(Q37956536)

25 August 2017

title

Modulating toll-like receptor 7 and 9 responses as therapy for allergy and autoimmunity (English)

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25 August 2017

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Damir Matesic

1

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25 August 2017

Aleksander Lenert

series ordinal

2

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25 August 2017

Petar Lenert

series ordinal

3

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25 August 2017

publication date

1 February 2012

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Current Allergy and Asthma Reports

25 August 2017

published in

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25 August 2017

volume

12

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25 August 2017

issue

1

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25 August 2017

page(s)

8-17

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DNA-based immunotherapeutics for the treatment of allergic disease.

25 August 2017

cites work

1 reference

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Allergen-immunostimulatory oligodeoxynucleotide conjugate: a novel allergoid for immunotherapy

21 January 2018

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Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity

21 January 2018

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TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor 7 function is reduced in adolescents with asthma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Secretory leukocyte protease inhibitor plays an important role in the regulation of allergic asthma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Use of CpG oligonucleotides in treatment of asthma and allergic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB x NZWF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor-7 modulates immune complex glomerulonephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

An etiopathogenic role for the type I IFN system in SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor driven B cell activation in the induction of systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Nucleic acid sensing Toll-like receptors in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

A mammalian tRNAHis-Containing antigen is recognized by the polymyosits-specific antibody antijo-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

TLR-9 activation of marginal zone B cells in lupus mice regulates immunity through increased IL-10 production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor 9 signaling protects against murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Apoptosis and systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

G-rich DNA suppresses systemic lupus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Treatment with a toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Inhibition of murine macrophage IL-12 production by natural and synthetic DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Sequence requirements for oligodeoxyribonucleotide inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Structural requirements and applications of inhibitory oligodeoxyribonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The molecular basis for the lack of immunostimulatory activity of vertebrate DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

DNA motifs suppressing TLR9 responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Effect of suppressive oligodeoxynucleotides on the development of inflammation-induced papillomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Aggregation and secondary loop structure of oligonucleotides do not determine their ability to inhibit TLR9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

B-cell receptor for antigen modulates B-cell responses to complex TLR9 agonists and antagonists: implications for systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

B cells do not take up bacterial DNA: an essential role for antigen in exposure of DNA to toll-like receptor-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T-rich phosphorothiate oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Oligodeoxynucleotides differentially modulate activation of TLR7 and TLR8 by imidazoquinolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Engagement of the B cell receptor for antigen differentially affects B cell responses to Toll-like receptor-7 agonists and antagonists in BXSB mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-011-0233-4

In vitro inhibition of murine IFN gamma production by phosphorothioate deoxyguanosine oligomers

21 January 2018

1 reference

12 December 2020

Mucosal immunotherapy with CpG oligodeoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure

1 reference

12 December 2020

Toll-like receptor 7-triggered immune response in the lung mediates acute and long-lasting suppression of experimental asthma

1 reference

12 December 2020

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

1 reference

12 December 2020

Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds.

1 reference

12 December 2020

Immunomodulatory effects of CpG oligodeoxynucleotides on established th2 responses

1 reference

12 December 2020

Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice

1 reference

12 December 2020

Nucleosomes are exposed at the cell surface in apoptosis.

1 reference

12 December 2020

CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma☆☆☆★

1 reference

12 December 2020

Treatment of established asthma in a murine model using CpG oligodeoxynucleotides

1 reference

12 December 2020

Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma

1 reference

12 December 2020

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus

1 reference

12 December 2020

Toll-like receptor 9 activation with CpG oligodeoxynucleotides for asthma therapy

1 reference

12 December 2020

CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma

1 reference

12 December 2020

TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways

1 reference

12 December 2020

TLR8 deficiency leads to autoimmunity in mice

1 reference

12 December 2020

The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma

1 reference

12 December 2020

Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus

1 reference

12 December 2020

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

1 reference

12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

12 December 2020

Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9.

1 reference

12 December 2020

The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid

1 reference

12 December 2020

Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells

1 reference

12 December 2020

Structural characterization of the inhibitory DNA motif for the type A (D)-CpG-induced cytokine secretion and NK-cell lytic activity in mouse spleen cells

1 reference

12 December 2020

Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen bindin

1 reference

12 December 2020

Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus

1 reference

12 December 2020

Immunomodulatory effects of viral TLR ligands on experimental asthma depend on the additive effects of IL-12 and IL-10

1 reference

12 December 2020

Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides

1 reference

12 December 2020

10.1007/S11882-011-0233-4

Identifiers

DOI

1 reference

25 August 2017

1 reference