(Q37999093)

26 August 2017

The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery (English)

1 reference

26 August 2017

1 reference

Craig E Thomas

1

1 reference

PubMed ID

22468913

26 August 2017

Yvonne Will

series ordinal

2

1 reference

PubMed ID

22468913

26 August 2017

language of work or name

English

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publication date

9 January 2012

1 reference

Expert Opinion on Drug Discovery

26 August 2017

1 reference

26 August 2017

7

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26 August 2017

2

1 reference

26 August 2017

109-122

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Navigating chemical space for biology and medicine

26 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Computer systems for the prediction of toxicity: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Use of the Miniscreen assay to screen novel compounds for bacterial mutagenicity in the pharmaceutical industry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

In vivo mutation assay based on the endogenous Pig-a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

New and emerging technologies for genetic toxicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Micro-electrode arrays in cardiac safety pharmacology: a novel tool to study QT interval prolongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Identification of a specific radioligand for the cardiac rapidly activating delayed rectifier K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

In silico risk assessment for drug-induction of cardiac arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Application of genomics in preclinical drug safety evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

The evolution of bioinformatics in toxicology: advancing toxicogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Current and future applications of toxicogenomics: Results summary of a survey from the HESI Genomics State of Science Subcommittee

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Development of an in vitro liver toxicity prediction model based on longer term primary rat hepatocyte culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Temporal gene expression analysis of monolayer cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Drug-induced phospholipidosis: issues and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Quantitative knowledge-based analysis in compound safety assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Pathway analysis tools and toxicogenomics reference databases for risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Predictive Power Estimation Algorithm (PPEA)--a new algorithm to reduce overfitting for genomic biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Cellular imaging predictions of clinical drug-induced liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Respirometric Screening Technology for ADME-Tox studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Three-dimensional cellular microarray for high-throughput toxicology assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Human pluripotent stem cells in drug discovery and predictive toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Present state and future perspectives of using pluripotent stem cells in toxicology research

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

The embryonic stem cell test combined with toxicogenomics as an alternative testing model for the assessment of developmental toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Evaluation of novel high-throughput embryonic stem cell tests with new molecular markers for screening embryotoxic chemicals in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Stem cells in toxicology: fundamental biology and practical considerations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Zebrafish-Based Small Molecule Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

Development and application of bioluminescent Caenorhabditis elegans as multicellular eukaryotic biosensors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.651122

10.1517/17460441.2012.651122

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22468913