(Q37992508)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22407107%20AND%20SRC:MED&resulttype=core&format=json

25 January 2020

title

Role of monocarboxylate transporters in human cancers: state of the art (English)

1 reference

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25 January 2020

5

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25 January 2020

Adhemar Longatto-Filho

2

1 reference

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25 January 2020

João Azevedo-Silva

3

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25 January 2020

Margarida Casal

4

1 reference

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25 January 2020

Fernando Schmitt

6

1 reference

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25 January 2020

Fatima Baltazar

7

1 reference

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25 January 2020

author name string

Céline Pinheiro

1

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25 January 2020

publication date

1 February 2012

1 reference

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Journal of Bioenergetics and Biomembranes

25 January 2020

published in

1 reference

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25 January 2020

volume

44

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25 January 2020

issue

1

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25 January 2020

page(s)

127-139

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https://scigraph.springernature.com/pub.10.1007/s10863-012-9428-1

25 January 2020

exact match

0 references

cites work

Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance

1 reference

12 December 2020

The precrystalline cytoplasmic granules of alveolar soft part sarcoma contain monocarboxylate transporter 1 and CD147.

1 reference

12 December 2020

On the Origin of Cancer Cells

1 reference

12 December 2020

Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study

1 reference

12 December 2020

Inhibitory effects of statins on human monocarboxylate transporter 4.

1 reference

12 December 2020

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma

1 reference

12 December 2020

Hypoxia-inducible expression of tumor-associated carbonic anhydrases

1 reference

12 December 2020

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

1 reference

12 December 2020

Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

1 reference

12 December 2020

Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH.

1 reference

12 December 2020

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

1 reference

12 December 2020

CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

1 reference

12 December 2020

Why do cancers have high aerobic glycolysis?

1 reference

12 December 2020

Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

1 reference

12 December 2020

Endothelial cell response to lactate: implication of PAR modification of VEGF.

1 reference

12 December 2020

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

1 reference

12 December 2020

Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification.

1 reference

12 December 2020

Cellular and subcellular expression of monocarboxylate transporters in the pigment epithelium and retina of the rat

1 reference

12 December 2020

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 December 2020

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

1 reference

12 December 2020

Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression

1 reference

12 December 2020

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

1 reference

12 December 2020

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10

1 reference

12 December 2020

The prognostic value of CD147/EMMPRIN is associated with monocarboxylate transporter 1 co-expression in gastric cancer.

1 reference

12 December 2020

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review

1 reference

12 December 2020

Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle.

1 reference

12 December 2020

Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.

1 reference

12 December 2020

Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes

1 reference

12 December 2020

Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44

1 reference

12 December 2020

Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma.

1 reference

12 December 2020

Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis?

1 reference

12 December 2020

miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1.

1 reference

12 December 2020

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis

1 reference

12 December 2020

Identification of a monocarboxylate transporter isoform type 1 (MCT1) on the luminal membrane of human and pig colon

1 reference

12 December 2020

Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231.

1 reference

12 December 2020

Monocarboxylate transporters 1 and 4 are associated with CD147 in cervical carcinoma.

1 reference

12 December 2020

Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids

1 reference

12 December 2020

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.

1 reference

12 December 2020

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

1 reference

12 December 2020

Hypoxic Regulation of Lactate Dehydrogenase A

1 reference

12 December 2020

Metabolic changes during carcinogenesis: potential impact on invasiveness.

1 reference

12 December 2020

Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression

1 reference

12 December 2020

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

1 reference

12 December 2020

Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells

1 reference

12 December 2020

Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: role of pyruvate kinase type M2 and the glycolytic-enzyme complex

1 reference

12 December 2020

Mechanism of action of the antineoplastic drug lonidamine: 31P and 13C nuclear magnetic resonance studies

1 reference

12 December 2020

Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited

1 reference

12 December 2020

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

1 reference

12 December 2020

Increasing expression of monocarboxylate transporters 1 and 4 along progression to invasive cervical carcinoma.

