(Q37959387)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22106024%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Targeting tumor hypoxia in nasopharyngeal carcinoma (English)

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17 January 2020

0 references

2

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17 January 2020

Anthony Tak-Cheung Chan

5

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17 January 2020

author name string

Bo Hong

1

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17 January 2020

Masumi Hashiguchi

3

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17 January 2020

Edwin Pun Hui

4

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17 January 2020

publication date

22 November 2011

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17 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22106024%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

35

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17 January 2020

issue

1

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17 January 2020

page(s)

133-145

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Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments

17 January 2020

cites work

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State-of-the-art management of nasopharyngeal carcinoma: current and future directions

21 January 2018

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21 January 2018

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Phase III study comparing standard radiotherapy with or without weekly oxaliplatin in treatment of locoregionally advanced nasopharyngeal carcinoma: preliminary results

21 January 2018

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The activity of mTOR inhibitor RAD001 (everolimus) in nasopharyngeal carcinoma and cisplatin-resistant cell lines

21 January 2018

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A small molecule inhibitor of NF-kappaB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells

21 January 2018

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Inhibitors of epidermoid growth factor receptor suppress cell growth and enhance chemosensitivity of nasopharyngeal cancer cells in vitro

21 January 2018

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Anti-invasion, anti-proliferation and anoikis-sensitization activities of lapatinib in nasopharyngeal carcinoma cells.

21 January 2018

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Preclinical evaluation of sunitinib as single agent or in combination with chemotherapy in nasopharyngeal carcinoma.

21 January 2018

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Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.

21 January 2018

1 reference

Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase.

21 January 2018

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Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma.

21 January 2018

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Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma.

21 January 2018

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A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy.

21 January 2018

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Systemic approach to improving treatment outcome in nasopharyngeal carcinoma: current and future directions.

21 January 2018

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Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma.

21 January 2018

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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck

21 January 2018

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Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

21 January 2018

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Hypoxia in head and neck cancer: how much, how important?

21 January 2018

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Tumor microenvironment and the response to anticancer therapy

21 January 2018

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Aberrant vascular architecture in tumors and its importance in drug-based therapies

21 January 2018

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Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

21 January 2018

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Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis

21 January 2018

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Oxygenation predicts radiation response and survival in patients with cervix cancer

21 January 2018

1 reference

Tumor hypoxia imaging with [F-18] fluoromisonidazole positron emission tomography in head and neck cancer

21 January 2018

1 reference

Plasma osteopontin, hypoxia, and response to radiotherapy in nasopharyngeal cancer.

21 January 2018

1 reference

Hypoxia inducible factor-1 alpha and vascular endothelial growth factor expression are associated with a poor prognosis in patients with nasopharyngeal carcinoma receiving radiotherapy with carbogen and nicotinamide

21 January 2018

1 reference

Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma

21 January 2018

1 reference

Genome-wide expression analysis using microarray identified complex signaling pathways modulated by hypoxia in nasopharyngeal carcinoma.

21 January 2018

1 reference

The Epstein-Barr virus: a group 1 carcinogen?

21 January 2018

1 reference

Association of immunoescape mechanisms with Epstein-Barr virus infection in nasopharyngeal carcinoma

21 January 2018

1 reference

STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro.

21 January 2018

1 reference

EBV latent membrane protein 1 up-regulates hypoxia-inducible factor 1alpha through Siah1-mediated down-regulation of prolyl hydroxylases 1 and 3 in nasopharyngeal epithelial cells

21 January 2018

1 reference

Epstein-Barr virus latent membrane protein 1 induces synthesis of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro

21 January 2018

1 reference

Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.

21 January 2018

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression, implicated in survival, differently in different carcinoma cell lines.

21 January 2018

1 reference

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

21 January 2018

1 reference

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation

21 January 2018

1 reference

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

21 January 2018

1 reference

Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models

21 January 2018

1 reference

The endothelin axis: emerging role in cancer

21 January 2018

1 reference

Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.

21 January 2018

1 reference

Tumor hypoxia and cancer progression.

21 January 2018

1 reference

Gadd45a and Gadd45b protect hematopoietic cells from UV-induced apoptosis via distinct signaling pathways, including p38 activation and JNK inhibition.

21 January 2018

1 reference

Effect of hypoxia on gene expression by human hepatocytes (HepG2).

21 January 2018

1 reference

Investigating hypoxic tumor physiology through gene expression patterns

21 January 2018

1 reference

Hypoxia-induced autophagy: cell death or cell survival?

