(Q37961786)

26 August 2017

title

Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells (English)

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26 August 2017

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Lee H Wong

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publication date

1 October 2010

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26 August 2017

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26 August 2017

volume

2

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26 August 2017

issue

5

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26 August 2017

page(s)

639-655

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

26 August 2017

cites work

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The DNA structures at the ends of eukaryotic chromosomes

21 January 2018

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Normal human chromosomes have long G-rich telomeric overhangs at one end

21 January 2018

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Mammalian telomeres end in a large duplex loop

21 January 2018

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Telomeres do D-loop-T-loop

21 January 2018

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Mammalian telomeres and telomerase

21 January 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity

21 January 2018

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Protein composition of catalytically active human telomerase from immortal cells

21 January 2018

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A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

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Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

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The RNA component of human telomerase

21 January 2018

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Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10

21 January 2018

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In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs

21 January 2018

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Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase

21 January 2018

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21 January 2018

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The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita

21 January 2018

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

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Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres.

21 January 2018

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Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

21 January 2018

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Impaired germinal center reaction in mice with short telomeres.

21 January 2018

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Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube

21 January 2018

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Effects of telomerase and telomere length on epidermal stem cell behavior

21 January 2018

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Syndromes of telomere shortening

21 January 2018

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A spectrum of severe familial liver disorders associate with telomerase mutations

21 January 2018

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Telomere maintenance and human bone marrow failure

21 January 2018

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The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

21 January 2018

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Telomere dynamics and telomerase activity in in vitro immortalised human cells.

21 January 2018

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Telomere maintenance by recombination in human cells.

21 January 2018

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Alternative lengthening of telomeres in mammalian cells

21 January 2018

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Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops

21 January 2018

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Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines

21 January 2018

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Recombination at long mutant telomeres produces tiny single- and double-stranded telomeric circles

21 January 2018

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Effects of reconstitution of telomerase activity on telomere maintenance by the alternative lengthening of telomeres (ALT) pathway

21 January 2018

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Telomere length maintenance--an ALTernative mechanism.

21 January 2018

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

21 January 2018

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Visualizing telomere dynamics in living mammalian cells using PNA probes

21 January 2018

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Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins

21 January 2018

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Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres

21 January 2018

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TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

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Shelterin: the protein complex that shapes and safeguards human telomeres

21 January 2018

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Pot1, the putative telomere end-binding protein in fission yeast and humans

21 January 2018

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Control of telomere length by the human telomeric protein TRF1

21 January 2018

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Control of human telomere length by TRF1 and TRF2

21 January 2018

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

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TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

21 January 2018

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

21 January 2018

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21 January 2018

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Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping

21 January 2018

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Senescence Induced by Altered Telomere State, Not Telomere Loss

21 January 2018

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T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

21 January 2018

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POT1 as a terminal transducer of TRF1 telomere length control

21 January 2018

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Loss of hPot1 function leads to telomere instability and a cut-like phenotype

21 January 2018

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POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

21 January 2018

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Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres

21 January 2018

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Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

21 January 2018

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Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

21 January 2018

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TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex

21 January 2018

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TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres

21 January 2018

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Telomere protection by mammalian Pot1 requires interaction with Tpp1

21 January 2018

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Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins

21 January 2018

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PTOP interacts with POT1 and regulates its localization to telomeres

21 January 2018

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The POT1-TPP1 telomere complex is a telomerase processivity factor

21 January 2018

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Identification of human Rap1: implications for telomere evolution

21 January 2018

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The human Rap1 protein complex and modulation of telomere length

21 January 2018

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Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

21 January 2018

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Replication and protection of telomeres

21 January 2018

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

21 January 2018

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Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

21 January 2018

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Nuclear structure in normal and Bloom syndrome cells

21 January 2018

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Telomere dysfunction as a cause of genomic instability in Werner syndrome

21 January 2018

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Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

21 January 2018

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Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

21 January 2018

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

21 January 2018

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

21 January 2018

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

21 January 2018

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The many faces of histone lysine methylation

21 January 2018

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

21 January 2018

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Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly

21 January 2018

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Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

21 January 2018

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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

21 January 2018

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Role of Rb family in the epigenetic definition of chromatin.

21 January 2018

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Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase

21 January 2018

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Role for the silencing protein Dot1 in meiotic checkpoint control

21 January 2018

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The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure

21 January 2018

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Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

21 January 2018

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 January 2018

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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases

21 January 2018

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Epigenetic regulation of telomeres in human cancer.

21 January 2018

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Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

21 January 2018

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Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

21 January 2018

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TERRA: telomeric repeat-containing RNA

21 January 2018

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Telomeres: the silence is broken

21 January 2018

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TERRA, CpG methylation and telomere heterochromatin: lessons from ICF syndrome cells

21 January 2018

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The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway

21 January 2018

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COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression

21 January 2018

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MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription

21 January 2018

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Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

21 January 2018

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TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres

21 January 2018

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Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice

21 January 2018

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Telomere maintenance in telomerase-deficient mouse embryonic stem cells: characterization of an amplified telomeric DNA

21 January 2018

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Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells.

21 January 2018

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Role of TRF2 in the assembly of telomeric chromatin.

21 January 2018

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Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells.

21 January 2018

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Chromatin in pluripotent embryonic stem cells and differentiation

21 January 2018

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Chromatin signatures of pluripotent cell lines

21 January 2018

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Unraveling epigenetic regulation in embryonic stem cells

21 January 2018

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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Induced pluripotency of mouse and human somatic cells

21 January 2018

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Telomeres and human disease: ageing, cancer and beyond

21 January 2018

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Telomere length, stem cells and aging

21 January 2018

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Telomere and telomerase in stem cells

21 January 2018

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Conditional telomerase induction causes proliferation of hair follicle stem cells

21 January 2018

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The longest telomeres: a general signature of adult stem cell compartments

21 January 2018

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Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres

21 January 2018

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Telomere lengthening early in development

21 January 2018

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Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells

21 January 2018

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Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells

21 January 2018

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Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX

21 January 2018

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Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1.

21 January 2018

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Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

21 January 2018

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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

21 January 2018

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The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

21 January 2018

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ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

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Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

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Mice cloned from embryonic stem cells

21 January 2018

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Extension of cell life-span and telomere length in animals cloned from senescent somatic cells

21 January 2018

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Normal telomere lengths found in cloned cattle

21 January 2018

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Analysis of telomere lengths in cloned sheep

21 January 2018

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Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

21 January 2018

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

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Inactivation of a human kinetochore by specific targeting of chromatin modifiers

21 January 2018

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

21 January 2018

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Tankyrase promotes telomere elongation in human cells

21 January 2018

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DNA methyltransferases control telomere length and telomere recombination in mammalian cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.10.49

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26 August 2017

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