(Q37984231)

26 August 2017

Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes (English)

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26 August 2017

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Ellen K Grishman

1

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26 August 2017

Perrin C White

series ordinal

2

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26 August 2017

Rashmin C Savani

series ordinal

3

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26 August 2017

language of work or name

English

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publication date

15 February 2012

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26 August 2017

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26 August 2017

71

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26 August 2017

626-632

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26 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/pr.2012.24

26 August 2017

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cites work

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes

21 January 2018

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beta-Cell death during progression to diabetes

21 January 2018

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Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity

21 January 2018

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NALP inflammasomes: a central role in innate immunity.

21 January 2018

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Murine macrophages and pancreatic beta cells. Chemotactic properties of insulin and beta-cytostatic action of interleukin 1.

21 January 2018

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Gene Expression in Peripheral Blood Mononuclear Cells from Children with Diabetes

21 January 2018

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Increased TLR2 expression in patients with type 1 diabetes: evidenced risk of microalbuminuria.

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Serum IL-1beta, IL-2, and IL-6 in insulin-dependent diabetic children

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

High glucose induces toll-like receptor expression in human monocytes: mechanism of activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics.

21 January 2018

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Sustained IL-1alpha, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end products

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

21 January 2018

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Gene expression profiling of human pancreatic islets undergoing a simulated process of instant blood-mediated inflammatory reaction

21 January 2018

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Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Role of MKK3 and p38 MAPK in cytokine-induced death of insulin-producing cells

21 January 2018

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The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Pancreatic beta-cell damage mediated by beta-cell production of interleukin-1. A novel mechanism for virus-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Antidiabetic effects of interleukin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

TLRs and chronic inflammation.

21 January 2018

1 reference

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Drugs targeting Toll-like receptors

21 January 2018

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Toll-like receptor expression on peripheral blood mononuclear cells in asthmatics; implications for asthma management

21 January 2018

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The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease

21 January 2018

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The role of toll-like receptors in rheumatoid arthritis

21 January 2018

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Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state

21 January 2018

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Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes.

21 January 2018

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The diacylated lipopeptide FSL-1 induces TLR2-mediated Th2 responses.

21 January 2018

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https://api.crossref.org/works/10.1038%2FPR.2012.24

Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Involvement of the TLR4 (Toll-like receptor4) signaling pathway in palmitate-induced INS-1 beta cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Circulating lipids and glycaemic control in insulin dependent diabetic children

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

The NLRP3 inflammasome: a sensor for metabolic danger?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

IL-1beta processing in host defense: beyond the inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Is caspase 1 central to activation of interleukin-1?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Caspase-1 is not required for type 1 diabetes in the NOD mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Pioglitazone inhibits Toll-like receptor expression and activity in human monocytes and db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

The pathogenesis of insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Altered Toll-like receptor signaling pathways in human type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Interleukin-1 reduces the glycolytic utilization of glucose by pancreatic islets and reduces glucokinase mRNA content and protein synthesis by a nitric oxide-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Protection from experimental autoimmune diabetes in the non-obese diabetic mouse with soluble interleukin-1 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

Preliminary studies related to anti-interleukin-1β therapy in children with newly diagnosed type 1 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FPR.2012.24

31 March 2020

Identifiers

DOI

10.1038/PR.2012.24

1 reference

26 August 2017

1 reference