(Q37961788)

26 August 2017

title

Role of epigenetics in Alzheimer's and Parkinson's disease (English)

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26 August 2017

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John B J Kwok

1

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26 August 2017

publication date

1 October 2010

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26 August 2017

number of pages

12

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based on heuristic

inferred from page(s)

published in

Epigenomics

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26 August 2017

volume

2

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26 August 2017

issue

5

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26 August 2017

page(s)

671-682

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The genetic epidemiology of neurodegenerative disease

26 August 2017

cites work

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Neuropathological stageing of Alzheimer-related changes

21 January 2018

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Amyloid precursor protein trafficking, processing, and function

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

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Presenilins and the gamma-secretase: still a complex problem

21 January 2018

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The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

21 January 2018

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Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

21 January 2018

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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

21 January 2018

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Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

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Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease

21 January 2018

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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Cerebral response to patient's own name in the vegetative and minimally conscious states

21 January 2018

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

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The ubiquitin pathway in Parkinson's disease

21 January 2018

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Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease

21 January 2018

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Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

21 January 2018

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The role of apolipoprotein E in Alzheimer's disease

21 January 2018

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Role of tau protein in both physiological and pathological conditions.

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Association of an extended haplotype in the tau gene with progressive supranuclear palsy

21 January 2018

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

21 January 2018

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Tau gene and Parkinson's disease: a case-control study and meta-analysis

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Tau haplotypes regulate transcription and are associated with Parkinson's disease.

21 January 2018

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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Exploiting the proteome to improve the genome-wide genetic analysis of epistasis in common human diseases

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease

21 January 2018

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GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

21 January 2018

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Glycogen synthase kinase-3 beta and tau genes interact in Parkinson's and Alzheimer's diseases.

21 January 2018

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Association between glycogen synthase kinase-3beta genetic polymorphism and late-onset Alzheimer's disease.

21 January 2018

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RNA regulation of epigenetic processes

21 January 2018

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Mechanisms of epigenetic inheritance

21 January 2018

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Chromatin modifications and their function

21 January 2018

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Genetic and environmental factors in cancer and neurodegenerative diseases

21 January 2018

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Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

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Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease

21 January 2018

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The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells.

21 January 2018

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Age-specific epigenetic drift in late-onset Alzheimer's disease

21 January 2018

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DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.

21 January 2018

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Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

21 January 2018

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Pooled analysis of tobacco use and risk of Parkinson disease

21 January 2018

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Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin.

21 January 2018

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Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation

21 January 2018

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The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood

21 January 2018

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Environmental risk factors for Parkinson's disease and parkinsonism: the Geoparkinson study

21 January 2018

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The environment, epigenetics and amyloidogenesis

21 January 2018

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Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

21 January 2018

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The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.

21 January 2018

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Past adult lead exposure is linked to neurodegeneration measured by brain MRI

21 January 2018

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Epigenetic alteration by the chemical substances, food and environmental factors.

21 January 2018

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Folate: a functional food constituent

21 January 2018

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Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine

21 January 2018

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One-carbon metabolism and Alzheimer's disease: focus on epigenetics

21 January 2018

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S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production.

21 January 2018

1 reference

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice

21 January 2018

1 reference

Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine

21 January 2018

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B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A.

21 January 2018

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Pharmacogenetic relevance of MTHFR polymorphisms

21 January 2018

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Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease

21 January 2018

1 reference

Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation

21 January 2018

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DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism

21 January 2018

1 reference

Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation

21 January 2018

1 reference

An epigenetic perspective on the free radical theory of development

21 January 2018

1 reference

Epigenetics, oxidative stress, and Alzheimer disease

21 January 2018

1 reference

Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells

21 January 2018

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Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration

21 January 2018

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Allelic skewing of DNA methylation is widespread across the genome

21 January 2018

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Genetic control of individual differences in gene-specific methylation in human brain.

21 January 2018

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Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury

21 January 2018

1 reference

A randomized trial comparing defined-duration with continuous irinotecan until disease progression in fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer

21 January 2018

1 reference

Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

21 January 2018

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Targeting protein aggregation in neurodegeneration--lessons from polyglutamine disorders

21 January 2018

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Recovery of learning and memory is associated with chromatin remodelling

21 January 2018

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Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

21 January 2018

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FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspension

21 January 2018

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FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma

21 January 2018

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Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines

21 January 2018

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HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

21 January 2018

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Folate intake and colorectal cancer risk: a meta-analytical approach

21 January 2018

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Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma

21 January 2018

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Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia.

21 January 2018

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High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial

21 January 2018

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A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status.

21 January 2018

1 reference

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/EPI.10.43

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26 August 2017

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