1 reference

12 December 2020

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

12 December 2020

Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism

1 reference

12 December 2020

Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE

1 reference

12 December 2020

Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation

1 reference

12 December 2020

Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function.

1 reference

12 December 2020

The Transporter Classification Database: recent advances

1 reference

12 December 2020

Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy

1 reference

12 December 2020

Aerobic glycolysis during lymphocyte proliferation

1 reference

12 December 2020

Lactate-proton cotransport in skeletal muscle

1 reference

12 December 2020

Regulation of intracellular pH in human melanoma: potential therapeutic implications.

1 reference

12 December 2020

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

1 reference

12 December 2020

Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1

1 reference

12 December 2020

Reduced expression of GNA11 and silencing of MCT1 in human breast cancers

1 reference

12 December 2020

The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma

1 reference

12 December 2020

Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study

1 reference

12 December 2020

CD44 in cancer progression: adhesion, migration and growth regulation

1 reference

12 December 2020

Regulation of T lymphocyte metabolism

1 reference

12 December 2020

Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies

1 reference

12 December 2020

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

1 reference

12 December 2020

Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1).

1 reference

12 December 2020

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

1 reference

12 December 2020

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

12 December 2020

Metabolic mapping with bioluminescence: basic and clinical relevance

1 reference

12 December 2020

Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse

1 reference

12 December 2020

Energy metabolism in tumor cells

1 reference

12 December 2020

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

1 reference

12 December 2020

Osteoblast expression of vascular endothelial growth factor is modulated by the extracellular microenvironment

1 reference

12 December 2020

Metabolic targeting of lactate efflux by malignant glioma inhibits invasiveness and induces necrosis: an in vivo study

1 reference

12 December 2020

Roles of the multifunctional glycoprotein, emmprin (basigin; CD147), in tumour progression

1 reference

12 December 2020

Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression.

1 reference

12 December 2020

Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism

1 reference

12 December 2020

Oncogenic alterations of metabolism

1 reference

12 December 2020

Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces cerevisiae.

1 reference

12 December 2020

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

1 reference

12 December 2020

Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells

1 reference

12 December 2020

Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes

1 reference

12 December 2020

Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7.

1 reference

12 December 2020

Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Correlation of high lactate levels in human cervical cancer with incidence of metastasis

1 reference

12 December 2020

cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

1 reference

12 December 2020

Mechanisms regulating tissue-specific polarity of monocarboxylate transporters and their chaperone CD147 in kidney and retinal epithelia

1 reference

12 December 2020

Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms

1 reference

12 December 2020

Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast

1 reference

12 December 2020

Specific inhibition of pyruvate transport in rat liver mitochondria and human erythrocytes by alpha-cyano-4-hydroxycinnamate

1 reference

12 December 2020

CD147 immunoglobulin superfamily receptor function and role in pathology

1 reference

12 December 2020

Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

1 reference

12 December 2020

Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease

1 reference

12 December 2020

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.

1 reference

12 December 2020

Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1

1 reference

12 December 2020

The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

1 reference

12 December 2020

Hypoxia, clonal selection, and the role of HIF-1 in tumor progression

1 reference

12 December 2020

A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysis

1 reference

12 December 2020

Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration

1 reference

12 December 2020

Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells

1 reference

12 December 2020

Lung cancer: a comparative study of metabolism related protein expression in cancer cells and tumor associated stroma

1 reference

12 December 2020

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

12 December 2020

Tumor microenvironment modulates hyaluronan expression: the lactate effect.

1 reference

12 December 2020

Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

1 reference

12 December 2020

18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterization

1 reference

12 December 2020

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

1 reference

12 December 2020

Hyaluronan: a constitutive regulator of chemoresistance and malignancy in cancer cells

1 reference

12 December 2020

Substrate and inhibitor specificity of monocarboxylate transport into heart cells and erythrocytes. Further evidence for the existence of two distinct carriers

1 reference

12 December 2020

Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.

1 reference

12 December 2020

High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers

1 reference

12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

12 December 2020

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

1 reference

12 December 2020

Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

1 reference

12 December 2020