21 January 2018

1 reference

Hypoxia signalling in cancer and approaches to enforce tumour regression

21 January 2018

1 reference

21 January 2018

1 reference

BNIP3 protects HepG2 cells against etoposide-induced cell death under hypoxia by an autophagy-independent pathway

21 January 2018

1 reference

Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis

21 January 2018

1 reference

Expression and modification of ARC (apoptosis repressor with a CARD domain) is distinctly regulated by oxidative stress in cancer cells

21 January 2018

1 reference

Lysyl oxidase mediates hypoxic control of metastasis

21 January 2018

1 reference

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

21 January 2018

1 reference

Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion

21 January 2018

1 reference

Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines.

21 January 2018

1 reference

Co-expression of urokinase, urokinase receptor and PAI-1 is necessary for optimum invasiveness of cultured lung cancer cells

21 January 2018

1 reference

Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro

21 January 2018

1 reference

Prognostic value of plasminogen activator inhibitor-1 in head and neck squamous cell carcinoma

21 January 2018

1 reference

Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness

21 January 2018

1 reference

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer

21 January 2018

1 reference

Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8.

21 January 2018

1 reference

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

21 January 2018

1 reference

MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia

21 January 2018

1 reference

Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion

21 January 2018

1 reference

Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.

21 January 2018

1 reference

Endostar, a recombined humanized endostatin, enhances the radioresponse for human nasopharyngeal carcinoma and human lung adenocarcinoma xenografts in mice

21 January 2018

1 reference

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

Acidic pH enhances the invasive behavior of human melanoma cells

21 January 2018

1 reference

Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells.

21 January 2018

1 reference

Mammalian stanniocalcins and cancer

21 January 2018

1 reference

Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).

21 January 2018

1 reference

Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group

21 January 2018

1 reference

Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003.

21 January 2018

1 reference

ARCON: experience in 215 patients with advanced head-and-neck cancer.

21 January 2018

1 reference

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells

21 January 2018

1 reference

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

21 January 2018

1 reference

How to overcome (and exploit) tumor hypoxia for targeted gene therapy.

21 January 2018

1 reference

Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure

21 January 2018

1 reference

Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers.

21 January 2018

1 reference

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

21 January 2018

1 reference

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

21 January 2018

1 reference

Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading

21 January 2018

1 reference

Anticancer mechanisms of YC-1 in human lung cancer cell line, NCI-H226.

21 January 2018

1 reference

A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway

21 January 2018

1 reference

Identification of a novel small molecule HIF-1alpha translation inhibitor

21 January 2018

1 reference

Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study

21 January 2018

1 reference

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition

21 January 2018

1 reference

Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion

21 January 2018

1 reference

Targeting gene expression to hypoxic tumor cells

21 January 2018

1 reference

Clinical significance of measuring levels of tumor necrosis factor-alpha and soluble interleukin-2 receptor in nasopharyngeal carcinoma

21 January 2018

1 reference

21 January 2018

Nasopharyngeal carcinoma

1 reference

7 January 2021

Activation of signal transducer and activator of transcription 5 in human prostate cancer is associated with high histological grade

1 reference

7 January 2021

Nasopharyngeal carcinoma: modes of presentation

1 reference

7 January 2021

Overall Survival After Concurrent Cisplatin-Radiotherapy Compared With Radiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma

1 reference

7 January 2021

Fluorine-18 fluoromisonidazole tumour to muscle retention ratio for the detection of hypoxia in nasopharyngeal carcinoma

1 reference

7 January 2021

Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck

1 reference

7 January 2021

A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy

1 reference

7 January 2021

Elevated plasma big ET-1 is associated with distant failure in patients with advanced-stage nasopharyngeal carcinoma

1 reference

7 January 2021

Cyclooxygenase-2 expression in advanced nasopharyngeal carcinoma--a prognostic evaluation and correlation with hypoxia inducible factor 1alpha and vascular endothelial growth factor

1 reference

7 January 2021

Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

1 reference

7 January 2021

Photodynamic therapy in oncology

1 reference

7 January 2021

Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells

1 reference

7 January 2021

Plasminogen activator inhibitor-1 is an independent poor prognostic factor for survival in advanced stage epithelial ovarian cancer patients

1 reference

7 January 2021

Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: A report of the international CATAPULT I study group. Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors.

1 reference

7 January 2021

Tirapazamine with cisplatin in patients with advanced non-small-cell lung cancer: a phase II study

1 reference

7 January 2021

Regulation of hypoxia-induced mRNA expressions of HIF-1alpha and osteopontin and in vitro radiosensitization by tirapazamine in human nasopharyngeal carcinoma HNE-1 and CNE-1 cells.

1 reference

7 January 2021

Identifiers

DOI

10.1002/HED.21877

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22106024%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference