptin and apoptosis signaling pathways in MMTV-TGF-alpha mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Diet-induced obesity and mammary tumor development in MMTV-neu female mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin receptor signaling supports cancer cell metabolism through suppression of mitochondrial respiration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

STAT3 revs up the powerhouse

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Function of mitochondrial Stat3 in cellular respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Akt-dependent transformation: there is more to growth than just surviving

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin upregulates VEGF in breast cancer via canonic and non-canonical signalling pathways and NFkappaB/HIF-1alpha activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Biological action of leptin as an angiogenic factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin, the product of Ob gene, promotes angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Tumour-cell invasion and migration: diversity and escape mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Cellular hypoxia and adipose tissue dysfunction in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Regulation of angiogenesis by hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Insulin-dependent leptin expression in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Human leptin stimulates proliferation and activation of human circulating monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin indirectly activates human neutrophils via induction of TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin and mTOR: partners in metabolism and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Nutrient sensing and metabolic decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Inflammatory mechanisms in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Regulatory T cells in obesity: the leptin connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Estrogen carcinogenesis in breast cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Differential expression and regulation of leptin receptor isoforms in the rat brain: effects of fasting and oestrogen.

21 January 2018

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Direct in vitro effects of androgens and estrogens on ob gene expression and leptin secretion in human adipose tissue

21 January 2018

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Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell Line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin receptor 5'untranslated regions in the rat: relative abundance, genomic organization and relation to putative response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Total body aromatization in postmenopausal breast cancer patients is strongly correlated to plasma leptin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Subcellular localization of cyclic AMP-responsive element binding protein-regulated transcription coactivator 2 provides a link between obesity and breast cancer in postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Estrogen regulates expression of tumor necrosis factor receptors in breast adipose fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Development of leptin antagonists and their potential use in experimental biology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin as a potential therapeutic target for breast cancer prevention and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Subcloning, expression, purification, and characterization of recombinant human leptin-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Development of a pharmacologically improved peptide agonist of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.

21 January 2018

1 reference

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Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Competitive inhibition of leptin signaling results in amelioration of liver fibrosis through modulation of stellate cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Development and characterization of high affinity leptins and leptin antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Molecular mechanisms of leptin and adiponectin in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Serum adiponectin and leptin levels in Taiwanese breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mammary tumor development from T47-D human breast cancer cells in obese ovariectomized mice with and without estradiol supplements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Arterial elasticity and plasma levels of adiponectin and leptin in type 2 diabetic patients treated with thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Cohort study of pioglitazone and cancer incidence in patients with diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Thiazolidinediones: an update.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

AMP-activated protein kinase--the fat controller of the energy railroad

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

The tumour microenvironment--introduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

The rapidly expanding family of adipokines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: reciprocal involvement of PKC-alpha and PPAR expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Effect of high fat diet on body weight and mammary tumor latency in MMTV-TGF-alpha mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Glycolysis inhibition by 2-deoxy-D-glucose reverts the metastatic phenotype in vitro and in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Regulation of vascular smooth muscle cell migration and proliferation in vitro and in injured rat arteries by a synthetic matrix metalloproteinase inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mitogen-activated protein kinases mediate matrix metalloproteinase-9 expression in vascular smooth muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Hypoxia-Inducible Factor-1 (HIF-1)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

31 March 2020

12 December 2020

Leucine in food mediates some of the postprandial rise in plasma leptin concentrations

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Comparison of R128Q mutations in human, ovine, and chicken leptins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Effects of chronic vs. intermittent calorie restriction on mammary tumor incidence and serum adiponectin and leptin levels in MMTV-TGF-α mice at different ages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2011.184

Tissue leptin levels in patients with breast cancer.

31 March 2020

1 reference

12 December 2020

Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status

1 reference

12 December 2020

Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients

1 reference

12 December 2020

Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis

1 reference

12 December 2020

Leptin regulation of aromatase activity in adipose stromal cells from regularly cycling women.

1 reference

12 December 2020

Regulation of estrogen receptors alpha and beta in human breast carcinoma by exogenous leptin in nude mouse xenograft model.

1 reference

12 December 2020

Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma:

1 reference

12 December 2020

Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients.

1 reference

12 December 2020

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

1 reference

12 December 2020

Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters.

1 reference

12 December 2020

Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice

1 reference

12 December 2020

Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma.

1 reference

12 December 2020