(Q37970025)

26 August 2017

title

Mitochondria at the interface between danger signaling and metabolism: role of unfolded protein responses in chronic inflammation (English)

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26 August 2017

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26 August 2017

Eva Rath

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26 August 2017

publication date

19 December 2011

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Inflammatory Bowel Diseases

26 August 2017

published in

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26 August 2017

volume

18

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26 August 2017

issue

7

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26 August 2017

page(s)

1364-1377

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The role of the unfolded protein response in tumour development: friend or foe?

26 August 2017

cites work

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From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

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Coordination of metabolic plasticity in skeletal muscle

21 January 2018

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ER stress response, peroxisome proliferation, mitochondrial unfolded protein response and Golgi stress response.

21 January 2018

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Molecular chaperones and protein quality control

21 January 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

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Mitochondrial-nuclear communications

21 January 2018

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Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

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Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

21 January 2018

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A mitochondrial specific stress response in mammalian cells

21 January 2018

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ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

21 January 2018

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Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

21 January 2018

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The chop gene contains an element for the positive regulation of the mitochondrial unfolded protein response

21 January 2018

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Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements

21 January 2018

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Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.

21 January 2018

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Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

21 January 2018

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Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

21 January 2018

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Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions

21 January 2018

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ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

21 January 2018

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Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: a molecular mechanism leading to hepatic insulin resistance

21 January 2018

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XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

21 January 2018

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Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients

21 January 2018

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A role for mitochondria in NLRP3 inflammasome activation

21 January 2018

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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

1 reference

21 January 2018

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

21 January 2018

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

21 January 2018

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XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

21 January 2018

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

21 January 2018

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

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Perk is essential for translational regulation and cell survival during the unfolded protein response

21 January 2018

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Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species

21 January 2018

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Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

21 January 2018

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

21 January 2018

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

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Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response

21 January 2018

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ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum

21 January 2018

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Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

21 January 2018

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Mediators of endoplasmic reticulum stress-induced apoptosis

21 January 2018

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New mitochondrial carriers: an overview.

21 January 2018

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The internal structure of mitochondria

21 January 2018

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Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller

21 January 2018

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Redox pathways of the mitochondrion

21 January 2018

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Import and assembly of proteins into mitochondria of mammalian cells

21 January 2018

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Hsp70 proteins in protein translocation

21 January 2018

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The protein import machinery of mitochondria

21 January 2018

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Molecular chaperones as essential mediators of mitochondrial biogenesis

21 January 2018

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Complex I is the major site of mitochondrial superoxide production by paraquat

21 January 2018

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Mitochondrial stress signaling: a pathway unfolds.

21 January 2018

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Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

21 January 2018

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The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans

21 January 2018

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Role of the ABC transporter Mdl1 in peptide export from mitochondria

21 January 2018

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The mitochondrial UPR - protecting organelle protein homeostasis

21 January 2018

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Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

21 January 2018

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ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation

21 January 2018

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Mitochondrial biogenesis: which part of "NO" do we understand?

21 January 2018

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Mitochondrial signaling: the retrograde response

21 January 2018

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A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

21 January 2018

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Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle

21 January 2018

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Control of mitochondrial respiration by NO*, effects of low oxygen and respiratory state

21 January 2018

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AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

21 January 2018

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Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

21 January 2018

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Metabolic control through the PGC-1 family of transcription coactivators

21 January 2018

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

21 January 2018

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MIDAS/GPP34, a nuclear gene product, regulates total mitochondrial mass in response to mitochondrial dysfunction

21 January 2018

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Disruption of fusion results in mitochondrial heterogeneity and dysfunction

21 January 2018

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The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system

21 January 2018

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Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

21 January 2018

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Mitochondrial biogenesis in the axons of vertebrate peripheral neurons

21 January 2018

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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

21 January 2018

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

21 January 2018

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

21 January 2018

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Effect of IGF-1 on the balance between autophagy of dysfunctional mitochondria and apoptosis

21 January 2018

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21 January 2018

Mechanisms of mitophagy

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

21 January 2018

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Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM).

21 January 2018

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Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM).

21 January 2018

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The subcellular distribution of calnexin is mediated by PACS-2

21 January 2018

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MAM: more than just a housekeeper

21 January 2018

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Quantitating protein synthesis, degradation, and endogenous antigen processing

21 January 2018

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Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

21 January 2018

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The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria

21 January 2018

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Endoplasmic reticulum stress induces calcium-dependent permeability transition, mitochondrial outer membrane permeabilization and apoptosis

21 January 2018

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Role and regulation of the ER chaperone BiP.

21 January 2018

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Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

21 January 2018

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The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

21 January 2018

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Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response

21 January 2018

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ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum

21 January 2018

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PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

21 January 2018

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

21 January 2018

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Dysfunctional mitochondria contain endogenous high-affinity human Toll-like receptor 4 (TLR4) ligands and induce TLR4-mediated inflammatory reactions.

21 January 2018

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Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response

21 January 2018

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Reactive species-mediated regulation of cell signaling and the cell cycle: the role of MAPK.

21 January 2018

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Mitochondrial ROS fuel the inflammasome

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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Mitochondria: more than just a powerhouse

21 January 2018

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The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.

21 January 2018

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Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

21 January 2018

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Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

21 January 2018

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IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation

21 January 2018

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Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis

21 January 2018

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

21 January 2018

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Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis

21 January 2018

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Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation

21 January 2018

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Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation

21 January 2018

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Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis

21 January 2018

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

21 January 2018

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Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

21 January 2018

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Coupling endoplasmic reticulum stress to the cell death program

21 January 2018

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Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression

21 January 2018

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

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Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

21 January 2018

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

21 January 2018

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

21 January 2018

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

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Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

21 January 2018

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis

21 January 2018

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Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases

21 January 2018

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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

21 January 2018

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Reduced Paneth cell alpha-defensins in ileal Crohn's disease

21 January 2018

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Paneth cells and inflammation dance together in Crohn's disease

21 January 2018

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

21 January 2018

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Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria

21 January 2018

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Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization.

21 January 2018

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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

21 January 2018

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Uncoupling protein UCP2: when mitochondrial activity meets immunity.

21 January 2018

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Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

21 January 2018

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Autophagy regulates lipid metabolism

21 January 2018

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

21 January 2018

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Fatty acid oxidation disorders

21 January 2018

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Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice

21 January 2018

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Inflammatory bowel disease

21 January 2018

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Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation

21 January 2018

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Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon

21 January 2018

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Epithelia under metabolic stress perceive commensal bacteria as a threat

21 January 2018

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Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease

21 January 2018

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Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease

21 January 2018

1 reference

Evolving paradigms in the pathogenesis of IBD.

21 January 2018

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Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.

21 January 2018

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Expression of short-chain fatty acid receptor GPR41 in the human colon.

21 January 2018

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GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

21 January 2018

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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

21 January 2018

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Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IBD.21944

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26 August 2017

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