(Q37982939)

26 August 2017

Selection of regulatory T cells in the thymus (English)

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26 August 2017

Chyi-Song Hsieh

1

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26 August 2017

Hyang-Mi Lee

series ordinal

2

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26 August 2017

Chan-Wang J Lio

series ordinal

3

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26 August 2017

10 February 2012

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Nature Reviews Immunology

26 August 2017

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26 August 2017

12

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26 August 2017

3

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26 August 2017

157-167

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https://scigraph.springernature.com/pub.10.1038/nri3155

26 August 2017

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cites work

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

1 reference

Regulatory T cells and Foxp3

31 March 2020

1 reference

FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome

31 March 2020

1 reference

Foxp3 and natural regulatory T cells: key to a cell lineage?

31 March 2020

1 reference

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

31 March 2020

1 reference

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

31 March 2020

1 reference

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

31 March 2020

1 reference

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation

31 March 2020

1 reference

Developmental regulation of Foxp3 expression during ontogeny.

31 March 2020

1 reference

In vivo instruction of suppressor commitment in naive T cells

31 March 2020

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A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity

31 March 2020

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Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

31 March 2020

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Origin of regulatory T cells with known specificity for antigen

31 March 2020

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Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen

31 March 2020

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The timing of TCR alpha expression critically influences T cell development and selection

31 March 2020

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Regulatory T cells in the control of immune pathology.

31 March 2020

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Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells

31 March 2020

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Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells

31 March 2020

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Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

31 March 2020

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Massive thymic deletion results in systemic autoimmunity through elimination of CD4+ CD25+ T regulatory cells

31 March 2020

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Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

31 March 2020

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Early events in the thymus affect the balance of effector and regulatory T cells

31 March 2020

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Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells

31 March 2020

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TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

31 March 2020

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Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

31 March 2020

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Intraclonal competition limits the fate determination of regulatory T cells in the thymus

31 March 2020

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

31 March 2020

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CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg

31 March 2020

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A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease

31 March 2020

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An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

31 March 2020

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Becoming self-aware: the thymic education of regulatory T cells.

31 March 2020

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An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

31 March 2020

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An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

31 March 2020

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Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.

31 March 2020

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CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion

31 March 2020

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Graded deletion and virus-induced activation of autoreactive CD4+ T cells

31 March 2020

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Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

31 March 2020

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Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

31 March 2020

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Genetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes

31 March 2020

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Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

31 March 2020

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Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

31 March 2020

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

31 March 2020

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B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion

31 March 2020

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The impact of negative selection on thymocyte migration in the medulla.

31 March 2020

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

31 March 2020

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Antigen-specific peripheral shaping of the natural regulatory T cell population

31 March 2020

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Peripheral autoantigen induces regulatory T cells that prevent autoimmunity

31 March 2020

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Cutting edge: normal regional lymph node enrichment of antigen-specific regulatory T cells with autoimmune disease-suppressive capacity

31 March 2020

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Response to self antigen imprints regulatory memory in tissues

31 March 2020

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NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells

31 March 2020

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Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

31 March 2020

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The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

31 March 2020

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.

31 March 2020

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Foxo transcription factors control regulatory T cell development and function

31 March 2020

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Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

31 March 2020

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Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

31 March 2020

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Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome

31 March 2020

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

31 March 2020

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Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

31 March 2020

1 reference

Role of B7 in T cell tolerance

31 March 2020

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CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

31 March 2020

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CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.

31 March 2020

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CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

31 March 2020

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Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development

31 March 2020

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A two-step process for thymic regulatory T cell development.

31 March 2020

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

31 March 2020

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CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

31 March 2020

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IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

31 March 2020

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IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

31 March 2020

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Nonredundant roles for Stat5a/b in directly regulating Foxp3

31 March 2020

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Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.

31 March 2020

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Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice

31 March 2020

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Foxp3-dependent programme of regulatory T-cell differentiation

31 March 2020

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Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

31 March 2020

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

31 March 2020

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A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

31 March 2020

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Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development

31 March 2020

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Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes

31 March 2020

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Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells

31 March 2020

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Regulatory T cell lineage specification by the forkhead transcription factor foxp3

31 March 2020

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Differentiation of regulatory Foxp3+ T cells in the thymic cortex

31 March 2020

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Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

31 March 2020

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Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

31 March 2020

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Rare development of Foxp3+ thymocytes in the CD4+CD8+ subset

31 March 2020

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

31 March 2020

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Dendritic cells in the thymus contribute to T-regulatory cell induction

31 March 2020

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Antigen presentation in the thymus for positive selection and central tolerance induction

31 March 2020

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Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

31 March 2020

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31 March 2020

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Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

31 March 2020

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The thymic medulla: a unique microenvironment for intercellular self-antigen transfer

31 March 2020

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Autonomous versus dendritic cell-dependent contributions of medullary thymic epithelial cells to central tolerance

31 March 2020

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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

31 March 2020

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

31 March 2020

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Diversity of TCRs on natural Foxp3+ T cells in mice lacking Aire expression

31 March 2020

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Cell interactions in the induction of tolerance: the role of thymic lymphocytes

31 March 2020

1 reference

12 December 2020

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

1 reference

12 December 2020

Tissue-specific suppressor T cells involved in self-tolerance are activated extrathymically by self-antigens

1 reference

12 December 2020

Early events in the thymus affect the balance of effector and regulatory T cells.

1 reference

12 December 2020

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

1 reference

12 December 2020

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3155

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Dimensions Publication ID

26 August 2017

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