(Q40223933)

18 September 2017

Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation (English)

1 reference

18 September 2017

4

1 reference

18 September 2017

Sampath Ramachandiran

1

1 reference

18 September 2017

Jason M Hansen

2

1 reference

18 September 2017

Dean P Jones

3

1 reference

18 September 2017

Gary W Miller

5

1 reference

18 September 2017

3 October 2006

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18 September 2017

Toxicological Sciences

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18 September 2017

95

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18 September 2017

163-171

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18 September 2017

1

1 reference

Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells

18 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Toxin-induced models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Thioredoxin: friend or foe in human disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Activation of nuclear factor-kappa b transcriptional activity in airway epithelial cells by thioredoxin but not by N-acetyl-cysteine and glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Neuronal activity-dependent cell survival mediated by transcription factor MEF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

The role of c-Jun N-terminal kinase (JNK) in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Brain dialysis in conscious rats reveals an instantaneous massive release of striatal dopamine in response to MPP+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Parkinson's disease and exposure to agricultural work and pesticide chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Carrier-mediated processes in blood--brain barrier penetration and neural uptake of paraquat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

MPTP: insights into parkinsonian neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Acute mitochondrial and chronic toxicological effects of 1-methyl-4-phenylpyridinium in human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Cytotoxic and genotoxic potential of dopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Parkinson disease in twins: an etiologic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Effects of paraquat on mitochondrial electron transport system and catecholamine contents in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

Redox state of glutathione and thioredoxin in differentiation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFL125

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFL125

1 reference

18 September 2017

1 reference