(Q37983497)

26 August 2017

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug (English)

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26 August 2017

Simone Cardaci

1

1 reference

PubMed ID

22328057

26 August 2017

Enrico Desideri

series ordinal

2

1 reference

PubMed ID

22328057

26 August 2017

Maria Rosa Ciriolo

series ordinal

3

1 reference

26 August 2017

1 February 2012

1 reference

Journal of Bioenergetics and Biomembranes

26 August 2017

1 reference

26 August 2017

44

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26 August 2017

1

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26 August 2017

17-29

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https://scigraph.springernature.com/pub.10.1007/s10863-012-9422-7

26 August 2017

0 references

cites work

P-glycoprotein: from genomics to mechanism.

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Glycolysis: a bioenergetic or a survival pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Novel roles for GAPDH in cell death and carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

The determination of osteopetrotic phenotypes by selective inactivation of red cell carbonic anhydrase isoenzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Somatostatin analogs for the treatment of neuroendocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targets of 3-bromopyruvate, a new, energy depleting, anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Glycolysis—one of the keys to cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Sugar-free approaches to cancer cell killing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate i

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Sodium-coupled monocarboxylate transporters in normal tissues and in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Second-generation tyrosine kinase inhibitors: the future of frontline CML therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

GAPDH mediates nitrosylation of nuclear proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Regulation of Na(+)-coupled glucose carrier SGLT1 by human papillomavirus 18 E6 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Pyruvate kinase type M2 and its role in tumor growth and spreading

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Changes in MCT 1, MCT 4, and LDH expression are tissue specific in rats after long-term hypobaric hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Interfering with pH regulation in tumours as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

ROS stress in cancer cells and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

2-deoxyglucose induces Noxa-dependent apoptosis in alveolar rhabdomyosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Kinetics of transport and phosphorylation of glucose in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Mechanisms underlying modulation of monocarboxylate transporter 1 (MCT1) by somatostatin in human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targeting multidrug resistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Targeting cancer metabolism: a therapeutic window opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10863-012-9422-7

Escherichia coli pyruvate dehydrogenase complex. Thiamin pyrophosphate-dependent inactivation by 3-bromopyruvate

21 January 2018

1 reference

12 December 2020

Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human pancreatic adenocarcinoma.

1 reference

12 December 2020

Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells

1 reference

12 December 2020

3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines

1 reference

12 December 2020

GLUT1 Messenger RNA and Protein Induction Relates to the Malignant Transformation of Cervical Cancer

1 reference

12 December 2020

Clinical Evidence Supporting the Role of Lonidamine for the Treatment of BPH.

1 reference

12 December 2020

Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs.

1 reference

12 December 2020

Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation

1 reference

12 December 2020

The inactivation of succinate dehydrogenase by bromopyruvate

1 reference

12 December 2020

Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production.

1 reference

12 December 2020

Transport of pyruvate in mitochondria from different tumor cells

1 reference

12 December 2020

Phloridzin and phloretin inhibition of 2-deoxy-D-glucose uptake by tumor cells in vitro and in vivo.

1 reference

12 December 2020

The monocarboxylate transporter family--role and regulation

1 reference

12 December 2020

Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases.

1 reference

12 December 2020

Effects of bromopyruvate on the control and catalytic properties of glutamate dehydrogenase

1 reference

12 December 2020

Phase III trial with and without lonidamine in non-small cell lung cancer

1 reference

12 December 2020

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Tumor response to ionizing radiation and combined 2-deoxy-D-glucose application in EATC tumor bearing mice: monitoring of tumor size and microscopic observations

1 reference

12 December 2020

Effect of 2-deoxy-D-glucose on various malignant cell lines in vitro.

1 reference

12 December 2020

LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES

1 reference

12 December 2020

Bromopyruvate inactivation of glutamate apodecarboxylase. Kinetics and specificity

1 reference

12 December 2020

Identification of the bromopyruvate-sensitive glutamate within the active site of 2-keto-3-deoxygluconate-6-P aldolase

1 reference

12 December 2020

The substrate analog bromopyruvate as a substrate, an inhibitor and an alkylating agent of malic enzyme of pigeon liver

1 reference

12 December 2020

Intracellular accumulation of ascorbic acid is inhibited by flavonoids via blocking of dehydroascorbic acid and ascorbic acid uptakes in HL-60, U937 and Jurkat cells

1 reference

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death

1 reference

12 December 2020

Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.

1 reference

12 December 2020

Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP.

1 reference

12 December 2020

10.1007/S10863-012-9422-7

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22328057